I recently started carrying a Ruger LCR with a Remora no clip holster and I love it!
Very comfy, wear it all day, doesn't bother me while sitting in the car either. If I am in a rush I will carry it appendix, but if I have time I will position it on my strong side.
Don't give me any grief, but its a .22lr...
Its very easy to shoot, has 8 rounds, and is supper light.
I used to laugh at the thought of a .22 until I saw a petite little gal in a training class....... Her normal EDC was a 9mm, but she wanted to train with her tiny .22 for running.
After sprinting, dodging and rolling, she came up fast and put all rounds in the face/neck of a silhouette target at 10 yards - in about 4 seconds. Then she looked me in the eye and said "so, you don't think that would be lethal?" She also commented that the total lack of recoil allowed her to stay on target, compared to the 9mm.
I guess the point is: Practice, training, and attitude are perhaps more important that weapon selection.