I highly recommend that you stay in Marathon, at the Gage Hotel. The White Buffalo Bar was memorable. Last time we were there, the restaurant was terrific. And a short stay at the Lajitas golf resort was nice.
Buddy just got back from there and the region is really scared of COVID. Could only order drinks inside bar, and had to consume outside. I would hit the Riata in Alpine and Starlight theater in Terlingua. Don’t know if La Kiva ever open up again?