Don't think the agriculture lobby is going to stand for a ban of Ag products. And the thought of testing 100% of killed deer is a pain in the butt I think most of us hope never comes to pass. Again, going to extremes to try to prove a point doesn't.

No one is trying to change your position that I can see on this thread. Why are you avoiding answering therancher's question? How do you propose we resist and slow CWD's progress?

And I'm curious, what is your profession?

As I said, Texas CWD is likely inevitable, but I think efforts being made to slow its advance via testing, and containment strategy are reasonable.

I think it likely that so much research is going into CWD because it is a relatively young disease, with unknown potentials, and considering that at least one form of spongiform encephalopathy has jumped to humans there is concern about one that exists in a difficult to control wild population. As to EHD, and anthrax, they are both terrible diseases, but they involve a much different mechanism, incubation is relatively short, and mortality follows shortly, often limiting the outbreak locally. Also I'm pretty sure anthrax is pretty high up there in diseases that have had research money considering how long it's been considered a potential weapon.

I don't know that anyone on this thread has said that CWD should be a bigger concern than EHD or anthrax anyway, just that it's not something to be taken likely.

So you think it's reasonable to kill healthy deer by the thousands?

Bobo didn't take my position to an extreme conclusion right there in the material you quoted? That because I thought a different approach for Texas than one used in an area where CWD is endemic might be appropriate means that I'm for erradication? That's a pretty steep change to me.

I wasn't avoiding therancher's questions, I just type slow on my phone, and heck, they hadn't even been up very long, see below for a response.

What does my profession have to do with anything?

That's impossible for me to answer without you answer to my question, isn't it?

We kill healthy deer by the hundreds of thousands every season, so yeah, seems pretty reasonable to me. You don't agree?

I wouldn't have a clue what's possible and what's not for you bud. But if it makes you feel better I run a small service based business, and I run a few cows on the side.

No I do not. Killing healthy deer to dump is not hunting as you know very well.

Common sense would tell me that a more effective approach would be test deer until they test positive. Separate the deer that test positive or show signs of being infected. Test and monitor these deer and learn all you can from them until they are deceased.

What type of small business service do you run?

I didn't know anyone was killing deer to dump, that doesn't seem reasonable at all, who is doing such a thing and why? You do know that there is presently no effective test to detect CWD in living deer, right? So separating infected deer until they show clinical symptoms isn't really doable. And since the deer must be dead to detect the disease observation after detection is of limited value.

Did you not just read in theranchers post that 50 healthy deer were killed on his friends deer farm? What do you think happens to all those deer? You can't sell them.

Ok so we separate the ones that show signs of being infected. And keep working on a live test until we have one. Would you not agree that the best way to do that is trying it on deer that show signs of being infected with the disease?


Please help me understand how killing healthy looking deer to test for this disease helps solve this problem?

I read it, did you not read my post where I pointed out that it was a hard number to place without context? I think what happens to all those deer is that they are tested for CWD, and if it's all clear he's allowed to release the rest as he pleases. I don't know enough about the current state of the deer business to know if other options such as selling them are available to him, but apparently that is the requirement for releasing them. As I said earlier, this is not without precedent, how many of the 4.5 million cows that were killed because of BSE actually had it? I bet a pretty low percentage. Is it an overreaction? Could be...but until an in vivo test is developed I guess this coal mine needs a canary. It's not just farmed deer that are being tested, roadkill is tested year round, heard a 3rd hand anecdote of sample collection last week.

No question it sucks for the deer farmers, and I hope there is soon a better answer, perhaps they will help develop one.

Live testing is being done every day and is considered as accurate as post mortem tests.

And you didn't know thousands of Texas deer are being killed annually and dumped. There's a lot you're behind on.

Also, there's comparatively no money being spent to understand or combat either EHD or anthrax. The insane protocol tpwd has adopted for CWD is bankrupting them.

Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

Location: Virus and Prion Research

Title: Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsies from white-tailed deer by real time quaking-induced conversion)

Author
item Haley, Nicholas
item Siepker, Chris
item Walter, W. David
item Thomsen, Bruce
item Greenlee, Justin
item Lehmkuhl, Aaron
item Richt, Jürgen

Submitted to: Journal of Clinical Microbiology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/27/2015
Publication Date: 2/10/2016

Citation: Haley, N.J., Siepker, C., Walter, W.D., Thomsen, B.V., Greenlee, J.J., Lehmkuhl, A.D., Richt, J.A. 2016. Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsy specimens from white-tailed deer by real time quaking-induced conversion. Journal of Clinical Microbiology. 54(4):1108-1116.

Interpretive Summary: Chronic Wasting Disease (CWD), a fatal neurodegenerative disease that occurs in farmed and wild cervids (deer and elk) of North America, is a transmissible spongiform encephalopathy (TSE). TSEs are caused by infectious proteins called prions that are resistant to various methods of decontamination and environmental degradation. Early diagnosis of CWD in wild and captive herds would be very helpful to controlling the spread of CWD, for which there are not yet any preventative or treatment measures available. The purpose of this study was to test a laboratory method of prion detection (real-time Quaking Induced Conversion; RT-QuIC) that has the potential to detect very low levels of infectious prions in samples collected from live animals against the gold standard diagnostic where abnormal prion in tissues is stained on a microscope slide. This study reports that RT-QuIC detects more cases of CWD than standard methods, but also can identify a small number of animals without CWD as being positive. In the case of CWD, where it is likely that large numbers of animals within a herd may be positive, misidentifying a negative as a positive may have less of an impact than in the case of other prion diseases such as bovine spongiform encephalopathy considering that this test allows testing much larger numbers of samples with a faster turn around time than traditional methods. This information could have an impact on regulatory and wildlife officials developing plans to reduce or eliminate CWD and cervid farmers that want to ensure that their herd remains CWD-free.

Technical Abstract: Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, was first documented nearly fifty years ago in Colorado and Wyoming and has since spread to cervids in 23 states, 2 Canadian provinces, and the Republic of Korea. The increasing expansion of this disease makes the development of sensitive diagnostic assays and antemortem sampling techniques crucial for the mitigation of spread; this is especially true in cases of relocation/reintroduction of farmed or free-ranging deer and elk, or surveillance studies in private or protected herds where depopulation may be contraindicated. This study sought to evaluate the sensitivity of the real-time quaking-induced conversion (RT-QuIC) assay in samples collected antemortem. Antemortem findings were then compared to results from ante- and postmortem samples evaluated using the current gold standard diagnostic assay, immunohistochemistry (IHC). Recto-anal mucosal associated lymphoid tissue (RAMALT) biopsies and nasal brush collections from three separate herds of farmed white-tailed deer (n=409) were evaluated, along with standard postmortem microscopic analysis of brainstem at the level of the obex and retropharyngeal lymph nodes. We hypothesized the sensitivity of RT-QuIC would be comparable to IHC in antemortem tissues, and would correlate with both genotype and stage of clinical disease. Our results showed that RAMALT testing by RT-QuIC had the highest sensitivity (69.8%) when compared to postmortem testing. This data suggests that RT-QuIC, like IHC, is a fairly sensitive assay for detection of CWD prions in rectal biopsies and other antemortem samples, and with further investigation has potential for large scale and rapid automated testing for CWD diagnosis.

https://www.ars.usda.gov/research/publications/publication/?seqNo115=320291

http://chronic-wasting-disease.blogspot.com/2016/11/important-sawcorp-cwd-test-is-not-aphis.html

validity is key word. you don’t want a cwd test that works some of the time...there is already too much of the ‘OBEX ONLY’ testing syndrome going around $$$

From: Terry S. Singeltary Sr.

Sent: Sunday, February 14, 2016 12:42 PM

To: BSE-L@LISTS.AEGEE.ORG

Subject: [BSE-L] Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsies from white-tailed deer by real time quaking-induced conversion

Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsies from white-tailed deer by real time quaking-induced conversion

Nicholas J. Haleya#, Chris Siepkera, W. David Walterb, Bruce V. Thomsenc, Justin J. Greenleed, Aaron D. Lehmkuhlc and Jürgen A. Richta

+ Author Affiliations Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USAa U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, Pennsylvania State University, University Park, Pennsylvania, USAb 3USDA, APHIS, VS, STAS, National Veterinary Service Laboratories, Ames, Iowa, USAc Virus and Prion Research Unit, National Animal Disease Center, ARS, USDA, Ames, Iowa, USAd

ABSTRACT

Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, was first documented nearly fifty years ago in Colorado and Wyoming, and has since spread to cervids in 23 states, two Canadian provinces, and the Republic of Korea. The expansion of this disease makes the development of sensitive diagnostic assays and antemortem sampling techniques crucial for the mitigation of spread; this is especially true in cases of relocation/reintroduction of farmed or free-ranging deer and elk, or surveillance studies in private or protected herds where depopulation is contraindicated. This study sought to evaluate the sensitivity of the real-time quaking-induced conversion (RT-QuIC) assay using recto-anal mucosa associated lymphoid tissue (RAMALT) biopsies and nasal brush samples collected antemortem from farmed white-tailed deer (n=409). Antemortem findings were then compared to results from ante- and postmortem samples (RAMALT, brainstem and medial retropharyngeal lymph nodes) evaluated using the current gold standard in vitro assay, immunohistochemistry (IHC). We hypothesized the sensitivity of RT-QuIC would be comparable to IHC in antemortem tissues, and would correlate with both genotype and stage of clinical disease. Our results showed that RAMALT testing by RT-QuIC had the highest sensitivity (69.8%) when compared to postmortem testing, with a specificity of >93.9%. These data suggest that RT-QuIC, like IHC, is an effective assay for detection of PrPCWD in rectal biopsies and other antemortem samples, and with further research to identify more sensitive tissues, bodily fluids, or experimental conditions, has potential for large scale and rapid automated testing for CWD diagnosis.

FOOTNOTES

↵‪#‎Address‬ correspondence to Nicholas J. Haley, nicholas.j.haley@gmail.com. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

http://jcm.asm.org/content/early/2016/02...53-215bf8f74004

Saturday, February 20, 2016

Seeded amplification of chronic wasting disease prions in nasal brushings and recto-anal mucosa associated lymphoid tissues from elk by real time quaking-induced conversion

http://chronic-wasting-disease.blogspot.com/2016/02/seeded-amplification-of-chronic-wasting.html

Friday, August 28, 2015

*** Chronic Wasting Disease CWD TSE Prion Diagnostics and subclinical infection

http://chronic-wasting-disease.blogspot.com/2015/08/chronic-wasting-disease-cwd-tse-prion.html

Tuesday, September 22, 2015

*** Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype

http://transmissiblespongiformencephalop...ion-strain.html

FRIDAY, NOVEMBER 18, 2016

IMPORTANT: SAWCorp CWD Test is NOT APHIS Approved

http://chronic-wasting-disease.blogspot.com/2016/11/important-sawcorp-cwd-test-is-not-aphis.html

http://chronic-wasting-disease.blogspot.com/2016/02/parks-and-wildlife-begins-reducing-deer.html

a review since the TEXAS 84th Legislature commencing this January, deer breeders are expected to advocate for bills that will seek to further deregulate their industry...

http://www.chron.com/opinion/outlook/article/Sanders-Animal-husbandry-practices-threaten-5955166.php

Sunday, December 14, 2014

TEXAS 84th Legislature commencing this January, deer breeders are expected to advocate for bills that will seek to further deregulate their industry

http://chronic-wasting-disease.blogspot.com/2014/12/texas-84th-legislature-commencing-this.html

Tuesday, December 16, 2014

Texas 84th Legislature 2015 H.R. No. 2597 Kuempel Deer Breeding Industry TAHC TPWD CWD TSE PRION

http://chronic-wasting-disease.blogspot.com/2014/12/texas-84th-legislature-2015-hr-no-2597.html

Under Texas law, though, breeder deer belong to the state, not the permittee. See, e.g., TEX. PARKS & WILD. CODE §§ 1.011 (“All wild animals . . . inside the borders of this state are the property of the people of this state.”); 43.364 (“All breeder deer . . . are under the full force of the laws of [Texas] pertaining to deer . . . .”). While a permittee may have possession of the breeder deer, the deer are only “held under a permit[.]” Id. § 43.351. Nowhere do the statutes or regulations state that breeder deer become the property of a permit holder.4 Regardless, even if they did give ownership of breeder deer to permit holders, the Andertons were not permit holders when the deer were killed.

http://www.ca5.uscourts.gov/opinions%5Cunpub%5C14/14-10297.0.pdf

While a permittee may have possession of the breeder deer, the deer are only “held under a permit[.]” Id. § 43.351

http://www.statutes.legis.state.tx.us/Docs/PW/htm/PW.43.htm

S.B. No. 820

http://www.legis.state.tx.us/tlodocs/83R/billtext/html/SB00820F.HTM

http://openstates.org/tx/bills/83/SB820/

Texas Senate Bill

Relating to the management, breeding, and destruction of deer and to procedures regarding certain deer permits.

View latest bill text Session:83rd Legislature (2013)

http://openstates.org/tx/bills/83/SB820/

http://chronic-wasting-disease.blogspot.com/2015/08/tahc-chronic-wasting-disease-cwd-tse.html

http://chronic-wasting-disease.blogspot.com/2016/02/parks-and-wildlife-begins-reducing-deer.html

http://tpwd.texas.gov/huntwild/wild/diseases/cwd/tracking/#texasCWD

http://tpwd.texas.gov/huntwild/wild/dise...16-17Season.pdf

<<<***>>>The first known case of a captive-raised white-tailed deer in Texas that live tested “not detected” for CWD, but after being harvested by a hunter on a release site three months later tested positive for the disease.<<<

yep, did not take a rocket scientist to see this coming. how many more?

WEDNESDAY, JULY 22, 2015

Texas Certified Chronic Wasting Disease CWD Sample Collector, like the Wolf Guarding the Henhouse Just got off the phone with TAHC, and I wanted to confirm this. but it seems true, that in the state of Texas, even if you are a Captive game farmer, breeder, part of the captive industry at all, if you want to sample your own cervid for cwd, instead of the TAHC, TPWD, or Doctor, all you have to do is pass the Certified CWD Sample Collector course, and bingo, you sample your own herd. ...tss

http://chronic-wasting-disease.blogspot.com/2015/07/texas-certified-chronic-wasting-disease.htm

FRIDAY, JANUARY 27, 2017

TEXAS, Politicians, TAHC, TPWD, and the spread of CWD TSE Prion in Texas

http://chronic-wasting-disease.blogspot.com/2017/01/texas-politicians-tahc-tpwd-and-spread.html

FRIDAY, MARCH 31, 2017

TPWD UPDATE CWD TSE Prion 49 confirmed cases and unwanted firsts for Texas

http://chronic-wasting-disease.blogspot.com/2017/03/tpwd-update-cwd-tse-prion-49-confirmed.html

Terry S. Singeltary Sr.

i have terrible news folks...there goes the damn bacon too...terrible!

please don't shoot the messenger again...

Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease

Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

Location: Virus and Prion Research

Title: Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease

Author item Moore, Sarah item Kunkle, Robert item Kondru, Naveen item Manne, Sireesha item Smith, Jodi item Kanthasamy, Anumantha item West Greenlee, M item Greenlee, Justin

Submitted to: Prion Publication Type: Abstract Only Publication Acceptance Date: 3/15/2017 Publication Date: N/A Citation: N/A Interpretive Summary:

Technical Abstract: Aims: Chronic wasting disease (CWD) is a naturally-occurring, fatal neurodegenerative disease of cervids. We previously demonstrated that disease-associated prion protein (PrPSc) can be detected in the brain and retina from pigs challenged intracranially or orally with the CWD agent. In that study, neurological signs consistent with prion disease were observed only in one pig: an intracranially challenged pig that was euthanized at 64 months post-challenge. The purpose of this study was to use an antigen-capture immunoassay (EIA) and real-time quaking-induced conversion (QuIC) to determine whether PrPSc is present in lymphoid tissues from pigs challenged with the CWD agent. Methods: At two months of age, crossbred pigs were challenged by the intracranial route (n=20), oral route (n=19), or were left unchallenged (n=9). At approximately 6 months of age, the time at which commercial pigs reach market weight, half of the pigs in each group were culled (<6 month challenge groups). The remaining pigs (>6 month challenge groups) were allowed to incubate for up to 73 months post challenge (mpc). The retropharyngeal lymph node (RPLN) was screened for the presence of PrPSc by EIA and immunohistochemistry (IHC). The RPLN, palatine tonsil, and mesenteric lymph node (MLN) from 6-7 pigs per challenge group were also tested using EIA and QuIC. Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%).

Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains.

https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105 ;

CONFIDENTIAL

EXPERIMENTAL PORCINE SPONGIFORM ENCEPHALOPATHY

While this clearly is a cause for concern we should not jump to the conclusion that this means that pigs will necessarily be infected by bone and meat meal fed by the oral route as is the case with cattle. ...

http://web.archive.org/web/20031026000118/www.bseinquiry.gov.uk/files/yb/1990/08/23004001.pdf

we cannot rule out the possibility that unrecognised subclinical spongiform encephalopathy could be present in British pigs though there is no evidence for this: only with parenteral/implantable pharmaceuticals/devices is the theoretical risk to humans of sufficient concern to consider any action.

http://web.archive.org/web/20030822031154/www.bseinquiry.gov.uk/files/yb/1990/09/10007001.pdf

May I, at the outset, reiterate that we should avoid dissemination of papers relating to this experimental finding to prevent premature release of the information. ...

http://web.archive.org/web/20030822052332/www.bseinquiry.gov.uk/files/yb/1990/09/11005001.pdf

3. It is particularly important that this information is not passed outside the Department, until Ministers have decided how they wish it to be handled. ...

http://web.archive.org/web/20030822052438/www.bseinquiry.gov.uk/files/yb/1990/09/12002001.pdf

But it would be easier for us if pharmaceuticals/devices are not directly mentioned at all. ...

http://web.archive.org/web/20030518170213/www.bseinquiry.gov.uk/files/yb/1990/09/13004001.pdf

Our records show that while some use is made of porcine materials in medicinal products, the only products which would appear to be in a hypothetically ''higher risk'' area are the adrenocorticotrophic hormone for which the source material comes from outside the United Kingdom, namely America China Sweden France and Germany. The products are manufactured by Ferring and Armour. A further product, ''Zenoderm Corium implant'' manufactured by Ethicon, makes use of porcine skin - which is not considered to be a ''high risk'' tissue, but one of its uses is described in the data sheet as ''in dural replacement''. This product is sourced from the United Kingdom.....

http://web.archive.org/web/20030822054419/www.bseinquiry.gov.uk/files/yb/1990/09/21009001.pdf

snip...

It was not until . . . August 1990, that the result from the pig persuaded both SEAC and us to change our view and to take out of pig rations any residual infectivity that might have arisen from the SBOs.

http://web.archive.org/web/20071014143511/http://www.bseinquiry.gov.uk/files/tr/tab69.pdf

4.303 The minutes of the meeting record that:

It was very difficult to draw conclusions from one experimental result for what may happen in the field. However it would be prudent to exclude specified bovine offals from the pig diet. Although any relationship between BSE and the finding of a spongiform encephalopathy in cats had yet to be demonstrated, the fact that this had occurred suggested that a cautious view should be taken of those species which might be susceptible. The 'specified offals' of bovines should therefore be excluded from the feed of all species. 17

http://web.archive.org/web/20031026084516/http://www.bseinquiry.gov.uk/files/yb/1990/09/07001001.pdf

IN CONFIENCE

EXPERIMENTAL PORCINE SPONGIFORM ENCEPHALOPATHY

1. CMO should be aware that a pig inoculated experimentally (ic, iv, and ip) with BSE brain suspension has after 15 months developed an illness, now confirmed as a spongiform encephalopathy. This is the first ever description of such a disease in a pig, although it seems there ar no previous attempts at experimental inoculation with animal material. The Southwood group had thought igs would not be susceptible. Most pigs are slaughtered when a few weeks old but there have been no reports of relevant neurological illness in breeding sows or other elderly pigs. ...see full text ;

http://web.archive.org/web/20040302031004/www.bseinquiry.gov.uk/files/yb/1990/08/23001001.pdf

IN CONFIDENCE

So it is plausible pigs could be preclinically affected with BSE but since so few are allowed to reach adulthood this has not been recognised through clinical disease. ...

http://web.archive.org/web/20040904150118/www.bseinquiry.gov.uk/files/yb/1990/08/23002001.pdf

CONFIDENTIAL

EXPERIMENTAL PORCINE SPONGIFORM ENCEPHALOPATHY

While this clearly is a cause for concern we should not jump to the conclusion that this means that pigs will necessarily be infected by bone and meat meal fed by the oral route as is the case with cattle. ...

http://web.archive.org/web/20031026000118/www.bseinquiry.gov.uk/files/yb/1990/08/23004001.pdf

we cannot rule out the possibility that unrecognised subclinical spongiform encephalopathy could be present in British pigs though there is no evidence for this: only with parenteral/implantable pharmaceuticals/devices is the theoretical risk to humans of sufficient concern to consider any action.

http://web.archive.org/web/20030822031154/www.bseinquiry.gov.uk/files/yb/1990/09/10007001.pdf

May I, at the outset, reiterate that we should avoid dissemination of papers relating to this experimental finding to prevent premature release of the information. ...

http://web.archive.org/web/20030822052332/www.bseinquiry.gov.uk/files/yb/1990/09/11005001.pdf

3. It is particularly important that this information is not passed outside the Department, until Ministers have decided how they wish it to be handled. ...

http://web.archive.org/web/20030822052438/www.bseinquiry.gov.uk/files/yb/1990/09/12002001.pdf

But it would be easier for us if pharmaceuticals/devices are not directly mentioned at all. ...

http://web.archive.org/web/20030518170213/www.bseinquiry.gov.uk/files/yb/1990/09/13004001.pdf

Our records show that while some use is made of porcine materials in medicinal products, the only products which would appear to be in a hypothetically ''higher risk'' area are the adrenocorticotrophic hormone for which the source material comes from outside the United Kingdom, namely America China Sweden France and Germany. The products are manufactured by Ferring and Armour. A further product, ''Zenoderm Corium implant'' manufactured by Ethicon, makes use of porcine skin - which is not considered to be a ''high risk'' tissue, but one of its uses is described in the data sheet as ''in dural replacement''. This product is sourced from the United Kingdom.....

http://web.archive.org/web/20030822054419/www.bseinquiry.gov.uk/files/yb/1990/09/21009001.pdf

BSE TO PIGS NEWS RELEASE

http://web.archive.org/web/20030822162313/www.bseinquiry.gov.uk/files/yb/1990/09/24001001.pdf

CONFIDENTIAL

BSE: PRESS PRESENTATION

http://web.archive.org/web/20030822160958/www.bseinquiry.gov.uk/files/yb/1990/09/20003001.pdf

http://web.archive.org/web/20040623191707/www.bseinquiry.gov.uk/files/yb/1990/09/24013001.pdf

http://web.archive.org/web/20030820195733/http://www.bseinquiry.gov.uk/files/yb/1990/09/20010001.pdf

http://web.archive.org/web/20030820195733/http://www.bseinquiry.gov.uk/files/yb/1990/09/25013001.pdf

http://web.archive.org/web/20030820195733/http://www.bseinquiry.gov.uk/files/yb/1990/09/25015001.pdf

INDUSTRY RESPONSE TYPICAL

http://web.archive.org/web/20030822055917/www.bseinquiry.gov.uk/files/yb/1990/09/25007001.pdf

DEFENSIVE BRIEFING

http://web.archive.org/web/20030820195733/http://www.bseinquiry.gov.uk/files/yb/1990/09/25016001.pdf

CONFIDENTIAL

pigs & pharmaceuticals

http://web.archive.org/web/20010305223234/www.bseinquiry.gov.uk/files/yb/1990/09/10007001.pdf

http://web.archive.org/web/20010305223234/www.bseinquiry.gov.uk/files/yb/1990/08/23002001.pdf

http://web.archive.org/web/20010305223234/www.bseinquiry.gov.uk/files/yb/1990/08/23004001.pdf

http://web.archive.org/web/20010305223234/www.bseinquiry.gov.uk/files/yb/1990/08/29003001.pdf

COMMERCIAL IN CONFIDENCE COMMITTEE ON SAFETY OF MEDICINE NOT FOR PUBLICATION BOVINE SPONGIFORM ENCEPHALOPATHY WORKING GROUP

There are only two products using porcine brain and these use corticotrophin BP, made from porcine pituitary, source from outside the UK.............

http://web.archive.org/web/20040622220349/www.bseinquiry.gov.uk/files/yb/1990/10/31003001.pdf

snip...

7 OF 10 LITTLE PIGGIES WENT ON TO DEVELOP BSE;

1: J Comp Pathol. 2000 Feb-Apr; 122(2-3): 131-43. Related Articles,

The neuropathology of experimental bovine spongiform encephalopathy in the pig.

Ryder SJ, Hawkins SA, Dawson M, Wells GA.

Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK.

In an experimental study of the transmissibility of BSE to the pig, seven of 10 pigs, infected at 1-2 weeks of age by multiple-route parenteral inoculation with a homogenate of bovine brain from natural BSE cases developed lesions typical of spongiform encephalopathy. The lesions consisted principally of severe neuropil vacuolation affecting most areas of the brain, but mainly the forebrain. In addition, some vacuolar change was identified in the rostral colliculi and hypothalamic areas of normal control pigs. PrP accumulations were detected immunocytochemically in the brains of BSE-infected animals. PrP accumulation was sparse in many areas and its density was not obviously related to the degree of vacuolation. The patterns of PrP immunolabelling in control pigs differed strikingly from those in the infected animals.

PMID: 10684682 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query...p;dopt=Abstract

snip...

WEDNESDAY, APRIL 05, 2017

Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease

http://chronic-wasting-disease.blogspot.com/2017/04/disease-associated-prion-protein.html

terry

There very well may be a lot I'm behind on, the last article I read on it, which admittedly was last year said the only in vivo test available at that time involved something with mice, and was therefore not practical on any kind of large scale. I was, however aware that deer were being killed for testing, to say that they are being killed and dumped without including that it was for testing is to imply that it's something that it's not. That being said, if TPWD is in fact killing deer that could be tested reliably alive, that makes absolutely no sense and should be looked into. Do they have a stated rationale for doing this?

Again as I know squatt about anything. From what I have seen in over 70 years of observations is that when ever there are studies to be done. Whenever there are grants to be had. Whenever science is involved and monies are available to be used.

There is very seldom a clear cut solution or end to the problem. If there was too many would have to look for work elsewhere.

Cheer up flounder, you can become a vegetarian and find a new hobby and relieve all the stress you are dealing with.

Myself, I will continue to enjoy venison and pork.

Flounder has 4 secretaries working full-time with overtime to come up with all of this info. I would have no idea where to look for all of this stuff.

http://tvmdl.tamu.edu/2016/08/19/tpwd-al...-now-available/

"TPWD alerts deer breeders TVMDL is USDA live testing approved"

Texas Mountain Ranch had to kill all the deer in it's pens and then had to kill all the deer on the ranch. Make no mistake not all deer and elk killed there were tested. They are one of 3 ranches that had to kill every deer on their ranch (not just in pens). Texas mountain ranch was the largest distributor of deer in the state. Every deer that they could track down at hundreds of different breeding facilities that came from TMR was killed to test. If you couldn't supply perfect records or the animal that came from TMR you had to kill 10-20% of your animals to get tier one certified. Those animals were tested.

But most killed on ranches outside breeder pens were just slaughtered and buried by the state. They compensated breeders up to 3 grand for breeder bucks worth many times that amount, but you can see how they bankrupted their budget with that protocol.

So obviously you contend that their "scorched earth" policy is overkill, and it probably is, but how do you find a level of action that is enough without being overkill? As I've stated twice already in this thread, the reaction when BSE transmitted into vCJD was crazy extreme. I know that there are no indications at present that CWD is going to jump, but they were telling people the same thing about BSE back then.

There's no doubt about it, it's a bad situation all around, and the impact it's already had on the deer industry in this state is plenty reason enough to have concern over it's presence. Hopefully things will moderate going forward, and fair policies and strategies for containment will be developed.

In the meantime I suggest you guys contact your state reps and insist on more research involving EHD and anthrax, or join a deer breeders association and lobby them to fund the research you want, and don't depend on government and political agendas to get the solutions you need. Governmental solutions are rarely efficient or equitable.

Containment? It's in wild herds. 75% of the locations in Texas are wild herds. You simply do not "contain" CWD. I don't "think" their protocol is "overkill". I know it's wasted money and effort.

I know that since it only kills an animal 5-7 years into infection, when the average lifespan of a wild deer is 3 years, it is impossible for it to ever decimate a wild herd. I know that since hunters aren't dropping like flies, that it isn't infecting humans.

And I'm already involved. I've asked tpwd officials at listening sessions why the effort to "control" CWD when it's an insignificant threat to wild herds (based on decades of data). And continue to work through my legislators.

They have no credible answer to the above question, and it's blatantly obvious they are a beaurocracy intent on using public fear to shore up their power and funding. Nothing more.

Let's not forget the power of and funding from the anti hunting / animal rights zealots.