Oh hell yeah. Do that! But make sure you have a properly constructed bullet. Expect entry and expansion but don't count on an exit if you are shooting at any great distance. And as always, shot placement is king.
Loc: Lubbock and Texas
I have killed 10 or so deer with the federal 120 np. All drt and never recovered a bullet. I have some hornady 117 grain but not shot anything with them. If they work for you on deer should be ok also for axis.