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#6030641 - 11/15/15 12:46 PM TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DETECTED
flounder Offline
Woodsman

Registered: 10/29/11
Posts: 175
Loc: 77518
Saturday, November 14, 2015

TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DETECTED

http://chronic-wasting-disease.blogspot.com/2015/11/texas-captive-breeder-chronic-wasting.html

Thursday, November 05, 2015

*** TPW Commission Adopts Interim Deer Breeder Movement Rules

http://chronic-wasting-disease.blogspot.com/2015/11/tpw-commission-adopts-interim-deer.html

Wednesday, March 18, 2015

*** Chronic Wasting Disease CWD Confirmed Texas Trans Pecos March 18, 2015

http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-confirmed.html

Wednesday, March 25, 2015

*** Chronic Wasting Disease CWD Cases Confirmed In New Mexico 2013 and 2014 UPDATE 2015

http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-cases.html

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#6032312 - 11/16/15 10:02 AM Re: TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DETECTED [Re: flounder]
kdkane1971 Offline
Pro Tracker

Registered: 01/30/14
Posts: 1808
Loc: Mesopotamia

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#6032332 - 11/16/15 10:07 AM Re: TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DETECTED [Re: flounder]
stxranchman Offline
Obie Juan Kenobi

Registered: 08/04/10
Posts: 52092
Flounder must not spend much time hunting....he is posting old stuff that he has already posted before.
_________________________


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#6037020 - 11/18/15 10:31 AM Re: TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DETECTED [Re: flounder]
flounder Offline
Woodsman

Registered: 10/29/11
Posts: 175
Loc: 77518
Wednesday, November 18, 2015

TEXAS Mule Deer Outlook Promising; Hunters Reminded of Mandatory CWD Testing

http://chronic-wasting-disease.blogspot.com/2015/11/texas-mule-deer-outlook-promising.html

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#6037030 - 11/18/15 10:39 AM Re: TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DETECTED [Re: flounder]
flounder Offline
Woodsman

Registered: 10/29/11
Posts: 175
Loc: 77518
Wyoming WGF Commission Meeting 11/6/2015 Afternoon Edition Video

CWD starts at minute 58:51 of first hour of meeting discussion of previous models predicting extinction of deer population and elk population.

please mark hour 1:02 where remarks were made about potential resistant genes and prolonged survival, however a recent study (I posted directly next after youtube link) where it states ;

‘’Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. The potential for the generation of novel strains raises the possibility of an expanded host range for CWD. ‘’

hour minute mark 1:03

captive Elk study

39 femail elk calves captured on National Elk Refuge In Jackson, WY

Transported to WGFD Thorne-Williams Wildlife Research Unit (Sybille, TWWRU)

Worst-case scenario for prion exposure

Genotypes

-27 M/M132 (69.2%)

-11 M/L132 (28.2%)

-1 L/L132 (2.6%)

38 of 39 elk died over 10-year study

1 remaining elk was L/L132

still alive and remained negative for PrPCWD by rectal biopsy

Appears healthy, weighs 242kg, and bore healthy calf in May, 2012

CWD infection rate in this study ???

https://www.youtube.com/watch?v=bnlk4kW3fFw

> During the analysis, 37 of 39 elk died, all of which were positive for CWD.

http://www.esajournals.org/doi/pdf/10.1890/ES14-00013.1

*** Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. ***

*** The potential for the generation of novel strains raises the possibility of an expanded host range for CWD. ***

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains

Camilo Duque Velásqueza,b, Chiye Kima,c, Allen Herbsta,b, Nathalie Daudea,d, Maria Carmen Garzaa,e, Holger Willea,e, Judd Aikena,b and Debbie McKenziea,c aCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada bDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada cDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada dDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada eDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

B. Caughey, Editor

+ Author Affiliations

ABSTRACT

Transmission of chronic wasting disease (CWD) between cervids is influenced by the primary structure of the host cellular prion protein (PrPC). In white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild type [wt]), Q95 S96 (referred to as the S96 allele), and H95 G96 (referred to as the H95 allele), which differentially impact CWD progression. We hypothesize that the transmission of CWD prions between deer expressing different allotypes of PrPC modifies the contagious agent affecting disease spread. To evaluate the transmission properties of CWD prions derived experimentally from deer of four PRNP genotypes (wt/wt, S96/wt, H95/wt, or H95/S96), transgenic (tg) mice expressing the wt allele (tg33) or S96 allele (tg60) were challenged with these prion agents. Passage of deer CWD prions into tg33 mice resulted in 100% attack rates, with the CWD H95/S96 prions having significantly longer incubation periods. The disease signs and neuropathological and protease-resistant prion protein (PrP-res) profiles in infected tg33 mice were similar between groups, indicating that a prion strain (Wisc-1) common to all CWD inocula was amplified. In contrast, tg60 mice developed prion disease only when inoculated with the H95/wt and H95/S96 CWD allotypes. Serial passage in tg60 mice resulted in adaptation of a novel CWD strain (H95+) with distinct biological properties. Transmission of first-passage tg60CWD-H95+ isolates into tg33 mice, however, elicited two prion disease presentations consistent with a mixture of strains associated with different PrP-res glycotypes. Our data indicate that H95-PRNP heterozygous deer accumulated two CWD strains whose emergence was dictated by the PrPC primary structure of the recipient host. These findings suggest that CWD transmission between cervids expressing distinct PrPC molecules results in the generation of novel CWD strains.

IMPORTANCE CWD prions are contagious among wild and captive cervids in North America and in South Korea. We present data linking the amino acid variant Q95H in white-tailed deer cellular prion protein (PrPC) to the emergence of a novel CWD strain (H95+). We show that, upon infection, deer expressing H95-PrPC molecules accumulated a mixture of CWD strains that selectively propagated depending on the PRNP genotype of the host in which they were passaged. Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. The potential for the generation of novel strains raises the possibility of an expanded host range for CWD.

http://jvi.asm.org/content/89/24/12362.abstract?etoc

*** Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. ***

*** The potential for the generation of novel strains raises the possibility of an expanded host range for CWD. ***

UPDATE CWD VACCINE ELK minute mark 1:22:00

VACCINE

RECOMBINANT PROTEIN FUSION VACCINE

Hedlin, PD et al ‘’Design and delivery of a cryptic PrP c epitope for induction of Prp Sc-specific antibody responses.’’ Vaccine 28.4 (2010) 981-988.

PAN-PROVINCIAL VACCINE ENTERPRISES (PREVENT)

Dose: 2ml IM CWD VACCINE UPDATE IS A FAILURE, I REPEAT, A NEGATIVE RESULTS FOR CWD VACCINE. .tss

https://www.youtube.com/watch?v=bnlk4kW3fFw

Monday, November 16, 2015

*** Wyoming Latest round of testing CWD surveillance program has found the disease in three new hunt areas

http://chronic-wasting-disease.blogspot.com/2015/11/wyoming-latest-round-of-testing-cwd.html

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