Do not underestimate the 22lr with proper shot placement.
.
I’ve killed a nilgai cow and a full grown black angus cow with a .22…..no I wasn’t out to prove anything, it’s just what I had in my hand at the time, in a literal sense.
What’s weird, is both of those went down with one shot and then got a (probably unnecessary) follow up shot once I got to them. Both taken at about 40 yards.
But I can’t kill a coon or feral cat with 1 shot to save my life.