I have a new Stryker Strikezone 380 that I can't get the safety to disengage. I pull the string all the way beyond click and seat the bolt back as far as I can and it still won't release the safety. The safety button will slide forward but it won't stay. In order to fire the bow I have to hold the safety forward and pull the trigger at the same time. Beyond frustrated!

That sounds like a very dangerous safety issue and I think you need a professional to look at it. Honestly, I would return it to the manufacturer for service.

That is a known issue with Stryker 380 crossbows. Your dealer should be able to get fixed but most will return it to Stryker for the repair