I've taken game with both my Blackhawk .357 mag. shooting 158 gr. JHP and 158 gr. SWC and my .44 mag. Super Blackhawk 240 gr. JHP. Had excellent results with both, open sights, especially the .357 on mountain lion, coyotes, impala (60 yds. in Africa). .44 mag. deer and prairie dogs.
Know your trajectory!! Good luck.