Figure out your holds. A duplex reticle trick is to zero at 100 yards, at the bottom point of the top heavy post. Then you have 5 elevation holds.
1. Bottom of the 12 o'clock post
2. Halfway from the 12 o'clock to center
4. Halfway from center to the 6 o'clock post
5. Top of the 6 o'clock post
That may just get you to 350 yards, depending on what cartridge you're shooting.
Prairie dogs live where it is windy. You'll have to see a round splash, and make a correction based on the splash. Little tricky, but do-able.