I tried quite a few combos.
For a hunting load, settled on:
Barnes 100 gr. TTSX
44.7 H414 (H4350 was nowhere to be found at the time)
Avg 3080 fps
Could run it well beyond 3200, but found good accuracy with DRT results, better than 120 gr. Barnes and 120 Ballistic Tips.
Your IMR 4350 should work fine with 100 gr. TTSX, turn up the powder and velocity. Work up powder charges first, find the best, then test different seating depths. Accuracy with Barnes can be specific to the amount of jump. Try 0.010" for a starting point. Move back 0.010" with 3 shots per length. Don't be surprised if best is 0.050" or more of jump.
Exit wound, note the petal pattern