I've run various maker's 2-7 scopes on everything from a .50 cal muzzleloader to 22 lr to small bore centerfire cartridges and up to 300 Win Mags. I currently have ONE Sig scope - a Whiskey 5 3-15.
Just some basics from my experiences;
2-7 for me, works best on my shorter range rifles such as 358 Win. I'm not going to use it out past 200 -300 yards.
The 2-7, again, for me, will work on pretty much any caliber you have, as long as you understand the limitations of the 7x power and the 32mm objective lens.
Since I haven't owned or experienced the Whiskey 3 series scopes only the Whiskey 5, I'll bow out on optics to those that have run with it some. My experiences with the Whiskey 5 have all been very positive.
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