Are you bow hunting or gun hunting?
gun for now, probably do some clearing before bow season next year
OK. So I hunt northeast Texas hardwood and cedar forest with thick underbrush and have always tried to keep in mind that wildlife, much like humans, tend to travel the path of least resistance. Learn those paths well. They may not necessarily be "the trail", but the animal will likely funnel via instinct to those paths. And obviously, you don't need to do this if you never lose visual. This knowledge has helped us locate more downed animals than any other knowledge. When I get off track, I go back to the last place I saw the deer and start over. Look for blood up to about 5 foot high on the brush and trees, not just on the ground. Also, after the shot, be sure to open your ears and listen very closely because the animal may tend to crash and bang off of trees and brush, thereby giving you an indication of direction of travel. It is a skill that takes time to develop but it is very useful and makes the experience more fulfilling.
Red Cloud's tip above is a good tip and goes along with what I am explaining.
I wouldn't do too much clearing or you may run out much of what is there.
Shot placement, weapon, optics, caliber, ammunition type, etc. is all largely a matter of preference no matter where you are hunting and you should have that all figured out before you leave home. Much of the advice here seems to be geared towards shot placement to drop the deer in its tracks in order to avoid losing visual which is not a poor tactic if you are confident enough in your abilities. As long as you are proficient at delivering a fatal shot that kills the animal within a 100 yard radius, you task will be far easier. In my experience, when they make it further than about 100 yards, it gets progressively to exponentially more difficult to locate a downed animal in thick cover.
Good luck to you.