Except for Nov - Dec I shoot long range almost every weekend, so mine stay ready. Squeaky clean is less accurate by far in all of my rifles. I ALWAYS foul them after cleaning.
Shot from the bench at 100 on Saturday for the first time in a couple of months.
Tikka CTR 260 Rem = 3 shots 3/8 inch
Savage custom 7 Rem Mag = 4 shots - 3 shots in one hole and had a 3/4 inch flyer on shot #2. No idea why? Probably operator error but I usually catch those and call it, but I missed this one.
Remington custom 25-06 = 3 shots 3/4 inch. This rifle has been a problem child since day 1. Took months to work up a sub MOA load. At least it will shoot MOD (Minute of Deer).
I forgot to mention I will be taking it out to the range before I go hunting. I have been told to clean then shoot, not the other way around.
My recommendation is to clean it, go to the range and fire at least 3 - 5 shots, let the barrel cool back to air temp, then shoot for a group and adjust scope if needed. Your rifle should be good for quite a few rounds before it needs cleaning again.
My most frequently cleaned rifle is my 7 mag. It likes to be cleaned about every 100 - 150 rounds. Most of my other rifles are good for 300+ rounds. How do I know when it's time to clean? Well, like I said I shoot a lot. On a calm day I expect to shoot a 3 to 4 inch group at 600 yards. When my groups start opening up, it's time to clean. The 7 mag gets cleaned about 4 times per year and the others 2 or 3 times.
This works well for people who shoot often. For those that don't, cleaning once a year before the season, quickly fouling the barrel with 3-5 shots, then shooting a group, will work.