Should be, IF the shot placement is good. Small bucks/does no problem, but bucks can be extremely tough and bleed very little typically. I seen more than a few big axis buck approach 300lbs.
It depends on your property. I have shot big axis bucks right through the heart, and STILL have them run over a 100-150 yards before falling over dead.
I have taken 6 or 7 axis bucks with my 25-06 and haven't lost one yet - although 2 of them required a second shot to pin the animal. Most of mine have been taken with my .308 - that being said, I had one hop a fence after a 60 yard sprint (not the best shot admittedly, but still a kill). So on that property, where I need to drop them QUICKLY and RIGHT THERE, I have been known to carry my .375 H&H