Axis die pretty easy. Shoot whatever is most accurate in your rifle. I have a Remington 700 BDL in 30-06 that I spent a lot of time working up a custom load that gave me the best accuracy. I was pretty good with 150 grain bullets, but when I went up to 165 grains, it was much better. When I'm practicing a lot, I can get one inch and groups of five, and a few times I was at 3/4 of an inch. I never got down to one inch with any combinations of bullets and powder with 150 grain bullets.
When I quit reloading, I found that Federal Premium ammo gave me the same results in 165 grain bullets!!!!