I'm a wildlife biologist/consultant and a "student of deer", now I can throw "student of quail" in there after completing the Quail Masters course. It doesn't appear that based on this pretty solid data that culling is effective. There are alternatives though to managing a herd to increase the quality of antler growth.
That study keeps being trotted out almost as often as the spike study, but it really is limited in scale and duration.
Selective shooting can alter genetics given enough scale and time. The best example of that is that quality deer were "shot out" of areas, in essence culling the best out of the population producing a long-term downward trend in areas that previously had very large racked deer. The same can happen in a positive direction given large scale application at the state level and decades and decades of sustained effort.
Bill Maltsberger began heavy management of his deer in the late '60's and early '70's. Body weights and average rack sizes increased steadily over the next 40 years according to his records for the deer on his ranch.
When you shot out a ranch you shot out what dispersed to the area, you change the "shot out mentality" and get age structure back you will go back to having big deer.
All culling does is protect a certain deer to maturity while not allowing the cull to mature and stress the land scape. It would take years and years of top end protection and intense culling to even begin to influence genetics. Very few have that thirst for blood or resources.
My old ranch was shot out and age structure depressed. At the time I took the deed we where at established 1 to 150 acres. With in 5 years we had kill a net AT net BC, with in 7 we Had two net AT BC " and up 1 deer per 75 acres. We also increase managed acreage by two fold
There where no changes genetic wise. Just like releasing breeders, the natural genetic will wash out the breeders in a few generations, if you stop releasing breeders.
Very few ranches as a whole have the resources to cull for the true top end exceptions.
If culling changed genetics, there would be an end point on the bottom and unlimited growth at the top.
You will always be culling and still won't get to 300", but by culling you cheapen back feed and make sure your topend has most groceries, also reduce pressure on habitat thus increase health