What I didn't mention in my first comment was that, like any firearm, the bullet choice matters. When I said I'd shot a few, I was only taking about hogs that were not in a pen. I used to trap a lot of hogs of various sizes, and sometimes I'd terminate them with my 22lr lever gun and sometimes with the 357. My standard 357 load was/is a 125 gr JHP, loaded rather hot. But that bullet and load didn't work as well to drop the hogs as a 165 gr lead Keith type bullet at moderate velocity. I observed that, but have no explanation as to why. Based on that observation, I'd think that a 45 ACP load should work great.