DNS advice is spot on, go with what your gun shoots best. It is better to have confidence in the shot (as you said, shot placement is key) than have a larger/heavier bullet that doesn't shoot consistently.
I shoot 55gr soft points out of my AR platform. I have dropped many a hog and some take a second (or third) shot to get them down. It's when I can get a good neck level CNS shot that drops them...when they are running after that first shot all bets are off, and that goes for virtually any bullet you could reliably shoot semiauto in that fashion.