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Re: CWD in Texas [Re: Frio County Hunts] #5821939 07/08/15 12:16 AM
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Genetic resistance to Scrapie in sheep, is well known and described, it's not a huge leap to think that some lines of deer will also be naturally resistant. The trans species barrier between humans and CWD is significant, but understanding how the barrier was breached, with BSE is important. The process of virulence amplification created by processing sick cattle and sheep into cattle feed is cautionary. Basically, each generation that got directly infused in to cattle through feed, without being exposed to environmental degradation, got a little more infectious until it breached the species barrier.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: therancher] #5821961 07/08/15 12:25 AM
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Originally Posted By: therancher
Originally Posted By: La Longue Carabine
You posted an abstract elsewhere that was pretty disconcerting. However I cannot find the full article anywhere online. If you come across it, please post it. Here was the abstract:

"Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. ***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection."


Sweet Geezus. Would you please get with the program?! Mr tx_biologist has already established that Alzheimer's is caused by CWD. loser8



That is not impossible. Although other prions are more likely. We won't know until people actually start getting tested

Re: CWD in Texas [Re: flounder] #5821969 07/08/15 12:31 AM
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Originally Posted By: flounder

*** PPo3-7: Prion Transmission from Cervids to Humans is Strain-dependent

*** Here we report that a human prion strain that had adopted the cervid prion protein (PrP) sequence through passage in cervidized transgenic mice efficiently infected transgenic mice expressing human PrP,

*** indicating that the species barrier from cervid to humans is prion strain-dependent and humans can be vulnerable to novel cervid prion strains.

PPo2-27:

Generation of a Novel form of Human PrPSc by Inter-species Transmission of Cervid Prions

*** Our findings suggest that CWD prions have the capability to infect humans, and that this ability depends on CWD strain adaptation, implying that the risk for human health progressively increases with the spread of CWD among cervids.

PPo2-7:

Biochemical and Biophysical Characterization of Different CWD Isolates

*** The data presented here substantiate and expand previous reports on the existence of different CWD strains.

https://www.landesbioscience.com/journals/prion/Prion4-3-PPo2.pdf

Envt.07:

Pathological Prion Protein (PrPTSE) in Skeletal Muscles of Farmed and Free Ranging White-Tailed Deer Infected with Chronic Wasting Disease

***The presence and seeding activity of PrPTSE in skeletal muscle from CWD-infected cervids suggests prevention of such tissue in the human diet as a precautionary measure for food safety, pending on further clarification of whether CWD may be transmissible to humans.

http://www.landesbioscience.com/journals/prion/Prion5-Supp-PrionEnvironment.pdf?nocache=1333529975

>>>CHRONIC WASTING DISEASE , THERE WAS NO ABSOLUTE BARRIER TO CONVERSION OF THE HUMAN PRION PROTEIN<<<

*** PRICE OF CWD TSE PRION POKER GOES UP 2014 ***

Transmissible Spongiform Encephalopathy TSE PRION update January 2, 2014

Wednesday, January 01, 2014

Molecular Barriers to Zoonotic Transmission of Prions

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

http://wwwnc.cdc.gov/eid/article/20/1/13-0858_article.htm

http://chronic-wasting-disease.blogspot.com/2014/01/molecular-barriers-to-zoonotic.html


kind regards, terry


Is this suppose to mean something? Mice experiments? You guys are way out in lala land if you think this latest research is going to make me or anybody like me stop eating venison because it might have CWD. If it does indeed turn out to be factual that this disease takes years to show the symptoms of the disease you are delusional to believe that deer haven't already been killed and eaten that would of tested positive.


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Re: CWD in Texas [Re: Pitchfork Predator] #5821993 07/08/15 12:41 AM
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Originally Posted By: Pitchfork Predator


Is this suppose to mean something? Mice experiments? You guys are way out in lala land if you think this latest research is going to make me or anybody like me stop eating venison because it might have CWD. If it does indeed turn out to be factual that this disease takes years to show the symptoms of the disease you are delusional to believe that deer haven't already been killed and eaten that would of tested positive.


They aren't normal mice. They're transgenic mice. They have been genetically altered, most likely to have proteins like that of humans, so that researchers can see if the prions can induce changes in human proteins. I have no doubt that people in CWD infected regions have eaten CWD infected meat. But Texas has not yet been identified as on of those regions. So, the question being addressed now is whether it is wise to stop eating wild game before CWD spreads throughout Texas.

It's incredibly depressing. I don't want to give it up. But I don't want dementia even more.

Re: CWD in Texas [Re: Frio County Hunts] #5822003 07/08/15 12:45 AM
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Re: CWD in Texas [Re: jmh004] #5822006 07/08/15 12:45 AM
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Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But in the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.

Last edited by La Longue Carabine; 07/08/15 12:50 AM.
Re: CWD in Texas [Re: La Longue Carabine] #5822009 07/08/15 12:48 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: Pitchfork Predator


Is this suppose to mean something? Mice experiments? You guys are way out in lala land if you think this latest research is going to make me or anybody like me stop eating venison because it might have CWD. If it does indeed turn out to be factual that this disease takes years to show the symptoms of the disease you are delusional to believe that deer haven't already been killed and eaten that would of tested positive.


They aren't normal mice. They're transgenic mice. They have been genetically altered, most likely to have proteins like that of humans, so that researchers can see if the prions can induce changes in human proteins. I have no doubt that people in CWD infected regions have eaten CWD infected meat. But Texas has not yet been identified as on of those regions. So, the question being addressed now is whether it is wise to stop eating wild game before CWD spreads throughout Texas.

It's incredibly depressing. I don't want to give it up. But I don't want dementia even more.


Parts of West Texas ARE identified as part of those regions. 7 wild free ranging animals so far have been found POSITIVE for CWD in the transpecos area.





Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: La Longue Carabine] #5822015 07/08/15 12:50 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOBO the Clown] #5822019 07/08/15 12:52 AM
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Originally Posted By: BOBO the Clown


Parts of West Texas ARE identified as part of those regions. 7 animals so far have been found POSITIVE for CWD in the transpecos area.





Yes I am aware, but it wasn't significant enough to count the whole state as a CWD region

Re: CWD in Texas [Re: La Longue Carabine] #5822027 07/08/15 12:55 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But in the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.

Here is an interesting read...notice the live testing results and the factual replies to the unknowns listing a lot of factors that could be the reasons for the decline...also the deaths number or how they died...interesting to see actual research being done on live deer and live deer testing.
http://billingsgazette.com/news/state-an...07ea837cde.html


Are idiots multiplying faster than normal people?[Linked Image]
Re: CWD in Texas [Re: BOBO the Clown] #5822044 07/08/15 01:02 AM
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Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?

The South Converse Herd was part of the original cwd detection area

Re: CWD in Texas [Re: La Longue Carabine] #5822049 07/08/15 01:05 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown


Parts of West Texas ARE identified as part of those regions. 7 animals so far have been found POSITIVE for CWD in the transpecos area.





Yes I am aware, but it wasn't significant enough to count the whole state as a CWD region


That because most maps are NOT putting whole states as a region. They are put geographic areas as regions with in states. On top of that most maps haven't been update since 2013. Let's not forget the geographical size of Texas on top of that

That number alone suggest 10-15% CWD rate on that range.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: La Longue Carabine] #5822055 07/08/15 01:05 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?

The South Converse Herd was part of the original cwd detection area


And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5822070 07/08/15 01:11 AM
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Come on Doc keep googling!!!! We need more pitchforks


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOBO the Clown] #5822077 07/08/15 01:16 AM
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Originally Posted By: BOBO the Clown
And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


If this herd has the highest CWD infection rate of any population, and their population is declining faster than any other population . . . then there is probably an obvious logical connection there.

Last edited by La Longue Carabine; 07/08/15 01:17 AM.
Re: CWD in Texas [Re: Frio County Hunts] #5822155 07/08/15 01:54 AM
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It's funny how people describe hunting. I guided the wealthiest people in the world, including a King while on the King Ranch, which is low fence, and every time I am the one who knew where the deer was and took the hunter to the location and all they did was pull the trigger or release the arrow. Same thing while guiding Elk in Colorado and Canada. I did the scouting and I knew where the Elk were and again, all the hunter did was pull the trigger. I have also had guests that think High Fence hunting is something that they would never do until they couldn't get the animal that they were after and then would go to a neighboring High Fence place to look around and almost always ended up going back to hunt.
I love how we are fast to judge. This is America, let folks hunt as they will. A true trophy is in the eye of the Hunter! If you don't like it then don't do it but don't tell landowners what they can or can't do on their own property or else you are communist and just haven't accepted it yet.
TPWD should be working these folks to better the entire state. All they are about is Power, period. The corrupt and powerful always feel the need for more Power, no matter who they destroy to get it.

Re: CWD in Texas [Re: Frio County Hunts] #5822167 07/08/15 01:59 AM
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Mule Deer populations have been going down for decades now. Drought is a big culprit, habitat destruction, other species taking over. But, sure lets just say it's all CWD. After all, there can only be one reason for anything that happens in nature right?

http://www.texashunting411.com/mule-deer-population-boosted-at-black-gap-wma/

Re: CWD in Texas [Re: Frio County Hunts] #5822182 07/08/15 02:03 AM
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Sorry, my last response was for JMalin. Again, sorry THF, I just really get frustrated with Communism thinking.

Re: CWD in Texas [Re: Bowman24] #5822196 07/08/15 02:07 AM
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Well said

Re: CWD in Texas [Re: La Longue Carabine] #5822218 07/08/15 02:15 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown
And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


If this herd has the highest CWD infection rate of any population, and their population is declining faster than any other population . . . then there is probably an obvious logical connection there.


What I find interesting is your ignoring the other 30 plus areas with CWD. Some one such as your self that is highly interested in CWD as of a few THF days ago...would exclude non CWD type morality , expecially in a state that has a 90% migration rate, or a desert area that's also fighting Feds over sage grouse regulations and habitat conservation.

With out the historical environmental tends in front of you I guess:
1)it's easy to say yelp it's all CWD
2) CWD explains low recruitment in sage grouse also... No other reseasonable explanation.
3) don't know why all the other CWD hot spots are holding population numbers and/or swing with envorimental trends but this one should be used as an example of what's going to for sure happen....

Fact of the matter is we are now 67 years into the classification of CWD being a clinical disease. That particular area in Wyoming is now 36 years into the discovery of CWD there( which no one still knows if it was imported or finally identified).... We still have deer, we still have elk.

How is Wisconsin deer herd doing now?


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Bowman24] #5822225 07/08/15 02:18 AM
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Originally Posted By: Bowman24
It's funny how people describe hunting. I guided the wealthiest people in the world, including a King while on the King Ranch, which is low fence, and every time I am the one who knew where the deer was and took the hunter to the location and all they did was pull the trigger or release the arrow. Same thing while guiding Elk in Colorado and Canada. I did the scouting and I knew where the Elk were and again, all the hunter did was pull the trigger. I have also had guests that think High Fence hunting is something that they would never do until they couldn't get the animal that they were after and then would go to a neighboring High Fence place to look around and almost always ended up going back to hunt.
I love how we are fast to judge. This is America, let folks hunt as they will. A true trophy is in the eye of the Hunter! If you don't like it then don't do it but don't tell landowners what they can or can't do on their own property or else you are communist and just haven't accepted it yet.
TPWD should be working these folks to better the entire state. All they are about is Power, period. The corrupt and powerful always feel the need for more Power, no matter who they destroy to get it.


I agree whole hearty!!! But this is about CWD in Texas and America not so much HF, LF or No fence. up


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5822257 07/08/15 02:34 AM
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CWD really might be more serious than we all believe. Think about all these decisions that have happened in DC recently. Is it possible that CWD has infected the grounds of the White House and the Supreme Court? I mean that would explain a lot right??

Last edited by jmh004; 07/08/15 02:35 AM.
Re: CWD in Texas [Re: jmh004] #5822282 07/08/15 02:50 AM
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Originally Posted By: jmh004
CWD really might be more serious than we all believe. Think about all these decisions that have happened in DC recently. Is it possible that CWD has infected the grounds of the White House and the Supreme Court? I mean that would explain a lot right??


CWD is a serious disease with out a doubt!!!!!

It's just not the apocalypse. You have to remember they identified it in 60's. They have mapped it back almost as far as the early 1900's they just now if it was already here or transferred/morphed from sheep some how.

Nature has a funny way of covering stuff up and also working its self out.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOBO the Clown] #5822286 07/08/15 02:52 AM
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Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?




to date, officials claim it to be the normal (their normal) one in a million i.e. sporadic CJD.


but ;


*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).

https://www.landesbioscience.com/journals/prion/article/28124/?nocache=112223249


so there goes the neighborhood...


terry

Re: CWD in Texas [Re: BOBO the Clown] #5822309 07/08/15 03:01 AM
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That was just my attempt at a little comic relief for this thread.

Last edited by jmh004; 07/08/15 03:02 AM.
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