First a question, are you doing Calcipot/5-FU (Calcipotriene/Fluorouracil) or just straight Fluorouracil?
This summer I did the blended version of the two. Mine was a 7 day application and by day 3 I was blistered like I had laid out in the sun for days. By day 7 the bad spots on my face were weeping and bleeding.
By day 14 with no applications for 7 days I was really blistered, weeping, bleeding and pealing but it was starting to ease up on the pain. By day 21 I was still a little bit red, but I had nice smooth skin.
The dermatologist was very satisfied with the results.
Best of luck on this treatment. I will be judiciously applying sun screen before daylight when on the lake and have purchased a few new sun hats.

I have used it on my entire face. Not a good experience but did its job. At least my Dr. is happy. Try using Aquaphor if your Dr says it is OK. Sure relives the pain.

I use it twice a year - cover my face, neck, ears, etc over two weeks - I have only had Keratosis spots which are pre skin cancer - see my doctor every 6 months to make sure I have not missed anything

Guys, it doesn’t have to be this way. The sun is not bad for you. It doesn’t even make sense that it would be. I know I’m not a reliable source. I’m a nobody. But you’ve been lied to your entire life. We all have. I’m not the expert, but I do listen to those that are. It’s your diet that causes this stuff. Avoiding the sun and covering yourself in chemicals is not the answer. Take a minute and think about it. Are a bunch of manmade chemicals better for you than what nature provides? Does it make any sense that the sun is giving you cancer? It’s our best form of vitamin d, which is not only essential, but one of our most important vitamins. It does not add up. You’ve been told that the sun causes cancer by the same people that tell you that Lucky Charms is healthier than beef, and that the Covid “vaccine” is not only necessary but safe. Fats are bad and grains are good. It’s all backwards. It’s all a lie. The information is out there. Stop listening to the main stream narrative and do your own research. It’s a lot like politics. Listen to the usual suspects and you’d be voting for democrats. Health information is no different. The “experts” that push the modern day diet have been paid off. It’s a scam. Your typical physician is not versed in these things. They regurgitate what they’ve been taught in school. How reliable are our schools?

Sorry for going off on a tangent. I just hate to see decent people going down the wrong path. I’ve seen proper diets change people’s lives in unbelievable ways. The real life evidence is out there. It’s not hard to find, either. The sun is not killing you. Your diet is.

I have no incentive to push this. I’m not selling anything. I just hate to see people believing lies that are detrimental to their health. I realize many will criticize me since I’m not a physician and their doctor told them otherwise. That’s fine. Believe what you want. I’m just telling you that there is a better way, and the evidence speaks for itself. If you’re interested, you can contact me, or you can look it up for yourself. If not, whatever. It’s your life.

I've had to use it twice on my face and neck. Get the softest wash cloth you can find to make cleaning it not feel like sand paper. It will eventually feel like putting acid on your face.
It did what it was supposed to do though. I used Aquaphor as well.

I would hope the first time is the worst and the follow up times not as bad?