Had the same issue just last month with that exact same ammo in 300 Weatherby. Rifle is a Rifles Inc strata (based on a Remington 700 action) that shoots Weatherby ammo just fine, but not the Nosler trophy grade.
Give Nosler a call, they will trade you for a replacement box. Waiting to hear back on their test results from the box I sent in, but in the meantime I'm back to searching for another factory load. I'll be selling the replacement box they sent me.
If you died tomorrow, what would you have done today...