I am looking at the falken wildpeak tires and heard that they loose 2 miles per gallon running them on a f-150 does anybody running these tires and is it true also how do you like them

I run them on my f150 eco boost 4wd. I run 33s with a leveling kit and get 15-17.

Really depends. More aggressive usually means more rubber hitting the ground so yeah they may loose a little bit 2 mpg sounds excessive. One thing I remember is they seemed heavier than some other brands but I’ve been away from the tire business almost 3 years now.

If you keep it the same size I don't think you will loose anything.

If you go bigger/smaller your speedometer and odometer will be off if you do not get them recalibrated as will your computer generated fuel economy.

If you use same size and they are much heavier, they will hurt your MPG in stop and go situations.
On the highway, not so much once you are rolling.