While some are surprised at your question, I'm glad you asked. Guessing is never a good way to find an answer.

When it comes to dangerous things, the only stupid question is one that isn't asked.

In a rifled barrel, the distance is measured between opposing lands or grooves; groove measurements are common in cartridge designations originating in the United States, while land measurements are more common elsewhere. It is important to performance that a bullet should closely match the groove diameter of a barrel to ensure a good seal. When the barrel diameter is given in inches, the abbreviation "cal" is used in place of "inches." For example, a small bore rifle with a diameter of 0.22 inch is a .22 cal; however, the decimal point is generally dropped when spoken, making it "twenty-two caliber" or a "two-two caliber". Calibers of firearms can be referred to in millimeters, as in a "caliber of eighty-eight millimeters" (88 mm) or "a hundred and five-millimeter caliber gun" (often abbreviated as "105 mm gun").

While modern cartridges and cartridge firearms are generally referred to by the cartridge name, they are still lumped together based on bore diameter. For example, a firearm might be described as a ".30 caliber rifle", which could be any of a wide range of cartridges using a roughly .30 inch projectile; or a ".22 rimfire", referring to any rimfire cartridge using a .22 caliber projectile.
more
http://en.wikipedia.org/wiki/Caliber