I too have had good success with Reloder 26 in the standard 280 and the Ackley version should also show good performance. It shines with the heavy bullets and the 168gr Berger Classic Hunter or the new 162-175gr ELD would be good choices
I mainly use my .280 as an elk rifle so the heavy bullets is all I have shot. Don't need that much bullet for deer for sure.
I think it was Jack O'Connor that said heck you can throw a soggy donut through most Texas deer