Derrick at Horizon has been running the PRC a while and taken a few animals with it with both 143 and 147 gr bullets. I have been playing with the 6.5/284 which is pretty much the same ballistically and the 6.5 SAUM which definitely has more horsepower. All have more recoil and burn more powder than Creedmoor so up to the user if they are worth it.
"Anyone taking up handloading necessarily plays with unknown factors and takes chances. But so does anyone who drives a car,goes to a cocktail party,eats in a restaurant,or gets married."
Jack O'Connor 1963