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CWD in Texas #5815711 07/03/15 03:06 AM
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Re: CWD in Texas [Re: Frio County Hunts] #5815762 07/03/15 03:40 AM
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Are idiots multiplying faster than normal people?[Linked Image]
Re: CWD in Texas [Re: Frio County Hunts] #5815936 07/03/15 12:50 PM
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Gracias STXRM

Re: CWD in Texas [Re: Frio County Hunts] #5816781 07/04/15 02:45 AM
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How many deer have died because of cwd in Texas breeding pens?

Re: CWD in Texas [Re: jmh004] #5816789 07/04/15 02:49 AM
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Originally Posted By: jmh004
How many deer have died because of cwd in Texas breeding pens?


Directly---To date zero

In directly as a political tool... Hundreds


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5817086 07/04/15 01:44 PM
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I believe the deer in question in Medina County didn't even die from cwd. Apparently he jumped into the fence and broke his neck.

Re: CWD in Texas [Re: Frio County Hunts] #5817985 07/05/15 07:34 AM
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This is a very serious problem. 40 animal transfers have been made in Texas from what is now an identified CWD infected site. It is unclear as to whether any of those 40 locations made any animal transfers afterwards. Given the persistance of CWD in the environment (outside the host), and considering the large number of now suspected locations, it is likely that CWD will have a continuing presence in Texas. The ramifications of this would be quite extensive. Millions of dollars of deer will probably be killed, and if any evidence that the disease has spread beyond high fenced ranches in the whitetail population is found, then it is likely that we may see a ban on any kind of baiting for whitetail hunting in those regions (as is the case with Wisconsin).Not to mention the loss of whitetail deer as a food source in those areas.

Re: CWD in Texas [Re: Frio County Hunts] #5818167 07/05/15 03:30 PM
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I disagree. EHD is much more prevelant in the state. It kills thousands of deer a year, and has been around forever, and no one is freaking out over that. Colorado spent $80 million on how to stop CWD, and they figured out that it wasn't that big of a deal. Colorado now has 0 regulations on CWD. Heck, there are scientist at A&M that say CWD may not even be transferable to other deer.I think TPWD will try to use this as a way of getting more control of the deer breeding industry. Just do a little research for yourself on CWD, and try not to get your information from The Outdoor Channel.

Re: CWD in Texas [Re: jmh004] #5818358 07/05/15 07:00 PM
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I'm a Dr and I have a reasonably good understanding of prions, EHD, and CWD. There is certainly no shortage of literature and studies that demonstrate that CWD is definitely infectious among other deer and cloven hooved ungulates, but it is also being discovered that it can infect an ever growing list of other species. It has a larger reservoir that EHD, represented by these other species (including agriculture), and that is why there is increasing concern over it. Yes, EHD may be more virulent than CWD. But mortality with CWD is 100%. That coupled with it's persistance in the environment make it a serious concern.

Re: CWD in Texas [Re: jmh004] #5818360 07/05/15 07:03 PM
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Then how did this one have it?
Originally Posted By: jmh004
Heck, there are scientist at A&M that say CWD may not even be transferable to other deer.


Originally Posted by ImTheReasonDovesMourn
I'd ask him if he's pregnant. He missed a s__tload of periods.

Originally Posted by Hancock
I'll take "things that look like a uterus" for $200 Alex.
Re: CWD in Texas [Re: Frio County Hunts] #5818369 07/05/15 07:11 PM
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So where exactly has there been a massive die of deer from CWD? From the disease, not from a state coming in and massacring hundreds or thousands of animals because one was sick.

Re: CWD in Texas [Re: jmh004] #5818416 07/05/15 07:59 PM
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CWD is a slow and horrible death that takes years. Many (maybe most) that have it were killed by humans in an attempt to stop it from spreading.

Re: CWD in Texas [Re: Frio County Hunts] #5818427 07/05/15 08:07 PM
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So your saying there have been 0 massive die offs from CWD? Sounds like state wildlife departments have killed about 100X more deer than CWD. So we are suppose to loose our minds over something that hasn't even shown it kills in large numbers. All this is, is a case of tpwd wanting to take down a multi billion dollar deer industry that it is envious of.

Re: CWD in Texas [Re: jmh004] #5818438 07/05/15 08:20 PM
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Originally Posted By: jmh004
So your saying there have been 0 massive die offs from CWD? Sounds like state wildlife departments have killed about 100X more deer than CWD. So we are suppose to loose our minds over something that hasn't even shown it kills in large numbers. All this is, is a case of tpwd wanting to take down a multi billion dollar deer industry that it is envious of.


Mk . . .

Re: CWD in Texas [Re: Frio County Hunts] #5818451 07/05/15 08:40 PM
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What has killed more deer in North America, CWD or wildlife agencies?

Re: CWD in Texas [Re: La Longue Carabine] #5818823 07/06/15 01:37 AM
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Originally Posted By: La Longue Carabine
This is a very serious problem. 40 animal transfers have been made in Texas from what is now an identified CWD infected site. It is unclear as to whether any of those 40 locations made any animal transfers afterwards. Given the persistance of CWD in the environment (outside the host), and considering the large number of now suspected locations, it is likely that CWD will have a continuing presence in Texas. The ramifications of this would be quite extensive. Millions of dollars of deer will probably be killed, and if any evidence that the disease has spread beyond high fenced ranches in the whitetail population is found, then it is likely that we may see a ban on any kind of baiting for whitetail hunting in those regions (as is the case with Wisconsin).Not to mention the loss of whitetail deer as a food source in those areas.

I sure hope your info on the 40 numbers is correct and what I have been told is false since my redneck contacts are saying different.
Originally Posted By: La Longue Carabine
I'm a Dr and I have a reasonably good understanding of prions, EHD, and CWD. There is certainly no shortage of literature and studies that demonstrate that CWD is definitely infectious among other deer and cloven hooved ungulates, but it is also being discovered that it can infect an ever growing list of other species. It has a larger reservoir that EHD, represented by these other species (including agriculture), and that is why there is increasing concern over it. Yes, EHD may be more virulent than CWD. But mortality with CWD is 100%. That coupled with it's persistance in the environment make it a serious concern.

Humor me then since I am just a dumb redneck. Do you have a link(s) and pics of this 100% mortality from CWD so I can see it? I have looked and looked without any luck. I can't find one pic of a dead animal that died from CWD. I can find info on slaughters of large numbers of deer with a small % testing postive in wild deer. I can also find examples of the slaughter of deer in breeding pens that were suspected of CWD and killed for that reason, but none of them ever tested postive for CWD. If CWD is being found in more than just deer then why stop at the slaughter of just deer in the pens or in the wild then? I would think every species of animal within that ranch or those counties should be slaughtered that might be a carrier at this point, correct?
Originally Posted By: La Longue Carabine
CWD is a slow and horrible death that takes years. Many (maybe most) that have it were killed by humans in an attempt to stop it from spreading.

So does CWD occur only in locations where all the animals that have it are killed or are you are saying that there are animals deaths from CWD 100% the time before the slaughter starts? If so can you provide links to clarify. Again sorry just a redneck so I need more detailed info at to this 100% mortality.
I consider any disease to humans, wildlife or livestock serious. This first case of WT with CWD is serious, but to me how it got to Central Texas is even more serious at this point. Since other animals stand the same chance of getting it just as this deer has until we find out how it got here. I do not always take what is written on any forum 100% truthful without asking questions.


Are idiots multiplying faster than normal people?[Linked Image]
Re: CWD in Texas [Re: stxranchman] #5819130 07/06/15 06:18 AM
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Originally Posted By: stxranchman
Originally Posted By: La Longue Carabine
This is a very serious problem. 40 animal transfers have been made in Texas from what is now an identified CWD infected site. It is unclear as to whether any of those 40 locations made any animal transfers afterwards. Given the persistance of CWD in the environment (outside the host), and considering the large number of now suspected locations, it is likely that CWD will have a continuing presence in Texas. The ramifications of this would be quite extensive. Millions of dollars of deer will probably be killed, and if any evidence that the disease has spread beyond high fenced ranches in the whitetail population is found, then it is likely that we may see a ban on any kind of baiting for whitetail hunting in those regions (as is the case with Wisconsin).Not to mention the loss of whitetail deer as a food source in those areas.

I sure hope your info on the 40 numbers is correct and what I have been told is false since my redneck contacts are saying different.
Originally Posted By: La Longue Carabine
I'm a Dr and I have a reasonably good understanding of prions, EHD, and CWD. There is certainly no shortage of literature and studies that demonstrate that CWD is definitely infectious among other deer and cloven hooved ungulates, but it is also being discovered that it can infect an ever growing list of other species. It has a larger reservoir that EHD, represented by these other species (including agriculture), and that is why there is increasing concern over it. Yes, EHD may be more virulent than CWD. But mortality with CWD is 100%. That coupled with it's persistance in the environment make it a serious concern.

Humor me then since I am just a dumb redneck. Do you have a link(s) and pics of this 100% mortality from CWD so I can see it? I have looked and looked without any luck. I can't find one pic of a dead animal that died from CWD. I can find info on slaughters of large numbers of deer with a small % testing postive in wild deer. I can also find examples of the slaughter of deer in breeding pens that were suspected of CWD and killed for that reason, but none of them ever tested postive for CWD. If CWD is being found in more than just deer then why stop at the slaughter of just deer in the pens or in the wild then? I would think every species of animal within that ranch or those counties should be slaughtered that might be a carrier at this point, correct?
Originally Posted By: La Longue Carabine
CWD is a slow and horrible death that takes years. Many (maybe most) that have it were killed by humans in an attempt to stop it from spreading.

So does CWD occur only in locations where all the animals that have it are killed or are you are saying that there are animals deaths from CWD 100% the time before the slaughter starts? If so can you provide links to clarify. Again sorry just a redneck so I need more detailed info at to this 100% mortality.
I consider any disease to humans, wildlife or livestock serious. This first case of WT with CWD is serious, but to me how it got to Central Texas is even more serious at this point. Since other animals stand the same chance of getting it just as this deer has until we find out how it got here. I do not always take what is written on any forum 100% truthful without asking questions.


First let me separate what I am certain of from what I am not certain of. I am NOT certain that 40 is the exact number of animal transfers from the infected site, since I did not hear this directly from the ranchers themselves. It was an estimation for a 3 year period given by someone who worked with TWIMS.

What I do know is that CWD and similar diseases in this class, are always fatal (Kreuzfeld-Jakob, and "Mad cow disease"). The exception may be Scrapie, and just today I came across some literature that said some sheep seem to show resistance. But whether they are simply able to delay the symptoms by a few years, or actually avoid infection is not known to me. If you want documentation that it is 100% fatal, follow this link:
https://tpwd.texas.gov/huntwild/wild/diseases/cwd/media/tpwd_cwd_factsheet.pdf

In regard to how many animals should be killed, that is still a contested issue because biologists are still determining how it is transmitted, and how likely each of those transmission methods are to infect other animals. They also don't know exactly how many other species can be affected by this prion. Right now, I believe the protocol is to kill and test cloven hooved ungulates that would have been in the same area that this infected deer was confined to. It is also important to remember that when it comes to testing, animals in the beginning stages of infection have a good chance of not registering positive on the test. CWD is slow to progress.
Killing all animals in a county would be quite extreme and would receive overwhelming resistance and backlash. There would have to be unfaltering scientific documentation proving it was necessary.

Regarding this question: "So does CWD occur only in locations where all the animals that have it are killed or are you are saying that there are animals deaths from CWD 100% the time before the slaughter starts?"
Understand that I said this:"CWD is a slow and horrible death that takes years. Many (maybe most) that have it were killed by humans in an attempt to stop it from spreading." Because someone else was saying that there had not been a large scale "die off" caused by CWD. So the point I was making was that many of the infected deer were killed before they had a chance to die from the disease. But earlier today I came across an article saying that in Colorado or Wyoming they were witnessing a 50% reduction from CWD in some wild Mule Deer herds. Again, it is slow, but unwavering.

How this particular deer contracted the disease is the million dollar question. Maybe some whitetail deer were brought to the ranch from outside the state illegally. Or, maybe they bought infected exotic deer from out of state (Whitetail cannot be imported from out of state, but exotics still can). Maybe from other livestock. Maybe even from deer attractant scent used on the property. A few days ago Virginia outlawed the use of urine based scent attractants, specifically because it can be a means of spreading CWD. This is the mess the epidemiologists have to deal with.

Last edited by La Longue Carabine; 07/06/15 06:23 AM.
Re: CWD in Texas [Re: La Longue Carabine] #5819544 07/06/15 04:20 PM
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Oh wow. Linking a tpwd "fact" sheet to support your arguments. Exactly what are tpwd "facts"on spikes today. confused2

Facts are facts though. Your statement that "there would have to be 'unfaltering' evidence before they tried to kill all deer in a county" is bogus since in Wisconsin they tried just that. Based on their flawed belief that it would have an impact.

As long as DNR's are listening to "Drs" like you, I guess they'll keep getting it wrong.

Again, DNR's have and will continue to kill vastly higher numbers than CWD has or will. Until the public rises up and tells them to go pound sand.


Crotchety old bastidge
Re: CWD in Texas [Re: hoof n wings] #5819627 07/06/15 05:06 PM
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Originally Posted By: hoof n wings
Then how did this one have it?
Originally Posted By: jmh004
Heck, there are scientist at A&M that say CWD may not even be transferable to other deer.



what about CWD infection rates on some of these game farms ???

CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) FarmUpdate DECEMBER 2011The CWD infection rate was nearly 80%, the highest ever in a North American captive herd. RECOMMENDATION: That the Board approve the purchase of 80acres of land for $465,000 for the Statewide Wildlife Habitat Program inPortage County and approve the restrictions on public use of the site.SUMMARY:

http://dnr.wi.gov/about/nrb/2011/december/12-11-2b2.pdf

For Immediate Release Thursday, October 2, 2014

Dustin Vande Hoef 515/281-3375 or 515/326-1616 (cell) or Dustin.VandeHoef@IowaAgriculture.gov

TEST RESULTS FROM CAPTIVE DEER HERD WITH CHRONIC WASTING DISEASE RELEASED 79.8 percent of the deer tested positive for the disease

DES MOINES – The Iowa Department of Agriculture and Land Stewardship today announced that the test results from the depopulation of a quarantined captive deer herd in north-central Iowa showed that 284 of the 356 deer, or 79.8% of the herd, tested positive for Chronic Wasting Disease (CWD). The owners of the quarantined herd have entered into a fence maintenance agreement with the Iowa Department of Agriculture and Land Stewardship,which requires the owners to maintain the 8’ foot perimeter fence around the herd premises for five years after the depopulation was complete and the premises had been cleaned and disinfected CWD is a progressive, fatal, degenerative neurological disease of farmed and free-ranging deer, elk, and moose. There is no known treatment or vaccine for CWD. CWD is not a disease that affects humans.On July 18, 2012, USDA Animal and Plant Health Inspection Service’s (APHIS)National Veterinary Services Lab in Ames, IA confirmed that a male whitetail deer harvested from a hunting preserve in southeast IA was positive for CWD. An investigation revealed that this animal had just been introduced into the hunting preserve from the above-referenced captive deer herd in north-central Iowa.The captive deer herd was immediately quarantined to prevent the spread of CWD. The herd has remained in quarantine until its depopulation on August 25 to 27, 2014.The Iowa Department of Agriculture and Land Stewardship participated in a joint operation to depopulate the infected herd with USDA Veterinary Services, which was the lead agency, and USDA Wildlife Services.Federal indemnity funding became available in 2014. USDA APHIS appraised the captive deer herd of 376 animals at that time, which was before depopulation and testing, at $1,354,250. At that time a herd plan was developed with the owners and officials from USDA and the Iowa Department of Agriculture and Land Stewardship.Once the depopulation was complete and the premises had been cleaned and disinfected, indemnity of $917,100.00 from the USDA has been or will be paid to the owners as compensation for the 356 captive deer depopulated.The Iowa Department of Agriculture and Land Stewardship operates a voluntary CWD program for farms that sell live animals. Currently 145 Iowa farms participate in the voluntary program. The above-referenced captive deer facility left the voluntary CWD program prior to the discovery of the disease as they had stopped selling live animals. All deer harvested in a hunting preserve must be tested for CWD. -30-

http://www.iowaagriculture.gov/press/2014press/press10022014.asp

*** see history of this CWD blunder here ;

http://www.iowadnr.gov/Portals/idnr/uploads/Hunting/070313_consent_order.pdf

On June 5, 2013, DNR conducted a fence inspection, after gaining approval from surrounding landowners, and confirmed that the fenced had beencut or removed in at least four separate locations; that the fence had degraded and was failing to maintain the enclosure around the Quarantined Premises in at least one area; that at least three gates had been opened;and that deer tracks were visible in and around one of the open areas in the sand on both sides of the fence, evidencing movement of deer into the Quarantined Premises.

http://www.iowadnr.gov/Portals/idnr/uploads/Hunting/060613_consent_order.pdf

Friday, December 14, 2012

DEFRA U.K. What is the risk of Chronic Wasting Disease CWD being introduced into Great Britain? A Qualitative Risk Assessment October 2012

snip...

In the USA, under the Food and Drug Administration’s BSE Feed Regulation (21 CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from deer and elk is prohibited for use in feed for ruminant animals. With regards to feed for non-ruminant animals, under FDA law, CWD positive deer may not be used for any animal feed or feed ingredients. For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law.

Animals considered at high risk for CWD include:

1) animals from areas declared to be endemic for CWD and/or to be CWD eradication zones and

2) deer and elk that at some time during the 60-month period prior to slaughter were in a captive herd that contained a CWD-positive animal.

Therefore, in the USA, materials from cervids other than CWD positive animals may be used in animal feed and feed ingredients for non-ruminants.

The amount of animal PAP that is of deer and/or elk origin imported from the USA to GB can not be determined, however, as it is not specified in TRACES. It may constitute a small percentage of the 8412 kilos of non-fish origin processed animal proteins that were imported from US into GB in 2011.

Overall, therefore, it is considered there is a __greater than negligible risk___ that (nonruminant) animal feed and pet food containing deer and/or elk protein is imported into GB.

There is uncertainty associated with this estimate given the lack of data on the amount of deer and/or elk protein possibly being imported in these products.

snip...

36% in 2007 (Almberg et al., 2011). In such areas, population declines of deer of up to 30 to 50% have been observed (Almberg et al., 2011). In areas of Colorado, the prevalence can be as high as 30% (EFSA, 2011). The clinical signs of CWD in affected adults are weight loss and behavioural changes that can span weeks or months (Williams, 2005). In addition, signs might include excessive salivation, behavioural alterations including a fixed stare and changes in interaction with other animals in the herd, and an altered stance (Williams, 2005). These signs are indistinguishable from cervids experimentally infected with bovine spongiform encephalopathy (BSE). Given this, if CWD was to be introduced into countries with BSE such as GB, for example, infected deer populations would need to be tested to differentiate if they were infected with CWD or BSE to minimise the risk of BSE entering the human food-chain via affected venison.

snip...

The rate of transmission of CWD has been reported to be as high as 30% and can approach 100% among captive animals in endemic areas (Safar et al., 2008).

snip...

In summary, in endemic areas, there is a medium probability that the soil and surrounding environment is contaminated with CWD prions and in a bioavailable form. In rural areas where CWD has not been reported and deer are present, there is a greater than negligible risk the soil is contaminated with CWD prion.

snip...

In summary, given the volume of tourists, hunters and servicemen moving between GB and North America, the probability of at least one person travelling to/from a CWD affected area and, in doing so, contaminating their clothing, footwear and/or equipment prior to arriving in GB is greater than negligible. For deer hunters, specifically, the risk is likely to be greater given the increased contact with deer and their environment. However, there is significant uncertainty associated with these estimates.

snip...

Therefore, it is considered that farmed and park deer may have a higher probability of exposure to CWD transferred to the environment than wild deer given the restricted habitat range and higher frequency of contact with tourists and returning GB residents.

snip...

http://webarchive.nationalarchives.gov.uk/20130822084033/http://www.defra.gov.uk/animal-diseases/files/qra_chronic-wasting-disease-121029.pdf

Friday, December 14, 2012

DEFRA U.K. What is the risk of Chronic Wasting Disease CWD being introduced into Great Britain? A Qualitative Risk Assessment October 2012

http://chronic-wasting-disease.blogspot.com/2012/12/defra-uk-what-is-risk-of-chronic.html

CHRONIC WASTING DISEASE CWD TSE PRION, how much does it pay to find CWD $$$

CWD, spreading it around...

for the game farm industry, and their constituents, to continue to believe that they are _NOT_, and or insinuate that they have _NEVER_ been part of the problem, will only continue to help spread cwd. the game farming industry, from the shooting pens, to the urine mills, the antler mills, the sperm mills, velvet mills, shooting pens, to large ranches, are not the only problem, but it is painfully obvious that they have been part of the problem for decades and decades, just spreading it around, as with transportation and or exportation and or importation of cervids from game farming industry, and have been proven to spread cwd. no one need to look any further than South Korea blunder ;

===========================================

spreading cwd around...

Between 1996 and 2002, chronic wasting disease was diagnosed in 39 herds of farmed elk in Saskatchewan in a single epidemic. All of these herds were depopulated as part of the Canadian Food Inspection Agency’s (CFIA) disease eradication program. Animals, primarily over 12 mo of age, were tested for the presence CWD prions following euthanasia. Twenty-one of the herds were linked through movements of live animals with latent CWD from a single infected source herd in Saskatchewan, 17 through movements of animals from 7 of the secondarily infected herds.

***The source herd is believed to have become infected via importation of animals from a game farm in South Dakota where CWD was subsequently diagnosed (7,4). A wide range in herd prevalence of CWD at the time of herd depopulation of these herds was observed. Within-herd transmission was observed on some farms, while the disease remained confined to the introduced animals on other farms.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2081988/

spreading cwd around...

Friday, May 13, 2011

Chronic Wasting Disease (CWD) outbreaks and surveillance program in the Republic of Korea

Chronic Wasting Disease (CWD) outbreaks and surveillance program in the Republic of Korea

Hyun-Joo Sohn, Yoon-Hee Lee, Min-jeong Kim, Eun-Im Yun, Hyo-Jin Kim, Won-Yong Lee, Dong-Seob Tark, In- Soo Cho, Foreign Animal Disease Research Division, National Veterinary Research and Quarantine Service, Republic of Korea

Chronic wasting disease (CWD) has been recognized as an important prion disease in native North America deer and Rocky mountain elks. The disease is a unique member of the transmissible spongiform encephalopathies (TSEs), which naturally affects only a few species. CWD had been limited to USA and Canada until 2000.

On 28 December 2000, information from the Canadian government showed that a total of 95 elk had been exported from farms with CWD to Korea. These consisted of 23 elk in 1994 originating from the so-called “source farm” in Canada, and 72 elk in 1997, which had been held in pre export quarantine at the “source farm”.Based on export information of CWD suspected elk from Canada to Korea, CWD surveillance program was initiated by the Ministry of Agriculture and Forestry (MAF) in 2001.

All elks imported in 1997 were traced back, however elks imported in 1994 were impossible to identify. CWD control measures included stamping out of all animals in the affected farm, and thorough cleaning and disinfection of the premises. In addition, nationwide clinical surveillance of Korean native cervids, and improved measures to ensure reporting of CWD suspect cases were implemented.

Total of 9 elks were found to be affected. CWD was designated as a notifiable disease under the Act for Prevention of Livestock Epidemics in 2002.

Additional CWD cases - 12 elks and 2 elks - were diagnosed in 2004 and 2005.

Since February of 2005, when slaughtered elks were found to be positive, all slaughtered cervid for human consumption at abattoirs were designated as target of the CWD surveillance program. Currently, CWD laboratory testing is only conducted by National Reference Laboratory on CWD, which is the Foreign Animal Disease Division (FADD) of National Veterinary Research and Quarantine Service (NVRQS).

In July 2010, one out of 3 elks from Farm 1 which were slaughtered for the human consumption was confirmed as positive. Consequently, all cervid – 54 elks, 41 Sika deer and 5 Albino deer – were culled and one elk was found to be positive. Epidemiological investigations were conducted by Veterinary Epidemiology Division (VED) of NVRQS in collaboration with provincial veterinary services.

Epidemiologically related farms were found as 3 farms and all cervid at these farms were culled and subjected to CWD diagnosis. Three elks and 5 crossbreeds (Red deer and Sika deer) were confirmed as positive at farm 2.

All cervids at Farm 3 and Farm 4 – 15 elks and 47 elks – were culled and confirmed as negative.

Further epidemiological investigations showed that these CWD outbreaks were linked to the importation of elks from Canada in 1994 based on circumstantial evidences.

In December 2010, one elk was confirmed as positive at Farm 5. Consequently, all cervid – 3 elks, 11 Manchurian Sika deer and 20 Sika deer – were culled and one Manchurian Sika deer and seven Sika deer were found to be positive. This is the first report of CWD in these sub-species of deer. Epidemiological investigations found that the owner of the Farm 2 in CWD outbreaks in July 2010 had co-owned the Farm 5.

In addition, it was newly revealed that one positive elk was introduced from Farm 6 of Jinju-si Gyeongsang Namdo. All cervid – 19 elks, 15 crossbreed (species unknown) and 64 Sika deer – of Farm 6 were culled, but all confirmed as negative.

http://www.prion2011.ca/files/2011TSEBookletV6Final.pdf

http://www.prion2011.ca/files/PRION_2011_-_Posters_(May_5-11).pdf

http://www.cwd-info.org/index.php/fuseaction/news.detail/ID/c792d0e56e0cb3ee3a6517e754729cac

http://chronic-wasting-disease.blogspot.com/2011/05/chronic-wasting-disease-cwd-outbreaks.html


Terry S. Singeltary Sr.

Re: CWD in Texas [Re: therancher] #5820039 07/06/15 08:39 PM
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Originally Posted By: therancher
Oh wow. Linking a tpwd "fact" sheet to support your arguments. Exactly what are tpwd "facts"on spikes today. confused2

Facts are facts though. Your statement that "there would have to be 'unfaltering' evidence before they tried to kill all deer in a county" is bogus since in Wisconsin they tried just that. Based on their flawed belief that it would have an impact.

As long as DNR's are listening to "Drs" like you, I guess they'll keep getting it wrong.

Again, DNR's have and will continue to kill vastly higher numbers than CWD has or will. Until the public rises up and tells them to go pound sand.


Still ignorantly criticizing I see.
One deer in Texas vs a population of infected deer in Wisconsin is not the same situation. Likewise, scientists did not know then what we know now.

Re: CWD in Texas [Re: Frio County Hunts] #5820165 07/06/15 10:26 PM
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First a doctor, now a scientist. Impressive.

Re: CWD in Texas [Re: Frio County Hunts] #5820171 07/06/15 10:28 PM
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I do like how flounder cited all his information. Those were some interesting reads for sure.

Re: CWD in Texas [Re: La Longue Carabine] #5820192 07/06/15 10:42 PM
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Originally Posted By: La Longue Carabine
Originally Posted By: therancher
Oh wow. Linking a tpwd "fact" sheet to support your arguments. Exactly what are tpwd "facts"on spikes today. confused2

Facts are facts though. Your statement that "there would have to be 'unfaltering' evidence before they tried to kill all deer in a county" is bogus since in Wisconsin they tried just that. Based on their flawed belief that it would have an impact.

As long as DNR's are listening to "Drs" like you, I guess they'll keep getting it wrong.

Again, DNR's have and will continue to kill vastly higher numbers than CWD has or will. Until the public rises up and tells them to go pound sand.


Still ignorantly criticizing I see.
One deer in Texas vs a population of infected deer in Wisconsin is not the same situation. Likewise, scientists did not know then what we know now.


I would question any scientist or doctor on what they know now, and that's reading this latest prion gathering post. They are still grasping at straws to say the least.

And let me state clearly I have no skins in the ranching or breeding game. I think at this point it would be fair to say everyone with a theory or opinion is ignorant to truly understanding this disease and what causes it. And that's why you don't just kill healthy acting deer on a wide spread scale until your understand more of what you dealing with. Especially basing their lives on a test that could be extremely flawed to begin with.

This could be genetic as well as environmental just like many researchers believe Alzheimers is. And logically when you see a high occurance of positive tests on deer farms would logically make sense of a genetic trait that the test identifies.

There is not enough factually supported data to be calling anybody ignorant except the supposed experts record of treating this problem that they claim to understand more than we do.

Last edited by Pitchfork Predator; 07/06/15 10:45 PM.

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Re: CWD in Texas [Re: Pitchfork Predator] #5820779 07/07/15 04:31 AM
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Originally Posted By: Pitchfork Predator
Originally Posted By: La Longue Carabine
Originally Posted By: therancher
Oh wow. Linking a tpwd "fact" sheet to support your arguments. Exactly what are tpwd "facts"on spikes today. confused2

Facts are facts though. Your statement that "there would have to be 'unfaltering' evidence before they tried to kill all deer in a county" is bogus since in Wisconsin they tried just that. Based on their flawed belief that it would have an impact.

As long as DNR's are listening to "Drs" like you, I guess they'll keep getting it wrong.

Again, DNR's have and will continue to kill vastly higher numbers than CWD has or will. Until the public rises up and tells them to go pound sand.


Still ignorantly criticizing I see.
One deer in Texas vs a population of infected deer in Wisconsin is not the same situation. Likewise, scientists did not know then what we know now.


I would question any scientist or doctor on what they know now, and that's reading this latest prion gathering post. They are still grasping at straws to say the least.

And let me state clearly I have no skins in the ranching or breeding game. I think at this point it would be fair to say everyone with a theory or opinion is ignorant to truly understanding this disease and what causes it. And that's why you don't just kill healthy acting deer on a wide spread scale until your understand more of what you dealing with. Especially basing their lives on a test that could be extremely flawed to begin with.

This could be genetic as well as environmental just like many researchers believe Alzheimers is. And logically when you see a high occurance of positive tests on deer farms would logically make sense of a genetic trait that the test identifies.

There is not enough factually supported data to be calling anybody ignorant except the supposed experts record of treating this problem that they claim to understand more than we do.


Couldn't agree more. Jumping to conclusions with incomplete data is no platform to be calling people ignorant from.

I'll note he didn't explain how the "correct data" has had "biologists" changing their stories for decades.

Last edited by therancher; 07/07/15 04:32 AM.

Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5820982 07/07/15 01:20 PM
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I'm sure as a doctor, and a scientist, he will set it all straight before long.

Re: CWD in Texas [Re: Frio County Hunts] #5820994 07/07/15 01:32 PM
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The Ranch with the CWD Case offered to donate all of the deer to the A&M Research team where animals are sent for testing. That way they would be able to see if rectal and blood testing could be used in accordance with testing with the brain stem and TPWD refused. The unknown is what is somewhat scary about CWD and TPWD and TAHC should be working with the owners and take advantage of the situation to learn more about CWD and help them get through this for everyone's benefit. Instead, TPWD is treating them like criminals and only seem to care about destroying the herd (EVIDENCE) and any linkage to it, that's what's more criminal in my opinion!

Re: CWD in Texas [Re: Frio County Hunts] #5821012 07/07/15 01:48 PM
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I'm willing to bet all these breeders in Texas, most of whom are probably some of the wealthiest people in Texas, aren't going to take this lying down. I bet before too long we will be talking about TPWD getting sued over this.

Re: CWD in Texas [Re: Bowman24] #5821080 07/07/15 02:34 PM
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Originally Posted By: Bowman24
The Ranch with the CWD Case offered to donate all of the deer to the A&M Research team where animals are sent for testing. That way they would be able to see if rectal and blood testing could be used in accordance with testing with the brain stem and TPWD refused. The unknown is what is somewhat scary about CWD and TPWD and TAHC should be working with the owners and take advantage of the situation to learn more about CWD and help them get through this for everyone's benefit. Instead, TPWD is treating them like criminals and only seem to care about destroying the herd (EVIDENCE) and any linkage to it, that's what's more criminal in my opinion!

This has been an on going problem, no live test has been validated, yet they destroy herds whithout letting researchers take samples that could possibly lead to a live test.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: Frio County Hunts] #5821336 07/07/15 05:50 PM
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TPWD is tracking all deer movement into, and out of that ranch in Medina County for the last 5 years. That will pretty much connect every breeder in Texas to this deer in some way. So instead of testing a couple hundred animals on one ranch, they will be able to claim who knows how many animals on who knows how many ranches to test. The breeding industry is about to get hammered.
I don't own a breeding facility, or even work on one is these ranches. I sure will hate to see how many deer are going to be killed in the name of "containment" in the coming months. I'm sure only a few of the most profitable breeders will be the only ones left after all this.
I blame these HF ranches and breeders for a lot of things in today's hunting world. The prices for leases, and basically the price of hunting in general has gone through the roof in recent years in part, what I believe, to these whitetail ranches. That being said, I hate to see the government come in and tell people what to do with their private property. The next few weeks will be very interesting in how the state will handle all this

Re: CWD in Texas [Re: Frio County Hunts] #5821378 07/07/15 06:27 PM
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The wealthiest hunters I know (the kind that can afford to hunt places where legitimate Boone and Crockett caliber deer can be harvested) find the practice of shooting pen raised deer detestable.

Last edited by JMalin; 07/07/15 06:29 PM.
Re: CWD in Texas [Re: Frio County Hunts] #5821454 07/07/15 07:00 PM
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I'm not saying shooting pen raised deer is my thing. But a person ought to be able to decide what to do on their own land don't you think?

Re: CWD in Texas [Re: JMalin] #5821466 07/07/15 07:07 PM
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Originally Posted By: JMalin
The wealthiest hunters I know (the kind that can afford to hunt places where legitimate Boone and Crockett caliber deer can be harvested) find the practice of shooting pen raised deer detestable.


Cool but that's not what the thread is about.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Bowman24] #5821488 07/07/15 07:21 PM
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Originally Posted By: Bowman24
The Ranch with the CWD Case offered to donate all of the deer to the A&M Research team where animals are sent for testing. That way they would be able to see if rectal and blood testing could be used in accordance with testing with the brain stem and TPWD refused. The unknown is what is somewhat scary about CWD and TPWD and TAHC should be working with the owners and take advantage of the situation to learn more about CWD and help them get through this for everyone's benefit. Instead, TPWD is treating them like criminals and only seem to care about destroying the herd (EVIDENCE) and any linkage to it, that's what's more criminal in my opinion!



for what's it's worth, I will ggive the owners a thumbs up up for ;


>>>The Ranch with the CWD Case offered to donate all of the deer to the A&M Research team where animals are sent for testing. That way they would be able to see if rectal and blood testing could be used in accordance with testing with the brain stem<<<


but not knowing the rest of the story, I won't comment about TPWD or TAHC and any reasoning they might have for not wanting use the herd for research confused2

I do hope they test all of the deer for cwd, and the results are published to the public?

however, I will say this. I know of another situation with captives with cwd, that if I am not mistaken, after cwd was discovered, there was a time period where the situation was set into limbo, either for litigations, courts, the government, the owners, whatever, those perfectly healthy deer that everyone was so concerned about, all those healthy looking deer, after the final testing was done after much delay, a long time after, there was an 79.8% CWD infection rate documented. I'm just saying, you let this cwd linger, the chances of the cwd agent spreading grows and grows. so dammed if they do, danged if they don't. all I am saying, if you snooze, you loose. this is why ;


For Immediate Release Thursday, October 2, 2014

Dustin Vande Hoef 515/281-3375 or 515/326-1616 (cell) or Dustin.VandeHoef@IowaAgriculture.gov

TEST RESULTS FROM CAPTIVE DEER HERD WITH CHRONIC WASTING DISEASE RELEASED 79.8 percent of the deer tested positive for the disease

DES MOINES – The Iowa Department of Agriculture and Land Stewardship today announced that the test results from the depopulation of a quarantined captive deer herd in north-central Iowa showed that 284 of the 356 deer, or 79.8% of the herd, tested positive for Chronic Wasting Disease (CWD).

http://www.iowaagriculture.gov/press/2014press/press10022014.asp

*** see history of this CWD blunder here ;

http://www.iowadnr.gov/Portals/idnr/uploads/Hunting/070313_consent_order.pdf

On June 5, 2013, DNR conducted a fence inspection, after gaining approval from surrounding landowners, and confirmed that the fenced had been cut or removed in at least four separate locations; that the fence had degraded and was failing to maintain the enclosure around the Quarantined Premises in at least one area; that at least three gates had been opened;and that deer tracks were visible in and around one of the open areas in the sand on both sides of the fence, evidencing movement of deer into the Quarantined Premises.

http://www.iowadnr.gov/Portals/idnr/uploads/Hunting/060613_consent_order.pdf



***Recently, we have been using PMCA to study the role of environmental prion contamination on the horizontal spreading of TSEs. These experiments have focused on the study of the interaction of prions with plants and environmentally relevant surfaces. Our results show that plants (both leaves and roots) bind tightly to prions present in brain extracts and excreta (urine and feces) and retain even small quantities of PrPSc for long periods of time. Strikingly, ingestion of prioncontaminated leaves and roots produced disease with a 100% attack rate and an incubation period not substantially longer than feeding animals directly with scrapie brain homogenate. Furthermore, plants can uptake prions from contaminated soil and transport them to different parts of the plant tissue (stem and leaves). Similarly, prions bind tightly to a variety of environmentallyrelevant surfaces, including stones, wood, metals, plastic, glass, cement, etc. Prion contaminated surfaces efficiently transmit prion disease when these materials were directly injected into the brain of animals and strikingly when the contaminated surfaces were just placed in the animal cage. These findings demonstrate that environmental materials can efficiently bind infectious prions and act as carriers of infectivity, suggesting that they may play an important role in the horizontal transmission of the disease.

Since its invention 13 years ago, PMCA has helped to answer fundamental questions of prion propagation and has broad applications in research areas including the food industry, blood bank safety and human and veterinary disease diagnosis.

https://prion2015.files.wordpress.com/2015/05/programguide1.pdf

Wednesday, June 10, 2015

Zoonotic Potential of CWD Prions

LATE-BREAKING ABSTRACTS

http://chronic-wasting-disease.blogspot.com/2015/06/zoonotic-potential-of-cwd-prions.html

Wednesday, April 22, 2015

Circulation of prions within dust on a scrapie affected farm

http://transmissiblespongiformencephalop...in-dust-on.html

Friday, January 30, 2015

*** Scrapie: a particularly persistent pathogen ***

http://transmissiblespongiformencephalop...t-pathogen.html

2012

PO-039: A comparison of scrapie and chronic wasting disease in white-tailed deer

Justin Greenlee, Jodi Smith, Eric Nicholson US Dept. Agriculture; Agricultural Research Service, National Animal Disease Center; Ames, IA USA

snip...

The results of this study suggest that there are many similarities in the manifestation of CWD and scrapie in WTD after IC inoculation including early and widespread presence of PrPSc in lymphoid tissues, clinical signs of depression and weight loss progressing to wasting, and an incubation time of 21-23 months. Moreover, western blots (WB) done on brain material from the obex region have a molecular profile similar to CWD and distinct from tissues of the cerebrum or the scrapie inoculum. However, results of microscopic and IHC examination indicate that there are differences between the lesions expected in CWD and those that occur in deer with scrapie: amyloid plaques were not noted in any sections of brain examined from these deer and the pattern of immunoreactivity by IHC was diffuse rather than plaque-like.

*** After a natural route of exposure, 100% of WTD were susceptible to scrapie.

Deer developed clinical signs of wasting and mental depression and were necropsied from 28 to 33 months PI. Tissues from these deer were positive for PrPSc by IHC and WB. Similar to IC inoculated deer, samples from these deer exhibited two different molecular profiles: samples from obex resembled CWD whereas those from cerebrum were similar to the original scrapie inoculum. On further examination by WB using a panel of antibodies, the tissues from deer with scrapie exhibit properties differing from tissues either from sheep with scrapie or WTD with CWD. Samples from WTD with CWD or sheep with scrapie are strongly immunoreactive when probed with mAb P4, however, samples from WTD with scrapie are only weakly immunoreactive. In contrast, when probed with mAb’s 6H4 or SAF 84, samples from sheep with scrapie and WTD with CWD are weakly immunoreactive and samples from WTD with scrapie are strongly positive. This work demonstrates that WTD are highly susceptible to sheep scrapie, but on first passage, scrapie in WTD is differentiable from CWD.

http://www.landesbioscience.com/journals/prion/03-Prion6-2-Transmission-and-strains.pdf

2011

*** After a natural route of exposure, 100% of white-tailed deer were susceptible to scrapie.

http://www.usaha.org/Portals/6/Reports/2011/report-cwal-2011.pdf

*** We conclude that TSE infectivity is likely to survive burial for long time periods with minimal loss of infectivity and limited movement from the original burial site. However PMCA results have shown that there is the potential for rainwater to elute TSE related material from soil which could lead to the contamination of a wider area. These experiments reinforce the importance of risk assessment when disposing of TSE risk materials.

*** The results show that even highly diluted PrPSc can bind efficiently to polypropylene, stainless steel, glass, wood and stone and propagate the conversion of normal prion protein. For in vivo experiments, hamsters were ic injected with implants incubated in 1% 263K-infected brain homogenate. Hamsters, inoculated with 263K-contaminated implants of all groups, developed typical signs of prion disease, whereas control animals inoculated with non-contaminated materials did not.

PRION 2014 CONFERENCE

CHRONIC WASTING DISEASE CWD

A FEW FINDINGS ;

Conclusions. To our knowledge, this is the first established experimental model of CWD in TgSB3985. We found evidence for co-existence or divergence of two CWD strains adapted to Tga20 mice and their replication in TgSB3985 mice. Finally, we observed phenotypic differences between cervid-derived CWD and CWD/Tg20 strains upon propagation in TgSB3985 mice. Further studies are underway to characterize these strains.

We conclude that TSE infectivity is likely to survive burial for long time periods with minimal loss of infectivity and limited movement from the original burial site. However PMCA results have shown that there is the potential for rainwater to elute TSE related material from soil which could lead to the contamination of a wider area. These experiments reinforce the importance of risk assessment when disposing of TSE risk materials.

The results show that even highly diluted PrPSc can bind efficiently to polypropylene, stainless steel, glass, wood and stone and propagate the conversion of normal prion protein. For in vivo experiments, hamsters were ic injected with implants incubated in 1% 263K-infected brain homogenate. Hamsters, inoculated with 263K-contaminated implants of all groups, developed typical signs of prion disease, whereas control animals inoculated with non-contaminated materials did not.

Our data establish that meadow voles are permissive to CWD via peripheral exposure route, suggesting they could serve as an environmental reservoir for CWD. Additionally, our data are consistent with the hypothesis that at least two strains of CWD circulate in naturally-infected cervid populations and provide evidence that meadow voles are a useful tool for CWD strain typing.

Conclusion. CWD prions are shed in saliva and urine of infected deer as early as 3 months post infection and throughout the subsequent >1.5 year course of infection. In current work we are examining the relationship of prionemia to excretion and the impact of excreted prion binding to surfaces and particulates in the environment.

Conclusion. CWD prions (as inferred by prion seeding activity by RT-QuIC) are shed in urine of infected deer as early as 6 months post inoculation and throughout the subsequent disease course. Further studies are in progress refining the real-time urinary prion assay sensitivity and we are examining more closely the excretion time frame, magnitude, and sample variables in relationship to inoculation route and prionemia in naturally and experimentally CWD-infected cervids.

Conclusions. Our results suggested that the odds of infection for CWD is likely controlled by areas that congregate deer thus increasing direct transmission (deer-to-deer interactions) or indirect transmission (deer-to-environment) by sharing or depositing infectious prion proteins in these preferred habitats. Epidemiology of CWD in the eastern U.S. is likely controlled by separate factors than found in the Midwestern and endemic areas for CWD and can assist in performing more efficient surveillance efforts for the region.

Conclusions. During the pre-symptomatic stage of CWD infection and throughout the course of disease deer may be shedding multiple LD50 doses per day in their saliva. CWD prion shedding through saliva and excreta may account for the unprecedented spread of this prion disease in nature.

see full text and more ;

Monday, June 23, 2014

*** PRION 2014 CONFERENCE CHRONIC WASTING DISEASE CWD

https://www.landesbioscience.com/journal...n%20Animals.pdf

http://chronic-wasting-disease.blogspot.com/2014/06/prion-2014-chronic-wasting-disease-cwd.html

*** Infectious agent of sheep scrapie may persist in the environment for at least 16 years***

Gudmundur Georgsson1, Sigurdur Sigurdarson2 and Paul Brown3

http://jgv.sgmjournals.org/content/87/12/3737.full

New studies on the heat resistance of hamster-adapted scrapie agent: Threshold survival after ashing at 600°C suggests an inorganic template of replication

http://www.pnas.org/content/97/7/3418.full

Prion Infected Meat-and-Bone Meal Is Still Infectious after Biodiesel Production

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493038/

Detection of protease-resistant cervid prion protein in water from a CWD-endemic area

http://www.landesbioscience.com/journals/prion/NicholsPRION3-3.pdf

A Quantitative Assessment of the Amount of Prion Diverted to Category 1 Materials and Wastewater During Processing

http://onlinelibrary.wiley.com/doi/10.1111/j.1539-6924.2012.01922.x/abstract

Rapid assessment of bovine spongiform encephalopathy prion inactivation by heat treatment in yellow grease produced in the industrial manufacturing process of meat and bone meals

http://transmissiblespongiformencephalop...spongiform.html

98 | Veterinary Record | January 24, 2015

EDITORIAL

Scrapie: a particularly persistent pathogen

Cristina Acín

Resistant prions in the environment have been the sword of Damocles for scrapie control and eradication. Attempts to establish which physical and chemical agents could be applied to inactivate or moderate scrapie infectivity were initiated in the 1960s and 1970s,with the first study of this type focusing on the effect of heat treatment in reducing prion infectivity (Hunter and Millson 1964). Nowadays, most of the chemical procedures that aim to inactivate the prion protein are based on the method developed by Kimberlin and collaborators (1983). This procedure consists of treatment with 20,000 parts per million free chlorine solution, for a minimum of one hour, of all surfaces that need to be sterilised (in laboratories, lambing pens, slaughterhouses, and so on). Despite this, veterinarians and farmers may still ask a range of questions, such as ‘Is there an official procedure published somewhere?’ and ‘Is there an international organisation which recommends and defines the exact method of scrapie decontamination that must be applied?’

From a European perspective, it is difficult to find a treatment that could be applied, especially in relation to the disinfection of surfaces in lambing pens of affected flocks. A 999/2001 EU regulation on controlling spongiform encephalopathies (European Parliament and Council 2001) did not specify a particular decontamination measure to be used when an outbreak of scrapie is diagnosed. There is only a brief recommendation in Annex VII concerning the control and eradication of transmissible spongiform encephalopathies (TSE s).

Chapter B of the regulation explains the measures that must be applied if new caprine animals are to be introduced to a holding where a scrapie outbreak has previously been diagnosed. In that case, the statement indicates that caprine animals can be introduced ‘provided that a cleaning and disinfection of all animal housing on the premises has been carried out following destocking’.

Issues around cleaning and disinfection are common in prion prevention recommendations, but relevant authorities, veterinarians and farmers may have difficulties in finding the specific protocol which applies. The European Food and Safety Authority (EFSA ) published a detailed report about the efficacy of certain biocides, such as sodium hydroxide, sodium hypochlorite, guanidine and even a formulation of copper or iron metal ions in combination with hydrogen peroxide, against prions (EFSA 2009). The report was based on scientific evidence (Fichet and others 2004, Lemmer and others 2004, Gao and others 2006, Solassol and others 2006) but unfortunately the decontamination measures were not assessed under outbreak conditions.

The EFSA Panel on Biological Hazards recently published its conclusions on the scrapie situation in the EU after 10 years of monitoring and control of the disease in sheep and goats (EFSA 2014), and one of the most interesting findings was the Icelandic experience regarding the effect of disinfection in scrapie control. The Icelandic plan consisted of: culling scrapie-affected sheep or the whole flock in newly diagnosed outbreaks; deep cleaning and disinfection of stables, sheds, barns and equipment with high pressure washing followed by cleaning with 500 parts per million of hypochlorite; drying and treatment with 300 ppm of iodophor; and restocking was not permitted for at least two years. Even when all of these measures were implemented, scrapie recurred on several farms, indicating that the infectious agent survived for years in the environment, even as many as 16 years after restocking (Georgsson and others 2006).

In the rest of the countries considered in the EFSA (2014) report, recommendations for disinfection measures were not specifically defined at the government level. In the report, the only recommendation that is made for sheep is repopulation with sheep with scrapie-resistant genotypes. This reduces the risk of scrapie recurrence but it is difficult to know its effect on the infection.

Until the EFSA was established (in May 2003), scientific opinions about TSE s were provided by the Scientific Steering Committee (SSC) of the EC, whose advice regarding inactivation procedures focused on treating animal waste at high temperatures (150°C for three hours) and high pressure alkaline hydrolysis (SSC 2003). At the same time, the TSE Risk Management Subgroup of the Advisory Committee on Dangerous Pathogens (ACDP) in the UK published guidance on safe working and the prevention of TSE infection. Annex C of the ACDP report established that sodium hypochlorite was considered to be effective, but only if 20,000 ppm of available chlorine was present for at least one hour, which has practical limitations such as the release of chlorine gas, corrosion, incompatibility with formaldehyde, alcohols and acids, rapid inactivation of its active chemicals and the stability of dilutions (ACDP 2009).

In an international context, the World Organisation for Animal Health (OIE) does not recommend a specific disinfection protocol for prion agents in its Terrestrial Code or Manual. Chapter 4.13 of the Terrestrial Code, General recommendations on disinfection and disinsection (OIE 2014), focuses on foot-and-mouth disease virus, mycobacteria and Bacillus anthracis, but not on prion disinfection. Nevertheless, the last update published by the OIE on bovine spongiform encephalopathy (OIE 2012) indicates that few effective decontamination techniques are available to inactivate the agent on surfaces, and recommends the removal of all organic material and the use of sodium hydroxide, or a sodium hypochlorite solution containing 2 per cent available chlorine, for more than one hour at 20ºC.

The World Health Organization outlines guidelines for the control of TSE s, and also emphasises the importance of mechanically cleaning surfaces before disinfection with sodium hydroxide or sodium hypochlorite for one hour (WHO 1999).

Finally, the relevant agencies in both Canada and the USA suggest that the best treatments for surfaces potentially contaminated with prions are sodium hydroxide or sodium hypochlorite at 20,000 ppm. This is a 2 per cent solution, while most commercial household bleaches contain 5.25 per cent sodium hypochlorite. It is therefore recommended to dilute one part 5.25 per cent bleach with 1.5 parts water (CDC 2009, Canadian Food Inspection Agency 2013).

So what should we do about disinfection against prions? First, it is suggested that a single protocol be created by international authorities to homogenise inactivation procedures and enable their application in all scrapie-affected countries. Sodium hypochlorite with 20,000 ppm of available chlorine seems to be the procedure used in most countries, as noted in a paper summarised on p 99 of this issue of Veterinary Record (Hawkins and others 2015). But are we totally sure of its effectiveness as a preventive measure in a scrapie outbreak? Would an in-depth study of the recurrence of scrapie disease be needed?

What we can conclude is that, if we want to fight prion diseases, and specifically classical scrapie, we must focus on the accuracy of diagnosis, monitoring and surveillance; appropriate animal identification and control of movements; and, in the end, have homogeneous and suitable protocols to decontaminate and disinfect lambing barns, sheds and equipment available to veterinarians and farmers. Finally, further investigations into the resistance of prion proteins in the diversity of environmental surfaces are required.

References

snip...

98 | Veterinary Record | January 24, 2015

http://veterinaryrecord.bmj.com/content/176/4/97.extract

Persistence of ovine scrapie infectivity in a farm environment following cleaning and decontamination

Steve A. C. Hawkins, MIBiol, Pathology Department1, Hugh A. Simmons, BVSc MRCVS, MBA, MA Animal Services Unit1, Kevin C. Gough, BSc, PhD2 and Ben C. Maddison, BSc, PhD3 + Author Affiliations

1Animal and Plant Health Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK 2School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington, Loughborough, Leicestershire LE12 5RD, UK 3ADAS UK, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington, Loughborough, Leicestershire LE12 5RD, UK E-mail for correspondence: ben.maddison@adas.co.uk Abstract Scrapie of sheep/goats and chronic wasting disease of deer/elk are contagious prion diseases where environmental reservoirs are directly implicated in the transmission of disease. In this study, the effectiveness of recommended scrapie farm decontamination regimens was evaluated by a sheep bioassay using buildings naturally contaminated with scrapie. Pens within a farm building were treated with either 20,000 parts per million free chorine solution for one hour or were treated with the same but were followed by painting and full re-galvanisation or replacement of metalwork within the pen. Scrapie susceptible lambs of the PRNP genotype VRQ/VRQ were reared within these pens and their scrapie status was monitored by recto-anal mucosa-associated lymphoid tissue. All animals became infected over an 18-month period, even in the pen that had been subject to the most stringent decontamination process. These data suggest that recommended current guidelines for the decontamination of farm buildings following outbreaks of scrapie do little to reduce the titre of infectious scrapie material and that environmental recontamination could also be an issue associated with these premises.

SNIP...

Discussion

Thorough pressure washing of a pen had no effect on the amount of bioavailable scrapie infectivity (pen B). The routine removal of prions from surfaces within a laboratory setting is treatment for a minimum of one hour with 20,000 ppm free chlorine, a method originally based on the use of brain macerates from infected rodents to evaluate the effectiveness of decontamination (Kimberlin and others 1983). Further studies have also investigated the effectiveness of hypochlorite disinfection of metal surfaces to simulate the decontamination of surgical devices within a hospital setting. Such treatments with hypochlorite solution were able to reduce infectivity by 5.5 logs to lower than the sensitivity of the bioassay used (Lemmer and others 2004). Analogous treatment of the pen surfaces did not effectively remove the levels of scrapie infectivity over that of the control pens, indicating that this method of decontamination is not effective within a farm setting. This may be due to the high level of biological matrix that is present upon surfaces within the farm environment, which may reduce the amount of free chlorine available to inactivate any infectious prion. Remarkably 1/5 sheep introduced into pen D had also became scrapie positive within nine months, with all animals in this pen being RAMALT positive by 18 months of age. Pen D was no further away from the control pen (pen A) than any of the other pens within this barn. Localised hot spots of infectivity may be present within scrapie-contaminated environments, but it is unlikely that pen D area had an amount of scrapie contamination that was significantly different than the other areas within this building. Similarly, there were no differences in how the biosecurity of pen D was maintained, or how this pen was ventilated compared with the other pens. This observation, perhaps, indicates the slower kinetics of disease uptake within this pen and is consistent with a more thorough prion removal and recontamination. These observations may also account for the presence of inadvertent scrapie cases within other studies, where despite stringent biosecurity, control animals have become scrapie positive during challenge studies using barns that also housed scrapie-affected animals (Ryder and others 2009). The bioassay data indicate that the exposure of the sheep to a farm environment after decontamination efforts thought to be effective in removing scrapie is sufficient for the animals to become infected with scrapie. The main exposure routes within this scenario are likely to be via the oral route, during feeding and drinking, and respiratory and conjunctival routes. It has been demonstrated that scrapie infectivity can be efficiently transmitted via the nasal route in sheep (Hamir and others 2008), as is the case for CWD in both murine models and in white-tailed deer (Denkers and others 2010, 2013). Recently, it has also been demonstrated that CWD prions presented as dust when bound to the soil mineral montmorillonite can be infectious via the nasal route (Nichols and others 2013). When considering pens C and D, the actual source of the infectious agent in the pens is not known, it is possible that biologically relevant levels of prion survive on surfaces during the decontamination regimen (pen C). With the use of galvanising and painting (pen D) covering and sealing the surface of the pen, it is possible that scrapie material recontaminated the pens by the movement of infectious prions contained within dusts originating from other parts of the barn that were not decontaminated or from other areas of the farm.

Given that scrapie prions are widespread on the surfaces of affected farms (Maddison and others 2010a), irrespective of the source of the infectious prions in the pens, this study clearly highlights the difficulties that are faced with the effective removal of environmentally associated scrapie infectivity. This is likely to be paralleled in CWD which shows strong similarities to scrapie in terms of both the dissemination of prions into the environment and the facile mode of disease transmission. These data further contribute to the understanding that prion diseases can be highly transmissible between susceptible individuals not just by direct contact but through highly stable environmental reservoirs that are refractory to decontamination.

The presence of these environmentally associated prions in farm buildings make the control of these diseases a considerable challenge, especially in animal species such as goats where there is lack of genetic resistance to scrapie and, therefore, no scope to re-stock farms with animals that are resistant to scrapie.

Scrapie Sheep Goats Transmissible spongiform encephalopathies (TSE) Accepted October 12, 2014. Published Online First 31 October 2014

http://veterinaryrecord.bmj.com/content/early/2014/10/31/vr.102743.abstract

Monday, November 3, 2014

Persistence of ovine scrapie infectivity in a farm environment following cleaning and decontamination

http://transmissiblespongiformencephalopathy.blogspot.com/2014/11/persistence-of-ovine-scrapie.html

PPo3-22:

Detection of Environmentally Associated PrPSc on a Farm with Endemic Scrapie

Ben C. Maddison,1 Claire A. Baker,1 Helen C. Rees,1 Linda A. Terry,2 Leigh Thorne,2 Susan J. Belworthy2 and Kevin C. Gough3 1ADAS-UK LTD; Department of Biology; University of Leicester; Leicester, UK; 2Veterinary Laboratories Agency; Surry, KT UK; 3Department of Veterinary Medicine and Science; University of Nottingham; Sutton Bonington, Loughborough UK

Key words: scrapie, evironmental persistence, sPMCA

Ovine scrapie shows considerable horizontal transmission, yet the routes of transmission and specifically the role of fomites in transmission remain poorly defined. Here we present biochemical data demonstrating that on a scrapie-affected sheep farm, scrapie prion contamination is widespread. It was anticipated at the outset that if prions contaminate the environment that they would be there at extremely low levels, as such the most sensitive method available for the detection of PrPSc, serial Protein Misfolding Cyclic Amplification (sPMCA), was used in this study. We investigated the distribution of environmental scrapie prions by applying ovine sPMCA to samples taken from a range of surfaces that were accessible to animals and could be collected by use of a wetted foam swab. Prion was amplified by sPMCA from a number of these environmental swab samples including those taken from metal, plastic and wooden surfaces, both in the indoor and outdoor environment. At the time of sampling there had been no sheep contact with these areas for at least 20 days prior to sampling indicating that prions persist for at least this duration in the environment. These data implicate inanimate objects as environmental reservoirs of prion infectivity which are likely to contribute to disease transmission.

http://www.prion2010.org/bilder/prion_20...00b77af81be3099

Friday, December 14, 2012

DEFRA U.K. What is the risk of Chronic Wasting Disease CWD being introduced into Great Britain? A Qualitative Risk Assessment October 2012

snip...

In the USA, under the Food and Drug Administration’s BSE Feed Regulation (21 CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from deer and elk is prohibited for use in feed for ruminant animals. With regards to feed for non-ruminant animals, under FDA law, CWD positive deer may not be used for any animal feed or feed ingredients. For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law.

Animals considered at high risk for CWD include:

1) animals from areas declared to be endemic for CWD and/or to be CWD eradication zones and

2) deer and elk that at some time during the 60-month period prior to slaughter were in a captive herd that contained a CWD-positive animal.

Therefore, in the USA, materials from cervids other than CWD positive animals may be used in animal feed and feed ingredients for non-ruminants.

The amount of animal PAP that is of deer and/or elk origin imported from the USA to GB can not be determined, however, as it is not specified in TRACES. It may constitute a small percentage of the 8412 kilos of non-fish origin processed animal proteins that were imported from US into GB in 2011.

Overall, therefore, it is considered there is a __greater than negligible risk___ that (nonruminant) animal feed and pet food containing deer and/or elk protein is imported into GB.

There is uncertainty associated with this estimate given the lack of data on the amount of deer and/or elk protein possibly being imported in these products.

snip...

36% in 2007 (Almberg et al., 2011). In such areas, population declines of deer of up to 30 to 50% have been observed (Almberg et al., 2011). In areas of Colorado, the prevalence can be as high as 30% (EFSA, 2011). The clinical signs of CWD in affected adults are weight loss and behavioural changes that can span weeks or months (Williams, 2005). In addition, signs might include excessive salivation, behavioural alterations including a fixed stare and changes in interaction with other animals in the herd, and an altered stance (Williams, 2005). These signs are indistinguishable from cervids experimentally infected with bovine spongiform encephalopathy (BSE). Given this, if CWD was to be introduced into countries with BSE such as GB, for example, infected deer populations would need to be tested to differentiate if they were infected with CWD or BSE to minimise the risk of BSE entering the human food-chain via affected venison.

snip...

The rate of transmission of CWD has been reported to be as high as 30% and can approach 100% among captive animals in endemic areas (Safar et al., 2008).

snip...

In summary, in endemic areas, there is a medium probability that the soil and surrounding environment is contaminated with CWD prions and in a bioavailable form. In rural areas where CWD has not been reported and deer are present, there is a greater than negligible risk the soil is contaminated with CWD prion.

snip...

In summary, given the volume of tourists, hunters and servicemen moving between GB and North America, the probability of at least one person travelling to/from a CWD affected area and, in doing so, contaminating their clothing, footwear and/or equipment prior to arriving in GB is greater than negligible. For deer hunters, specifically, the risk is likely to be greater given the increased contact with deer and their environment. However, there is significant uncertainty associated with these estimates.

snip...

Therefore, it is considered that farmed and park deer may have a higher probability of exposure to CWD transferred to the environment than wild deer given the restricted habitat range and higher frequency of contact with tourists and returning GB residents.

snip...

http://webarchive.nationalarchives.gov.uk/20130822084033/http://www.defra.gov.uk/animal-diseases/files/qra_chronic-wasting-disease-121029.pdf


kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5821586 07/07/15 08:47 PM
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You posted an abstract elsewhere that was pretty disconcerting. However I cannot find the full article anywhere online. If you come across it, please post it. Here was the abstract:

"Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. ***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection."

Re: CWD in Texas [Re: Frio County Hunts] #5821619 07/07/15 09:17 PM
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Are they're any articles published on any die offs of wild deer? There have been a number posted on penned deer getting it, but what about wild herds?

Re: CWD in Texas [Re: jmh004] #5821650 07/07/15 09:34 PM
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Originally Posted By: jmh004
I'm not saying shooting pen raised deer is my thing. But a person ought to be able to decide what to do on their own land don't you think?


Sure they should but not if it affects the health of other wildlife.

Re: CWD in Texas [Re: jmh004] #5821655 07/07/15 09:38 PM
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Originally Posted By: jmh004
Are they're any articles published on any die offs of wild deer? There have been a number posted on penned deer getting it, but what about wild herds?


Only Mass die offs you will find on wild deer or elk is EHD, toxins, starvation.... The quick killers

It's quick enough to be observed...example the 100 plus elk that died in NM in 2013.

You have to remember CWD wasn't discovered until migrating Elk and Mule deer stopped migrating via a fence research enclosure. Yotes, Bears etc have done a good job covering up CWD deaths. Note no CWD has been found in Yotes or Bears or other animals that ate CWD carcasses. Also Note that I'm not a doctorate


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOONER] #5821657 07/07/15 09:40 PM
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Originally Posted By: BOONER
Originally Posted By: jmh004
I'm not saying shooting pen raised deer is my thing. But a person ought to be able to decide what to do on their own land don't you think?


Sure they should but not if it affects the health of other wildlife.


Open season in West Texas border on all free range hoofed animals..... Have fun.. You're a few years late though.



Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: jmh004] #5821697 07/07/15 10:12 PM
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Originally Posted By: jmh004
TPWD is tracking all deer movement into, and out of that ranch in Medina County for the last 5 years. That will pretty much connect every breeder in Texas to this deer in some way. So instead of testing a couple hundred animals on one ranch, they will be able to claim who knows how many animals on who knows how many ranches to test. The breeding industry is about to get hammered.
I don't own a breeding facility, or even work on one is these ranches. I sure will hate to see how many deer are going to be killed in the name of "containment" in the coming months. I'm sure only a few of the most profitable breeders will be the only ones left after all this.
I blame these HF ranches and breeders for a lot of things in today's hunting world. The prices for leases, and basically the price of hunting in general has gone through the roof in recent years in part, what I believe, to these whitetail ranches. That being said, I hate to see the government come in and tell people what to do with their private property. The next few weeks will be very interesting in how the state will handle all this


It's scary. I own a HF ranch with only native deer on it and I don't maintain the fence very well. I know deer can come and go. If one of my HF neighbors imported a deer from that facility, TPWD will want to cull all of their deer AND mine too.

Which brings me to my question. I see TPWD compensated the landowner for the deer. Is there a standard $ figure per deer or do pen raised deer get more $ compared to my puny hill country deer??

Re: CWD in Texas [Re: Frio County Hunts] #5821703 07/07/15 10:15 PM
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So if it is such a slow acting disease, chances are we've all shot a wild deer caring it and consumed it.

Re: CWD in Texas [Re: Frio County Hunts] #5821723 07/07/15 10:29 PM
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Since it seems to be the norm to post links about CWD...here is one that has not been posted that seems interesting.
Link


Are idiots multiplying faster than normal people?[Linked Image]
Re: CWD in Texas [Re: stxranchman] #5821732 07/07/15 10:35 PM
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Originally Posted By: stxranchman
Since it seems to be the norm to post links about CWD...here is one that has not been posted that seems interesting.
Link


Good article, Darwinism at work.

Re: CWD in Texas [Re: Frio County Hunts] #5821733 07/07/15 10:36 PM
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But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.

Re: CWD in Texas [Re: La Longue Carabine] #5821738 07/07/15 10:41 PM
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Originally Posted By: La Longue Carabine
You posted an abstract elsewhere that was pretty disconcerting. However I cannot find the full article anywhere online. If you come across it, please post it. Here was the abstract:

"Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. ***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection."


Sweet Geezus. Would you please get with the program?! Mr tx_biologist has already established that Alzheimer's is caused by CWD. loser8


Crotchety old bastidge
Re: CWD in Texas [Re: jmh004] #5821768 07/07/15 10:54 PM
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Originally Posted By: jmh004
So if it is such a slow acting disease, chances are we've all shot a wild deer caring it and consumed it.


You have a better chance of winning the Texas lottery according to TPWD and biologist. But yes you are correct


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: La Longue Carabine] #5821769 07/07/15 10:55 PM
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Originally Posted By: La Longue Carabine
You posted an abstract elsewhere that was pretty disconcerting. However I cannot find the full article anywhere online. If you come across it, please post it. Here was the abstract:

"Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. ***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection."



the abstract you speak of are papers in progress, and were presented at the Prion2015 conference as abstracts. the finished product will come out soon after (months usually). there was another paper that was interesting as well, and then others from the prion2014 conference. see ;




P.105: RT-QuIC models trans-species prion transmission

Kristen Davenport, Davin Henderson, Candace Mathiason, and Edward Hoover Prion Research Center; Colorado State University; Fort Collins, CO USA

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious. Studies of the effects of primary or tertiary prion protein structures on trans-species prion transmission have relied primarily upon animal bioassays, making the influence of prion protein structure vs. host co-factors (e.g. cellular constituents, trafficking, and innate immune interactions) difficult to dissect. As an alternative strategy, we used real-time quakinginduced conversion (RT-QuIC) to investigate trans-species prion conversion.

To assess trans-species conversion in the RT-QuIC system, we compared chronic wasting disease (CWD) and bovine spongiform encephalopathy (BSE) prions, as well as feline CWD (fCWD) and feline spongiform encephalopathy (FSE). Each prion was seeded into each host recombinant PrP (full-length rPrP of white-tailed deer, bovine or feline). We demonstrated that fCWD is a more efficient seed for feline rPrP than for white-tailed deer rPrP, which suggests adaptation to the new host.

Conversely, FSE maintained sufficient BSE characteristics to more efficiently convert bovine rPrP than feline rPrP. Additionally, human rPrP was competent for conversion by CWD and fCWD. ***This insinuates that, at the level of protein:protein interactions, the barrier preventing transmission of CWD to humans is less robust than previously estimated.

================

***This insinuates that, at the level of protein:protein interactions, the barrier preventing transmission of CWD to humans is less robust than previously estimated.***

================

https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf


old data from the BSE Inquiry way back ;


In conclusion, an analysis of dietary histories revealed statistical associations between various meats/animal products and INCREASED RISK OF CJD. When some account was taken of possible confounding, the association between VEAL EATING AND RISK OF CJD EMERGED AS THE STRONGEST OF THESE ASSOCIATIONS STATISTICALLY. ...

snip...

In the study in the USA, a range of foodstuffs were associated with an increased risk of CJD, including liver consumption which was associated with an apparent SIX-FOLD INCREASE IN THE RISK OF CJD. By comparing the data from 3 studies in relation to this particular dietary factor, the risk of liver consumption became non-significant with an odds ratio of 1.2 (PERSONAL COMMUNICATION, PROFESSOR A. HOFMAN. ERASMUS UNIVERSITY, ROTTERDAM). (???...TSS)

snip...see full report ;

http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/yb/1994/08/00004001.pdf

Thursday, October 10, 2013

*************CJD REPORT 1994 increased risk for consumption of veal and venison and lamb**************

http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-report-1994-increased-risk-for.html

CJD9/10022

October 1994

Mr R.N. Elmhirst Chairman British Deer Farmers Association Holly Lodge Spencers Lane BerksWell Coventry CV7 7BZ

Dear Mr Elmhirst,

CREUTZFELDT-JAKOB DISEASE (CJD) SURVEILLANCE UNIT REPORT

Thank you for your recent letter concerning the publication of the third annual report from the CJD Surveillance Unit. I am sorry that you are dissatisfied with the way in which this report was published.

The Surveillance Unit is a completely independant outside body and the Department of Health is committed to publishing their reports as soon as they become available. In the circumstances it is not the practice to circulate the report for comment since the findings of the report would not be amended. In future we can ensure that the British Deer Farmers Association receives a copy of the report in advance of publication.

The Chief Medical Officer has undertaken to keep the public fully informed of the results of any research in respect of CJD. This report was entirely the work of the unit and was produced completely independantly of the the Department.

The statistical results reqarding the consumption of venison was put into perspective in the body of the report and was not mentioned at all in the press release. Media attention regarding this report was low key but gave a realistic presentation of the statistical findings of the Unit. This approach to publication was successful in that consumption of venison was highlighted only once by the media ie. in the News at one television proqramme.

I believe that a further statement about the report, or indeed statistical links between CJD and consumption of venison, would increase, and quite possibly give damaging credence, to the whole issue. From the low key media reports of which I am aware it seems unlikely that venison consumption will suffer adversely, if at all.

http://web.archive.org/web/20030511010117/http://www.bseinquiry.gov.uk/files/yb/1994/10/00003001.pdf

Thursday, October 10, 2013

*** CJD REPORT 1994 increased risk for consumption of veal and venison and lamb

http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-report-1994-increased-risk-for.html

PLUS, THE CDC DID NOT PUT THIS WARNING OUT FOR THE WELL BEING OF THE DEER AND ELK ;

Thursday, May 26, 2011

Travel History, Hunting, and Venison Consumption Related to Prion Disease Exposure, 2006-2007

FoodNet Population Survey Journal of the American Dietetic Association Volume 111, Issue 6 , Pages 858-863, June 2011.

http://transmissiblespongiformencephalop...nd-venison.html

NOR IS THE FDA recalling this CWD positive elk meat for the well being of the dead elk ;

Wednesday, March 18, 2009

Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II

http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html

now, let’s see what the authors said about this casual link, personal communications years ago. see where it is stated NO STRONG evidence. so, does this mean there IS casual evidence ???? “Our conclusion stating that we found no strong evidence of CWD transmission to humans”

From: TSS (216-119-163-189.ipset45.wt.net) Subject: CWD aka MAD DEER/ELK TO HUMANS ???

Date: September 30, 2002 at 7:06 am PST From: "Belay, Ermias"

To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"

Sent: Monday, September 30, 2002 9:22 AM

Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Dear Sir/Madam,

In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD. That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.

Ermias Belay, M.D. Centers for Disease Control and Prevention

-----Original Message-----

From:

Sent: Sunday, September 29, 2002 10:15 AM

To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV

Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS

Thursday, April 03, 2008

A prion disease of cervids: Chronic wasting disease

2008 1: Vet Res. 2008 Apr 3;39(4):41 A prion disease of cervids: Chronic wasting disease Sigurdson CJ.

snip...

*** twenty-seven CJD patients who regularly consumed venison were reported to the Surveillance Center***,

snip... full text ;

http://chronic-wasting-disease.blogspot.com/2008/04/prion-disease-of-cervids-chronic.html

*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1). ***

https://www.landesbioscience.com/journals/prion/article/28124/?nocache=112223249

*** The potential impact of prion diseases on human health was greatly magnified by the recognition that interspecies transfer of BSE to humans by beef ingestion resulted in vCJD. While changes in animal feed constituents and slaughter practices appear to have curtailed vCJD, there is concern that CWD of free-ranging deer and elk in the U.S. might also cross the species barrier. Thus, consuming venison could be a source of human prion disease. Whether BSE and CWD represent interspecies scrapie transfer or are newly arisen prion diseases is unknown. Therefore, the possibility of transmission of prion disease through other food animals cannot be ruled out. There is evidence that vCJD can be transmitted through blood transfusion. There is likely a pool of unknown size of asymptomatic individuals infected with vCJD, and there may be asymptomatic individuals infected with the CWD equivalent. These circumstances represent a potential threat to blood, blood products, and plasma supplies.

http://cdmrp.army.mil/prevfunded/nprp/NPRP_Summit_Final_Report.pdf

Re: CWD in Texas [Re: jmh004] #5821774 07/07/15 10:57 PM
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Originally Posted By: jmh004
So if it is such a slow acting disease, chances are we've all shot a wild deer caring it and consumed it.


Bingo.... a fact that these scientists and doctors don't seem to wanna talk about


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Re: CWD in Texas [Re: Frio County Hunts] #5821776 07/07/15 10:58 PM
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*** PPo3-7: Prion Transmission from Cervids to Humans is Strain-dependent

*** Here we report that a human prion strain that had adopted the cervid prion protein (PrP) sequence through passage in cervidized transgenic mice efficiently infected transgenic mice expressing human PrP,

*** indicating that the species barrier from cervid to humans is prion strain-dependent and humans can be vulnerable to novel cervid prion strains.

PPo2-27:

Generation of a Novel form of Human PrPSc by Inter-species Transmission of Cervid Prions

*** Our findings suggest that CWD prions have the capability to infect humans, and that this ability depends on CWD strain adaptation, implying that the risk for human health progressively increases with the spread of CWD among cervids.

PPo2-7:

Biochemical and Biophysical Characterization of Different CWD Isolates

*** The data presented here substantiate and expand previous reports on the existence of different CWD strains.

https://www.landesbioscience.com/journals/prion/Prion4-3-PPo2.pdf

Envt.07:

Pathological Prion Protein (PrPTSE) in Skeletal Muscles of Farmed and Free Ranging White-Tailed Deer Infected with Chronic Wasting Disease

***The presence and seeding activity of PrPTSE in skeletal muscle from CWD-infected cervids suggests prevention of such tissue in the human diet as a precautionary measure for food safety, pending on further clarification of whether CWD may be transmissible to humans.

http://www.landesbioscience.com/journals/prion/Prion5-Supp-PrionEnvironment.pdf?nocache=1333529975

>>>CHRONIC WASTING DISEASE , THERE WAS NO ABSOLUTE BARRIER TO CONVERSION OF THE HUMAN PRION PROTEIN<<<

*** PRICE OF CWD TSE PRION POKER GOES UP 2014 ***

Transmissible Spongiform Encephalopathy TSE PRION update January 2, 2014

Wednesday, January 01, 2014

Molecular Barriers to Zoonotic Transmission of Prions

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

http://wwwnc.cdc.gov/eid/article/20/1/13-0858_article.htm

http://chronic-wasting-disease.blogspot.com/2014/01/molecular-barriers-to-zoonotic.html


kind regards, terry

Re: CWD in Texas [Re: jmh004] #5821792 07/07/15 11:04 PM
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Originally Posted By: jmh004
TPWD is tracking all deer movement into, and out of that ranch in Medina County for the last 5 years. That will pretty much connect every breeder in Texas to this deer in some way. So instead of testing a couple hundred animals on one ranch, they will be able to claim who knows how many animals on who knows how many ranches to test. The breeding industry is about to get hammered.
I don't own a breeding facility, or even work on one is these ranches. I sure will hate to see how many deer are going to be killed in the name of "containment" in the coming months. I'm sure only a few of the most profitable breeders will be the only ones left after all this.
I blame these HF ranches and breeders for a lot of things in today's hunting world. The prices for leases, and basically the price of hunting in general has gone through the roof in recent years in part, what I believe, to these whitetail ranches. That being said, I hate to see the government come in and tell people what to do with their private property. The next few weeks will be very interesting in how the state will handle all this

I have heard the same thing about testing and year amount being bumped for 2yrs out to 5yrs now. Also found it interesting that last week the day after the story leaked that 2 ranches who got deer from this breeding ranch offered to kill those deer for testing. Called Austin and they were told to wait. Told to wait????? I guess "they" want to make sure that if any other ranches have CWD that it gets a running head start to make sure it spreads into those deer herds thoroughly. I guess it makes the validation of the impending slaughter more valid to the public eye.....
Sad thing for me is there is more whizzing on corner posts and tires right now than than there is trying to channel our efforts find out the source of what or how CWD got into that deer in that facility. IMO what will happen is the "sky will fall", deer will be slaughtered in very high numbers, compiling info will be used to this to drag this out as long as it can be to allow as many more deer to get CWD...just so that the slaughter can be validated in the uniformed public eye, then the "sky will fall" again, more deer will be slaughtered, sometime in the future while deer are being slaughtered CWD will be found again in another area not even related to this one or any other one...sadly when the real emphasis should be on research to find the source(s) of how it got to those pens....all the emphasis right now is being directed to stopping the deer breeding industry instead of all sides focusing on our real problem- CWD.
CWD was in Texas already in wild free ranging deer before it was found in Central Texas. It did not seem to be to much of a problem since deer were still being allowed to be moved from breeding pens to other breedrs or released on any ranch(LF or HF) or being moved via TTT permits from any ranch in Texas to another ranch. All that was required was a CWD test on a minimum number of or % of deer being moved to qualify. Today, that is much different with CWD now in WT deer in Texas.
I don't think this particular ranch woke up one morning to say "I am going to introduced CWD into Texas". Sadly, they are being convicted in the publics eye of that right now. I do not know of one single ranch or landowner that wanted CWD to be found in Texas but it had been. Those same people to a person never wanted it found in WT deer in Texas. But it happened. It is here and now we have to deal with it. We need to work on find the source of how it got into Central Texas before it shows up again and again.
I had a noted wildlife biologist tell me 12 yrs ago that in his opinion CWD had been or was in Texas already. Pretty sad that I can now tell him...you were right.
Texas has alway been looked at as the leader in wildlife management and research, now is our chance to show why we are the leader.


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Re: CWD in Texas [Re: Frio County Hunts] #5821824 07/07/15 11:18 PM
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Re: CWD in Texas [Re: Frio County Hunts] #5821939 07/08/15 12:16 AM
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Genetic resistance to Scrapie in sheep, is well known and described, it's not a huge leap to think that some lines of deer will also be naturally resistant. The trans species barrier between humans and CWD is significant, but understanding how the barrier was breached, with BSE is important. The process of virulence amplification created by processing sick cattle and sheep into cattle feed is cautionary. Basically, each generation that got directly infused in to cattle through feed, without being exposed to environmental degradation, got a little more infectious until it breached the species barrier.


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Re: CWD in Texas [Re: therancher] #5821961 07/08/15 12:25 AM
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Originally Posted By: therancher
Originally Posted By: La Longue Carabine
You posted an abstract elsewhere that was pretty disconcerting. However I cannot find the full article anywhere online. If you come across it, please post it. Here was the abstract:

"Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. ***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection."


Sweet Geezus. Would you please get with the program?! Mr tx_biologist has already established that Alzheimer's is caused by CWD. loser8



That is not impossible. Although other prions are more likely. We won't know until people actually start getting tested

Re: CWD in Texas [Re: flounder] #5821969 07/08/15 12:31 AM
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Originally Posted By: flounder

*** PPo3-7: Prion Transmission from Cervids to Humans is Strain-dependent

*** Here we report that a human prion strain that had adopted the cervid prion protein (PrP) sequence through passage in cervidized transgenic mice efficiently infected transgenic mice expressing human PrP,

*** indicating that the species barrier from cervid to humans is prion strain-dependent and humans can be vulnerable to novel cervid prion strains.

PPo2-27:

Generation of a Novel form of Human PrPSc by Inter-species Transmission of Cervid Prions

*** Our findings suggest that CWD prions have the capability to infect humans, and that this ability depends on CWD strain adaptation, implying that the risk for human health progressively increases with the spread of CWD among cervids.

PPo2-7:

Biochemical and Biophysical Characterization of Different CWD Isolates

*** The data presented here substantiate and expand previous reports on the existence of different CWD strains.

https://www.landesbioscience.com/journals/prion/Prion4-3-PPo2.pdf

Envt.07:

Pathological Prion Protein (PrPTSE) in Skeletal Muscles of Farmed and Free Ranging White-Tailed Deer Infected with Chronic Wasting Disease

***The presence and seeding activity of PrPTSE in skeletal muscle from CWD-infected cervids suggests prevention of such tissue in the human diet as a precautionary measure for food safety, pending on further clarification of whether CWD may be transmissible to humans.

http://www.landesbioscience.com/journals/prion/Prion5-Supp-PrionEnvironment.pdf?nocache=1333529975

>>>CHRONIC WASTING DISEASE , THERE WAS NO ABSOLUTE BARRIER TO CONVERSION OF THE HUMAN PRION PROTEIN<<<

*** PRICE OF CWD TSE PRION POKER GOES UP 2014 ***

Transmissible Spongiform Encephalopathy TSE PRION update January 2, 2014

Wednesday, January 01, 2014

Molecular Barriers to Zoonotic Transmission of Prions

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

http://wwwnc.cdc.gov/eid/article/20/1/13-0858_article.htm

http://chronic-wasting-disease.blogspot.com/2014/01/molecular-barriers-to-zoonotic.html


kind regards, terry


Is this suppose to mean something? Mice experiments? You guys are way out in lala land if you think this latest research is going to make me or anybody like me stop eating venison because it might have CWD. If it does indeed turn out to be factual that this disease takes years to show the symptoms of the disease you are delusional to believe that deer haven't already been killed and eaten that would of tested positive.


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Re: CWD in Texas [Re: Pitchfork Predator] #5821993 07/08/15 12:41 AM
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Originally Posted By: Pitchfork Predator


Is this suppose to mean something? Mice experiments? You guys are way out in lala land if you think this latest research is going to make me or anybody like me stop eating venison because it might have CWD. If it does indeed turn out to be factual that this disease takes years to show the symptoms of the disease you are delusional to believe that deer haven't already been killed and eaten that would of tested positive.


They aren't normal mice. They're transgenic mice. They have been genetically altered, most likely to have proteins like that of humans, so that researchers can see if the prions can induce changes in human proteins. I have no doubt that people in CWD infected regions have eaten CWD infected meat. But Texas has not yet been identified as on of those regions. So, the question being addressed now is whether it is wise to stop eating wild game before CWD spreads throughout Texas.

It's incredibly depressing. I don't want to give it up. But I don't want dementia even more.

Re: CWD in Texas [Re: Frio County Hunts] #5822003 07/08/15 12:45 AM
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Re: CWD in Texas [Re: jmh004] #5822006 07/08/15 12:45 AM
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Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But in the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.

Last edited by La Longue Carabine; 07/08/15 12:50 AM.
Re: CWD in Texas [Re: La Longue Carabine] #5822009 07/08/15 12:48 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: Pitchfork Predator


Is this suppose to mean something? Mice experiments? You guys are way out in lala land if you think this latest research is going to make me or anybody like me stop eating venison because it might have CWD. If it does indeed turn out to be factual that this disease takes years to show the symptoms of the disease you are delusional to believe that deer haven't already been killed and eaten that would of tested positive.


They aren't normal mice. They're transgenic mice. They have been genetically altered, most likely to have proteins like that of humans, so that researchers can see if the prions can induce changes in human proteins. I have no doubt that people in CWD infected regions have eaten CWD infected meat. But Texas has not yet been identified as on of those regions. So, the question being addressed now is whether it is wise to stop eating wild game before CWD spreads throughout Texas.

It's incredibly depressing. I don't want to give it up. But I don't want dementia even more.


Parts of West Texas ARE identified as part of those regions. 7 wild free ranging animals so far have been found POSITIVE for CWD in the transpecos area.





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Re: CWD in Texas [Re: La Longue Carabine] #5822015 07/08/15 12:50 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?


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Re: CWD in Texas [Re: BOBO the Clown] #5822019 07/08/15 12:52 AM
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Originally Posted By: BOBO the Clown


Parts of West Texas ARE identified as part of those regions. 7 animals so far have been found POSITIVE for CWD in the transpecos area.





Yes I am aware, but it wasn't significant enough to count the whole state as a CWD region

Re: CWD in Texas [Re: La Longue Carabine] #5822027 07/08/15 12:55 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But in the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.

Here is an interesting read...notice the live testing results and the factual replies to the unknowns listing a lot of factors that could be the reasons for the decline...also the deaths number or how they died...interesting to see actual research being done on live deer and live deer testing.
http://billingsgazette.com/news/state-an...07ea837cde.html


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Re: CWD in Texas [Re: BOBO the Clown] #5822044 07/08/15 01:02 AM
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Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?

The South Converse Herd was part of the original cwd detection area

Re: CWD in Texas [Re: La Longue Carabine] #5822049 07/08/15 01:05 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown


Parts of West Texas ARE identified as part of those regions. 7 animals so far have been found POSITIVE for CWD in the transpecos area.





Yes I am aware, but it wasn't significant enough to count the whole state as a CWD region


That because most maps are NOT putting whole states as a region. They are put geographic areas as regions with in states. On top of that most maps haven't been update since 2013. Let's not forget the geographical size of Texas on top of that

That number alone suggest 10-15% CWD rate on that range.


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Re: CWD in Texas [Re: La Longue Carabine] #5822055 07/08/15 01:05 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?

The South Converse Herd was part of the original cwd detection area


And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


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Re: CWD in Texas [Re: Frio County Hunts] #5822070 07/08/15 01:11 AM
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Come on Doc keep googling!!!! We need more pitchforks


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Re: CWD in Texas [Re: BOBO the Clown] #5822077 07/08/15 01:16 AM
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Originally Posted By: BOBO the Clown
And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


If this herd has the highest CWD infection rate of any population, and their population is declining faster than any other population . . . then there is probably an obvious logical connection there.

Last edited by La Longue Carabine; 07/08/15 01:17 AM.
Re: CWD in Texas [Re: Frio County Hunts] #5822155 07/08/15 01:54 AM
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It's funny how people describe hunting. I guided the wealthiest people in the world, including a King while on the King Ranch, which is low fence, and every time I am the one who knew where the deer was and took the hunter to the location and all they did was pull the trigger or release the arrow. Same thing while guiding Elk in Colorado and Canada. I did the scouting and I knew where the Elk were and again, all the hunter did was pull the trigger. I have also had guests that think High Fence hunting is something that they would never do until they couldn't get the animal that they were after and then would go to a neighboring High Fence place to look around and almost always ended up going back to hunt.
I love how we are fast to judge. This is America, let folks hunt as they will. A true trophy is in the eye of the Hunter! If you don't like it then don't do it but don't tell landowners what they can or can't do on their own property or else you are communist and just haven't accepted it yet.
TPWD should be working these folks to better the entire state. All they are about is Power, period. The corrupt and powerful always feel the need for more Power, no matter who they destroy to get it.

Re: CWD in Texas [Re: Frio County Hunts] #5822167 07/08/15 01:59 AM
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Mule Deer populations have been going down for decades now. Drought is a big culprit, habitat destruction, other species taking over. But, sure lets just say it's all CWD. After all, there can only be one reason for anything that happens in nature right?

http://www.texashunting411.com/mule-deer-population-boosted-at-black-gap-wma/

Re: CWD in Texas [Re: Frio County Hunts] #5822182 07/08/15 02:03 AM
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Sorry, my last response was for JMalin. Again, sorry THF, I just really get frustrated with Communism thinking.

Re: CWD in Texas [Re: Bowman24] #5822196 07/08/15 02:07 AM
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Well said

Re: CWD in Texas [Re: La Longue Carabine] #5822218 07/08/15 02:15 AM
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Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown
And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


If this herd has the highest CWD infection rate of any population, and their population is declining faster than any other population . . . then there is probably an obvious logical connection there.


What I find interesting is your ignoring the other 30 plus areas with CWD. Some one such as your self that is highly interested in CWD as of a few THF days ago...would exclude non CWD type morality , expecially in a state that has a 90% migration rate, or a desert area that's also fighting Feds over sage grouse regulations and habitat conservation.

With out the historical environmental tends in front of you I guess:
1)it's easy to say yelp it's all CWD
2) CWD explains low recruitment in sage grouse also... No other reseasonable explanation.
3) don't know why all the other CWD hot spots are holding population numbers and/or swing with envorimental trends but this one should be used as an example of what's going to for sure happen....

Fact of the matter is we are now 67 years into the classification of CWD being a clinical disease. That particular area in Wyoming is now 36 years into the discovery of CWD there( which no one still knows if it was imported or finally identified).... We still have deer, we still have elk.

How is Wisconsin deer herd doing now?


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Bowman24] #5822225 07/08/15 02:18 AM
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Originally Posted By: Bowman24
It's funny how people describe hunting. I guided the wealthiest people in the world, including a King while on the King Ranch, which is low fence, and every time I am the one who knew where the deer was and took the hunter to the location and all they did was pull the trigger or release the arrow. Same thing while guiding Elk in Colorado and Canada. I did the scouting and I knew where the Elk were and again, all the hunter did was pull the trigger. I have also had guests that think High Fence hunting is something that they would never do until they couldn't get the animal that they were after and then would go to a neighboring High Fence place to look around and almost always ended up going back to hunt.
I love how we are fast to judge. This is America, let folks hunt as they will. A true trophy is in the eye of the Hunter! If you don't like it then don't do it but don't tell landowners what they can or can't do on their own property or else you are communist and just haven't accepted it yet.
TPWD should be working these folks to better the entire state. All they are about is Power, period. The corrupt and powerful always feel the need for more Power, no matter who they destroy to get it.


I agree whole hearty!!! But this is about CWD in Texas and America not so much HF, LF or No fence. up


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5822257 07/08/15 02:34 AM
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CWD really might be more serious than we all believe. Think about all these decisions that have happened in DC recently. Is it possible that CWD has infected the grounds of the White House and the Supreme Court? I mean that would explain a lot right??

Last edited by jmh004; 07/08/15 02:35 AM.
Re: CWD in Texas [Re: jmh004] #5822282 07/08/15 02:50 AM
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Originally Posted By: jmh004
CWD really might be more serious than we all believe. Think about all these decisions that have happened in DC recently. Is it possible that CWD has infected the grounds of the White House and the Supreme Court? I mean that would explain a lot right??


CWD is a serious disease with out a doubt!!!!!

It's just not the apocalypse. You have to remember they identified it in 60's. They have mapped it back almost as far as the early 1900's they just now if it was already here or transferred/morphed from sheep some how.

Nature has a funny way of covering stuff up and also working its self out.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOBO the Clown] #5822286 07/08/15 02:52 AM
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Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: jmh004
But I thought CWD was a deer version of Ebola. Something that could wipe out every deer in Texas? According to this article, it may not be all that big of a deal. This article makes too much sense, we better get back on topic.


Evolution can overcome some pretty big hurdles. But it the most CWD saturated zones, CWD is definitely having some dramatic effects. The South Converse Mule Deer Herd in Wyoming has been reduced in population by 60% due to this disease, and the mortality rate isn't showing signs of slowing down.


That's not solely due to CWD.

What about the ORGINAL CWD detection area of CO how are those populations?




to date, officials claim it to be the normal (their normal) one in a million i.e. sporadic CJD.


but ;


*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).

https://www.landesbioscience.com/journals/prion/article/28124/?nocache=112223249


so there goes the neighborhood...


terry

Re: CWD in Texas [Re: BOBO the Clown] #5822309 07/08/15 03:01 AM
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That was just my attempt at a little comic relief for this thread.

Last edited by jmh004; 07/08/15 03:02 AM.
Re: CWD in Texas [Re: jmh004] #5822321 07/08/15 03:07 AM
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Originally Posted By: jmh004
CWD really might be more serious than we all believe. Think about all these decisions that have happened in DC recently. Is it possible that CWD has infected the grounds of the White House and the Supreme Court? I mean that would explain a lot right??



Thursday, January 15, 2015

41-year-old Navy Commander with sporadic Creutzfeldt–Jakob disease CJD TSE Prion: Case Report

http://creutzfeldt-jakob-disease.blogspot.com/2015/01/41-year-old-navy-commander-with.html

Subject: *** Becky Lockhart 46, Utah’s first female House speaker, dies diagnosed with the extremely rare Creutzfeldt-Jakob disease aka mad cow type disease

what is CJD ? just ask USDA inc., and the OIE, they are still feeding the public and the media industry fed junk science that is 30 years old.

why doesn’t some of you try reading the facts, instead of rubber stamping everything the USDA inc says.

sporadic CJD has now been linked to BSE aka mad cow disease, Scrapie, and there is much concern now for CWD and risk factor for humans.

My sincere condolences to the family and friends of the House Speaker Becky Lockhart. I am deeply saddened hear this.

with that said, with great respect, I must ask each and every one of you Politicians that are so deeply saddened to hear of this needless death of the Honorable House Speaker Becky Lockhart, really, cry me a friggen river. I am seriously going to ask you all this...I have been diplomatic for about 17 years and it has got no where. people are still dying. so, are you all stupid or what??? how many more need to die ??? how much is global trade of beef and other meat products that are not tested for the TSE prion disease, how much and how many bodies is this market worth?

Saturday, January 17, 2015

*** Becky Lockhart 46, Utah’s first female House speaker, dies diagnosed with the extremely rare Creutzfeldt-Jakob disease

http://creutzfeldt-jakob-disease.blogspot.com/2015/01/becky-lockhart-46-utahs-first-female.html

*** Human Mad Cow Video

http://zoomify.uzh.ch:8080/zoomify/videos/video-009/video-009.html

*** USA sporadic CJD MAD COW DISEASE HAS HUGE PROBLEM Video

http://zoomify.uzh.ch:8080/zoomify/videos/video-004/video-004.html

*** 1: J Neurol Neurosurg Psychiatry 1994 Jun;57(6):757-8

Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery.

Gibbs CJ Jr, Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek DC.

Laboratory of Central Nervous System Studies, National Institute of

Neurological Disorders and Stroke, National Institutes of Health,

Bethesda, MD 20892.

Stereotactic multicontact electrodes used to probe the cerebral cortex of a middle aged woman with progressive dementia were previously implicated in the accidental transmission of Creutzfeldt-Jakob disease (CJD) to two younger patients. The diagnoses of CJD have been confirmed for all three cases. More than two years after their last use in humans, after three cleanings and repeated sterilisation in ethanol and formaldehyde vapour, the electrodes were implanted in the cortex of a chimpanzee. Eighteen months later the animal became ill with CJD. This finding serves to re-emphasise the potential danger posed by reuse of instruments contaminated with the agents of spongiform encephalopathies, even after scrupulous attempts to clean them.

PMID: 8006664 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query...p;dopt=Abstract

PLEASE NOTE *

Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME.

snip...

The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...

http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf

IATROGENIC TSE PRION

all iatrogenic cjd is, is sporadic CJD, until route and source of the iatrogenic event that took place, is detected, documented, placed in the academic domain as fact, and recorded, which happens very seldom due to a lot of factors, besides the incubation period, and that be mainly industry. kind of like asbestos and tobacco and the industry there from, they knew in the early 1900’s that they both were killing, and they both had long incubation, and somebody chose not to do anything about if for decades and decades. kind of like what we have here with the TSE prion disease. $$$

> In 12 of 15 hospitals with neurosurgical incidents, a decision was made to notify patients of their potential exposure.

SO, X number of patients, from 3 hospitals, where

''exposure to potentially CJD-contaminated instruments ''

took place on these patients, the final decision NOT to tell those folks about the potential exposure to the CJD TSE prion

insane, thus, the TSE prion agent continues to spread. ...please see further comments here ;

http://creutzfeldt-jakob-disease.blogspot.com/2013/11/management-of-neurosurgical-instruments.html

Tuesday, February 11, 2014

Novant Health Forsyth Medical Center Information on potential CJD exposure

http://creutzfeldt-jakob-disease.blogspot.com/2014/02/novant-health-forsyth-medical-center.html

Thursday, June 04, 2015

Catholic Medical Center v. Civil No. 14-cv-180-JL Opinion No. 2015 DNH 110 Fireman’s Fund Insurance Company Creutzfeldt Jakob Disease TSE Prion tainted medical instruments

UNITED STATES DISTRICT COURT DISTRICT OF NEW HAMPSHIRE

http://creutzfeldt-jakob-disease.blogspot.com/2015/06/catholic-medical-center-v-civil-no-14.html

Sunday, March 09, 2014

A Creutzfeldt-Jakob Disease (CJD) Lookback Study: Assessing the Risk of Blood Borne Transmission of Classic Forms of Creutzfeldt-Jakob Disease

FDA TSEAC CIRCUS AND TRAVELING ROAD SHOW FOR THE TSE PRION DISEASES

http://creutzfeldt-jakob-disease.blogspot.com/2014/03/a-creutzfeldt-jakob-disease-cjd.html

Tuesday, March 11, 2014

Science and Technology Committee Oral evidence: Blood, tissue and organ screening, HC 990 Wednesday 5 March 2014 SPORADIC CJD

Actually, it is nearer 2 per million per year of the population will develop sporadic CJD, but your lifetime risk of developing sporadic CJD is about 1 in 30,000. So that has not really changed. When people talk about 1 per million, often they interpret that as thinking it is incredibly rare. They think they have a 1-in-a-million chance of developing this disease. You haven’t. You’ve got about a 1-in-30,000 chance of developing it.

http://creutzfeldt-jakob-disease.blogspot.com/2014/03/science-and-technology-committee-oral.html



terry

Re: CWD in Texas [Re: flounder] #5822460 07/08/15 05:32 AM
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Originally Posted By: flounder

*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).

https://www.landesbioscience.com/journals/prion/article/28124/?nocache=112223249


so there goes the neighborhood...


terry


Let me translate, with sufficient forced amplification, one strain of the CWD prion can be forced to convert human prions. That conversion is most likely to occur in to individuals carrying one out of three possible gene variants. What can't be quantified is the possibility of that amplification occurring outside of a lab. There is no definitive evidence that CWD has crossed the species barrier but there are five cases were, it's unlikely to be the cause of vCJD, but it can't be completely ruled out.

Last edited by nsmike; 07/08/15 02:10 PM.

for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: Frio County Hunts] #5822462 07/08/15 05:48 AM
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Terry spare us the stories about Sporadic CJD it has a very different clinical presentation to vCJD or Mad Cow Disease. Let's confine the discussion to CWD or allied TSE diseases. On the larger scale all prion diseases are related, but the focus of this forum is hunting, lets stick with game animals and their relatives.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: nsmike] #5822480 07/08/15 08:25 AM
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Originally Posted By: nsmike
Terry spare us the stories about Sporadic CJD it has a very different clinical presentation to vCJD or Mad Cow Disease. Let's confine the discussion to CWD or allied TSE diseases. On the larger scale all prion diseases are related, but the focus of this forum is hunting, lets stick with game animals and their relatives.


I, and I'm sure others, are interested in information pertaining to propabilites of human infection by CWD. If in the coming weeks we find out that deer test positive for CWD in multiple locations in Texas, then deciding whether or not to continue eating wild game meat will be on most hunters' minds. And, everyone should make informed decisions for themselves based on the current data available. I'm glad I read one of the articles Terry posted yesterday, because it has changed my perspective on things and made me ask more questions.

Last edited by La Longue Carabine; 07/08/15 08:25 AM.
Re: CWD in Texas [Re: BOBO the Clown] #5822484 07/08/15 08:55 AM
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Originally Posted By: BOBO the Clown
What I find interesting is your ignoring the other 30 plus areas with CWD. Some one such as your self that is highly interested in CWD as of a few THF days ago...would exclude non CWD type morality , expecially in a state that has a 90% migration rate, or a desert area that's also fighting Feds over sage grouse regulations and habitat conservation.

With out the historical environmental tends in front of you I guess:
1)it's easy to say yelp it's all CWD
2) CWD explains low recruitment in sage grouse also... No other reseasonable explanation.
3) don't know why all the other CWD hot spots are holding population numbers and/or swing with envorimental trends but this one should be used as an example of what's going to for sure happen....

Fact of the matter is we are now 67 years into the classification of CWD being a clinical disease. That particular area in Wyoming is now 36 years into the discovery of CWD there( which no one still knows if it was imported or finally identified).... We still have deer, we still have elk.

How is Wisconsin deer herd doing now?

Describing the effects of CWD in the most infected deer population doesnt mean I'm ignoring other CWD locations. It just means I'm describing how bad it can get. I am aware that mule deer populations are declining in other areas as well, including areas where CWD is not prevalent. But, nowhere else are populations dropping as quickly as the South Converse Herd. And I don't think it is a coincidence that they have the highest rate of infection.

I'm not sure where you got 67 and 36 years. CWD was first identified there 48 years ago near the Colorado/ Wyoming border. That was when it was first identified and named.

CWD in Wisconsin is getting worse. Next month they are adding three more counties to the bait ban list due to increasing spread of CWD in those counties.

Here is an article I think I posted in the other thread yesterday. But I'll post it here too because I think it gives a good overview of the situation.
https://www.hcn.org/blogs/goat/chronic-wasting-disease-forgotten-but-not-gone

Last edited by La Longue Carabine; 07/08/15 08:58 AM.
Re: CWD in Texas [Re: Frio County Hunts] #5822611 07/08/15 01:02 PM
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I ment to write 48, 67 was the year.

Regardless if it truly was epidemic we would already be wiped out in Wyoming and especially CO. That's hasn't happened. Drought and winter kills have been much more effective in limiting recruitment then CWD.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: La Longue Carabine] #5822660 07/08/15 01:30 PM
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Originally Posted By: La Longue Carabine
Originally Posted By: nsmike
Terry spare us the stories about Sporadic CJD it has a very different clinical presentation to vCJD or Mad Cow Disease. Let's confine the discussion to CWD or allied TSE diseases. On the larger scale all prion diseases are related, but the focus of this forum is hunting, lets stick with game animals and their relatives.


I, and I'm sure others, are interested in information pertaining to propabilites of human infection by CWD. If in the coming weeks we find out that deer test positive for CWD in multiple locations in Texas, then deciding whether or not to continue eating wild game meat will be on most hunters' minds. And, everyone should make informed decisions for themselves based on the current data available. I'm glad I read one of the articles Terry posted yesterday, because it has changed my perspective on things and made me ask more questions.

I didn't say anything about not linking to information about CWD or vCJD linked to meat. I was referring to Sporadic CJD that has a different clinical presentation. I'm just trying to keep things reasonably on topic not all prion diseases are transmitted through meat.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: La Longue Carabine] #5822682 07/08/15 01:43 PM
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Originally Posted By: La Longue Carabine
Originally Posted By: nsmike
Terry spare us the stories about Sporadic CJD it has a very different clinical presentation to vCJD or Mad Cow Disease. Let's confine the discussion to CWD or allied TSE diseases. On the larger scale all prion diseases are related, but the focus of this forum is hunting, lets stick with game animals and their relatives.


I, and I'm sure others, are interested in information pertaining to propabilites of human infection by CWD. If in the coming weeks we find out that deer test positive for CWD in multiple locations in Texas, then deciding whether or not to continue eating wild game meat will be on most hunters' minds. And, everyone should make informed decisions for themselves based on the current data available. I'm glad I read one of the articles Terry posted yesterday, because it has changed my perspective on things and made me ask more questions.


Informed decisions? This info you lab guys keep posting is suppose to give me an informed decision to make based on people splicing human genes in mice and forcing prions into them? With this type of decision making logic you shouldn't be eating any processed food or meat from the grocery store. Is that the way you guys roll?


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Re: CWD in Texas [Re: nsmike] #5822809 07/08/15 03:11 PM
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Originally Posted By: nsmike
Originally Posted By: flounder

*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).

https://www.landesbioscience.com/journals/prion/article/28124/?nocache=112223249


so there goes the neighborhood...


terry


Let me translate, with sufficient forced amplification, one strain of the CWD prion can be forced to convert human prions. That conversion is most likely to occur in to individuals carrying one out of three possible gene variants. What can't be quantified is the possibility of that amplification occurring outside of a lab. There is no definitive evidence that CWD has crossed the species barrier but there are five cases were, it's unlikely to be the cause of vCJD, but it can't be completely ruled out.


we must not _ASSUME_ that transmission of BSE to other species will invariably present pathology typical of a scrapie-like disease

2005

DEFRA Department for Environment, Food & Rural Affairs

Area 307, London, SW1P 4PQ Telephone: 0207 904 6000 Direct line: 0207 904 6287 E-mail: h.mcdonagh.defra.gsi.gov.uk

GTN: FAX:

Mr T S Singeltary P.O. Box 42 Bacliff Texas USA 77518

21 November 2001

Dear Mr Singeltary

TSE IN HOUNDS

Thank you for e-mail regarding the hounds survey. I am sorry for the long delay in responding.

As you note, the hound survey remains unpublished. However the Spongiform Encephalopathy Advisory Committee (SEAC), the UK Government's independent Advisory Committee on all aspects related to BSE-like disease, gave the hound study detailed consideration at their meeting in January 1994. As a summary of this meeting published in the BSE inquiry noted, the Committee were clearly concerned about the work that had been carried out, concluding that there had clearly been problems with it, particularly the control on the histology, and that it was more or less inconclusive. However was agreed that there should be a re-evaluation of the pathological material in the study.

Later, at their meeting in June 95, The Committee re-evaluated the hound study to see if any useful results could be gained from it. The Chairman concluded that there were varying opinions within the Committee on further work. It did not suggest any further transmission studies and thought that the lack of clinical data was a major weakness.

Overall, it is clear that SEAC had major concerns about the survey as conducted. As a result it is likely that the authors felt that it would not stand up to r~eer review and hence it was never published. As noted above, and in the detailed minutes of the SEAC meeting in June 95, SEAC considered whether additional work should be performed to examine dogs for evidence of TSE infection. Although the Committee had mixed views about the merits of conducting further work, the Chairman noted that when the Southwood Committee made their recommendation to complete an assessment of possible spongiform disease in dogs, no TSEs had been identified in other species and hence dogs were perceived as a high risk population and worthy of study. However subsequent to the original recommendation, made in 1990, a number of other species had been identified with TSE ( e.g. cats) so a study in hounds was less

critical. For more details see- http://www.bseinquiry, gov.uk/files/yb/1995/06/21005001 .pdf

As this study remains unpublished, my understanding is that the ownership of the data essentially remains with the original researchers. Thus unfortunately, I am unable to help with your request to supply information on the hound survey directly. My only suggestion is that you contact one of the researchers originally involved in the project, such as Gerald Wells. He can be contacted at the following address.

Dr Gerald Wells, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, KT 15 3NB, UK

You may also wish to be aware that since November 1994 all suspected cases of spongiform encephalopathy in animals and poultry were made notifiable. Hence since that date there has been a requirement for vets to report any suspect SE in dogs for further investigation. To date there has never been positive identification of a TSE in a dog.

I hope this is helpful

Yours sincerely 4

HUGH MCDONAGH BSE CORRESPONDENCE SECTION

======================================

HOUND SURVEY

I am sorry, but I really could have been a co-signatory of Gerald's minute.

I do NOT think that we can justify devoting any resources to this study, especially as larger and more important projects such as the pathogenesis study will be quite demanding.

If there is a POLITICAL need to continue with the examination of hound brains then it should be passed entirely to the VI Service.

J W WILESMITH Epidemiology Unit 18 October 1991

Mr. R Bradley

cc: Mr. G A H Wells

http://collections.europarchive.org/tna/20081106102318/http://www.bseinquiry.gov.uk/files/yb/1991/10/18001001.pdf

3.3. Mr R J Higgins in conjunction with Mr G A Wells and Mr A C Scott would by the end of the year, indentify the three brains that were from the ''POSITIVE'' end of the lesion spectrum.

http://collections.europarchive.org/tna/20080103034308/http://www.bseinquiry.gov.uk/files/yb/1993/12/06001001.pdf

TSE in dogs have not been documented simply because OF THE ONLY STUDY, those brain tissue samples were screwed up too. see my investigation of this here, and to follow, later follow up, a letter from defra, AND SEE SUSPICIOUS BRAIN TISSUE SAF's. ...TSS

http://www.mad-cow.org/00/aug00_late_news.html#ggg

TSE & HOUNDS

GAH WELLS (very important statement here...TSS)

HOUND STUDY

*** AS implied in the Inset 25 we must not _ASSUME_ that transmission of BSE to other species will invariably present pathology typical of a scrapie-like disease.

snip...

http://web.archive.org/web/20060307063542/http://www.bseinquiry.gov.uk/files/yb/1991/01/04004001.pdf



terry


p.s.


Monday, February 14, 2011

THE ROLE OF PREDATION IN DISEASE CONTROL: A COMPARISON OF SELECTIVE AND NONSELECTIVE REMOVAL ON PRION DISEASE DYNAMICS IN DEER

NO, NO, NOT NO, BUT HELL NO !

Journal of Wildlife Diseases, 47(1), 2011, pp. 78-93 © Wildlife Disease Association 2011

http://chronic-wasting-disease.blogspot.com/2011/02/role-of-predation-in-disease-control.html

OR-09: Canine spongiform encephalopathy—A new form of animal prion disease

Monique David, Mourad Tayebi UT Health; Houston, TX USA

It was also hypothesized that BSE might have originated from an unrecognized sporadic or genetic case of bovine prion disease incorporated into cattle feed or even cattle feed contaminated with prion-infected human remains.1 However, strong support for a genetic origin of BSE has recently been demonstrated in an H-type BSE case exhibiting the novel mutation E211K.2 Furthermore, a specific prion protein strain causing BSE in cattle is believed to be the etiological agent responsible for the novel human prion disease, variant Creutzfeldt-Jakob disease (vCJD).3 Cases of vCJD have been identified in a number countries, including France, Italy, Ireland, the Netherlands, Canada, Japan, US and the UK with the largest number of cases. Naturally occurring feline spongiform encephalopathy of domestic cats4 and spongiform encephalopathies of a number of zoo animals so-called exotic ungulate encephalopathies5,6 are also recognized as animal prion diseases, and are thought to have resulted from the same BSE-contaminated food given to cattle and humans, although and at least in some of these cases, a sporadic and/or genetic etiology cannot be ruled out. The canine species seems to display resistance to prion disease and no single case has so far been reported.7,8 Here, we describe a case of a 9 week old male Rottweiler puppy presenting neurological deficits; and histological examination revealed spongiform vacuolation characteristic of those associated with prion diseases.9 Initial biochemical studies using anti-PrP antibodies revealed the presence of partially proteinase K-resistant fragment by western blotting. Furthermore, immunohistochemistry revealed spongiform degeneration consistent with those found in prion disease and displayed staining for PrPSc in the cortex.

Of major importance, PrPSc isolated from the Rottweiler was able to cross the species barrier transmitted to hamster in vitro with PMCA and in vivo (one hamster out of 5). Futhermore, second in vivo passage to hamsters, led to 100% attack rate (n = 4) and animals displayed untypical lesional profile and shorter incubation period.

In this study, we show that the canine species might be sensitive to prion disease and that PrPSc isolated from a dog can be transmitted to dogs and hamsters in vitro using PMCA and in vivo to hamsters.

If our preliminary results are confirmed, the proposal will have a major impact on animal and public health and would certainly lead to implementing new control measures for ‘canine spongiform encephalopathy’ (CSE).

References 1. Colchester AC, Colchester NT. The origin of bovine spongiform encephalopathy: the human prion disease hypothesis. Lancet 2005; 366:856-61; PMID:16139661; http:// dx.doi.org/10.1016/S0140-6736(05)67218-2.

2. Richt JA, Hall SM. BSE case associated with prion protein gene mutation. PLoS Pathog 2008; 4:e1000156; PMID:18787697; http://dx.doi.org/10.1371/journal. ppat.1000156.

3. Collinge J. Human prion diseases and bovine spongiform encephalopathy (BSE). Hum Mol Genet 1997; 6:1699-705; PMID:9300662; http://dx.doi.org/10.1093/ hmg/6.10.1699.

4. Wyatt JM, Pearson GR, Smerdon TN, Gruffydd-Jones TJ, Wells GA, Wilesmith JW. Naturally occurring scrapie-like spongiform encephalopathy in five domestic cats. Vet Rec 1991; 129:233-6; PMID:1957458; http://dx.doi.org/10.1136/vr.129.11.233.

5. Jeffrey M, Wells GA. Spongiform encephalopathy in a nyala (Tragelaphus angasi). Vet Pathol 1988; 25:398-9; PMID:3232315; http://dx.doi.org/10.1177/030098588802500514.

6. Kirkwood JK, Wells GA, Wilesmith JW, Cunningham AA, Jackson SI. Spongiform encephalopathy in an arabian oryx (Oryx leucoryx) and a greater kudu (Tragelaphus strepsiceros). Vet Rec 1990; 127:418-20; PMID:2264242.

7. Bartz JC, McKenzie DI, Bessen RA, Marsh RF, Aiken JM. Transmissible mink encephalopathy species barrier effect between ferret and mink: PrP gene and protein analysis. J Gen Virol 1994; 75:2947-53; PMID:7964604; http://dx.doi.org/10.1099/0022-1317- 75-11-2947.

8. Lysek DA, Schorn C, Nivon LG, Esteve-Moya V, Christen B, Calzolai L, et al. Prion protein NMR structures of cats, dogs, pigs, and sheep. Proc Natl Acad Sci U S A 2005; 102:640-5; PMID:15647367; http://dx.doi.org/10.1073/pnas.0408937102.

9. Budka H. Neuropathology of prion diseases. Br Med Bull 2003; 66:121-30; PMID:14522854; http://dx.doi.org/10.1093/bmb/66.1.121.

http://www.landesbioscience.com/journals/prion/01-Prion6-2-OralPresentations.pdf

Monday, March 26, 2012

CANINE SPONGIFORM ENCEPHALOPATHY: A NEW FORM OF ANIMAL PRION DISEASE

http://caninespongiformencephalopathy.blogspot.com/2012/03/canine-spongiform-encephalopathy-new.html

Monday, March 8, 2010

Canine Spongiform Encephalopathy aka MAD DOG DISEASE

http://caninespongiformencephalopathy.blogspot.com/


terry


Last edited by flounder; 07/08/15 03:16 PM.
Re: CWD in Texas [Re: BOBO the Clown] #5822824 07/08/15 03:17 PM
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Originally Posted By: BOBO the Clown
Originally Posted By: Bowman24
It's funny how people describe hunting. I guided the wealthiest people in the world, including a King while on the King Ranch, which is low fence, and every time I am the one who knew where the deer was and took the hunter to the location and all they did was pull the trigger or release the arrow. Same thing while guiding Elk in Colorado and Canada. I did the scouting and I knew where the Elk were and again, all the hunter did was pull the trigger. I have also had guests that think High Fence hunting is something that they would never do until they couldn't get the animal that they were after and then would go to a neighboring High Fence place to look around and almost always ended up going back to hunt.
I love how we are fast to judge. This is America, let folks hunt as they will. A true trophy is in the eye of the Hunter! If you don't like it then don't do it but don't tell landowners what they can or can't do on their own property or else you are communist and just haven't accepted it yet.
TPWD should be working these folks to better the entire state. All they are about is Power, period. The corrupt and powerful always feel the need for more Power, no matter who they destroy to get it.


I agree whole hearty!!! But this is about CWD in Texas and America not so much HF, LF or No fence. up



I agree. But, the folks who want to ban high fences are going to do their best to tie CWD to "pens" regardless of how big. Everyone with an agenda will use it for their personal favorite, we've already seen it tied to Alzheimer's and sage grouse etc.

All logic is tossed out when a good crisis presents itself.

Last edited by therancher; 07/08/15 03:18 PM.

Crotchety old bastidge
Re: CWD in Texas Feline Spongiform Encephalopathy and CWD [Re: Frio County Hunts] #5822834 07/08/15 03:21 PM
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By comparing the amount of PK-resistant prion protein in the two substrates, an assessment of the host’s species barrier can be made. We show that the CER assay correctly predicts known prion species barriers of laboratory mice and, as an example, show some preliminary results suggesting that bobcats (Lynx rufus) may be susceptible to white-tailed deer (Odocoileus virginianus) chronic wasting disease agent.

http://www.jove.com/video/52522/assessing-transmissible-spongiform-encephalopathy-species-barriers


>>> show some preliminary results suggesting that bobcats (Lynx rufus) may be susceptible to white-tailed deer (Odocoileus virginianus) chronic wasting disease agent.


AD.63: Susceptibility of domestic cats to chronic wasting disease

Amy V.Nalls,1 Candace Mathiason,1 Davis Seelig,2 Susan Kraft,1 Kevin Carnes,1 Kelly Anderson,1 Jeanette Hayes-Klug1 and Edward A. Hoover1

1Colorado State University; Fort Collins, CO USA; 2University of Minnesota; Saint Paul, MN USA

Domestic and nondomestic cats have been shown to be susceptible to feline spongiform encephalopathy (FSE), almost certainly caused by consumption of bovine spongiform encephalopathy (BSE)-contaminated meat. Because domestic and free-ranging nondomestic felids scavenge cervid carcasses, including those in areas affected by chronic wasting disease (CWD), we evaluated the susceptibility of the domestic cat (Felis catus) to CWD infection experimentally. Cohorts of 5 cats each were inoculated either intracerebrally (IC) or orally (PO) with CWD-infected deer brain. At 40 and 42 mo post-inoculation, two IC-inoculated cats developed signs consistent with prion disease, including a stilted gait, weight loss, anorexia, polydipsia, patterned motor behaviors, head and tail tremors, and ataxia, and progressed to terminal disease within 5 mo. Brains from these two cats were pooled and inoculated into cohorts of cats by IC, PO, and intraperitoneal and subcutaneous (IP/SC) routes. Upon subpassage, feline-adapted CWD (FelCWD) was transmitted to all IC-inoculated cats with a decreased incubation period of 23 to 27 mo. FelCWD was detected in the brains of all the symptomatic cats by western blotting and immunohistochemistry and abnormalities were seen in magnetic resonance imaging, including multifocal T2 fluid attenuated inversion recovery (FLAIR) signal hyper-intensities, ventricular size increases, prominent sulci, and white matter tract cavitation. Currently, 3 of 4 IP/SQ and 2 of 4 PO inoculared cats have developed abnormal behavior patterns consistent with the early stage of feline CWD. These results demonstrate that CWD can be transmitted and adapted to the domestic cat, thus raising the issue of potential cervid-to- feline transmission in nature.

http://www.prion2013.ca/tiny_uploads/forms/Scientific-Program.pdf

www.landesbioscience.com

PO-081: Chronic wasting disease in the cat— Similarities to feline spongiform encephalopathy (FSE)

http://www.landesbioscience.com/journals/prion/04-Prion6-2-Pathogenesis-and-pathology.pdf

http://chronic-wasting-disease.blogspot.com/2012/05/chronic-wasting-disease-cwd-prion2012.html

http://www.prion2011.ca/files/PRION_2011_-_Posters_(May_5-11).pdf

http://felinespongiformencephalopathyfse...ats-to-cwd.html

PO-081: Chronic wasting disease in the cat— Similarities to feline spongiform encephalopathy (FSE)

http://www.landesbioscience.com/journals/prion/04-Prion6-2-Pathogenesis-and-pathology.pdf

http://chronic-wasting-disease.blogspot.com/2012/05/chronic-wasting-disease-cwd-prion2012.html

Thursday, May 31, 2012

CHRONIC WASTING DISEASE CWD PRION2012 Aerosol, Inhalation transmission, Scrapie, cats, species barrier, burial, and more

http://chronic-wasting-disease.blogspot.com/2012/05/chronic-wasting-disease-cwd-prion2012.html

Monday, August 8, 2011

Susceptibility of Domestic Cats to CWD Infection

http://felinespongiformencephalopathyfse...ats-to-cwd.html

Sunday, August 25, 2013

Prion2013 Chronic Wasting Disease CWD risk factors, humans, domestic cats, blood, and mother to offspring transmission

http://chronic-wasting-disease.blogspot.com/2013/08/prion2013-chronic-wasting-disease-cwd.html

Feline Spongiform Encephalopathy (FSE) FSE was first identified in the UK in 1990. Most cases have been reported in the UK, where the epidemic has been consistent with that of the BSE epidemic. Some other countries (e.g. Norway, Liechtenstein and France) have also reported cases.

Most cases have been reported in domestic cats but there have also been cases in captive exotic cats (e.g. Cheetah, Lion, Asian leopard cat, Ocelot, Puma and Tiger). The disease is characterised by progressive nervous signs, including ataxia, hyper-reactivity and behavioural changes and is fatal.

The chemical and biological properties of the infectious agent are identical to those of the BSE and vCJD agents. These findings support the hypothesis that the FSE epidemic resulted from the consumption of food contaminated with the BSE agent.

The FSE epidemic has declined as a result of tight controls on the disposal of specified risk material and other animal by-products.

References: Leggett, M.M. et al.(1990) A spongiform encephalopathy in a cat. Veterinary Record. 127. 586-588

Synge, B.A. et al. (1991) Spongiform encephalopathy in a Scottish cat. Veterinary Record. 129. 320

Wyatt, J. M. et al. (1991) Naturally occurring scrapie-like spongiform encephalopathy in five domestic cats. Veterinary Record. 129. 233.

Gruffydd-Jones, T. J.et al.. (1991) Feline spongiform encephalopathy. J. Small Animal Practice. 33. 471-476.

Pearson, G. R. et al. (1992) Feline spongiform encephalopathy: fibril and PrP studies. Veterinary Record. 131. 307-310.

Willoughby, K. et al. (1992) Spongiform encephalopathy in a captive puma (Felis concolor). Veterinary Record. 131. 431-434.

Fraser, H. et al. (1994) Transmission of feline spongiform encephalopathy to mice. Veterinary Record 134. 449.

Bratberg, B. et al. (1995) Feline spongiform encephalopathy in a cat in Norway. Veterinary Record 136. 444

Baron, T. et al. (1997) Spongiform encephalopathy in an imported cheetah in France. Veterinary Record 141. 270-271

Zanusso, G et al. (1998) Simultaneous occurrence of spongiform encephalopathy in a man and his cat in Italy. Lancet, V352, N9134, OCT 3, Pp 1116-1117.

Ryder, S.J. et al. (2001) Inconsistent detection of PrP in extraneural tissues of cats with feline spongiform encephalopathy. Veterinary Record 146. 437-441

Kelly, D.F. et al. (2005) Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy. Veterinary Record 156. 472-477.

http://archive.defra.gov.uk/foodfarm/farmanimal/diseases/atoz/bse/othertses/index.htm#fse

3 further cheetah cases have occured, plus 1 lion, plus all the primates, and 20 additional house cats. Nothing has been published on any of these UK cases either. One supposes the problem here with publishing is that many unpublished cases were _born_ long after the feed "ban". Caught between a rock and a hard place: leaky ban or horizontal transmission (or both).

http://www.mad-cow.org/may99_zoo_news.html

http://www.mad-cow.org/00/aug00_late_news.html#ggg

YOU explained that imported crushed heads were extensively used in the petfood industry...

http://web.archive.org/web/20060303042720/http://www.bseinquiry.gov.uk/files/yb/1989/04/14001001.pdf

In particular I do not believe one can say that the levels of the scrapie agent in pet food are so low that domestic animals are not exposed...

http://web.archive.org/web/20040301231838/http://www.bseinquiry.gov.uk/files/yb/1989/04/24003001.pdf

http://web.archive.org/web/20060303042732/http://www.bseinquiry.gov.uk/files/yb/1989/04/25001001.pdf

on occassions, materials obtained from slaughterhouses will be derived from sheep affected with scrapie or cattle that may be incubating BSE for use in petfood manufacture...

http://web.archive.org/web/20060303042739/http://www.bseinquiry.gov.uk/files/yb/1989/05/03007001.pdf

*** Meldrum's notes on pet foods and materials used

http://web.archive.org/web/20060303042745/http://www.bseinquiry.gov.uk/files/yb/1989/05/16001001.pdf

*** BSE & Pedigree Petfoods ***

http://web.archive.org/web/20060303042725/http://www.bseinquiry.gov.uk/files/yb/1989/05/16002001.pdf



terry

Re: CWD in Texas [Re: Pitchfork Predator] #5822845 07/08/15 03:26 PM
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Originally Posted By: Pitchfork Predator
Originally Posted By: La Longue Carabine
Originally Posted By: nsmike
Terry spare us the stories about Sporadic CJD it has a very different clinical presentation to vCJD or Mad Cow Disease. Let's confine the discussion to CWD or allied TSE diseases. On the larger scale all prion diseases are related, but the focus of this forum is hunting, lets stick with game animals and their relatives.


I, and I'm sure others, are interested in information pertaining to propabilites of human infection by CWD. If in the coming weeks we find out that deer test positive for CWD in multiple locations in Texas, then deciding whether or not to continue eating wild game meat will be on most hunters' minds. And, everyone should make informed decisions for themselves based on the current data available. I'm glad I read one of the articles Terry posted yesterday, because it has changed my perspective on things and made me ask more questions.


Informed decisions? This info you lab guys keep posting is suppose to give me an informed decision to make based on people splicing human genes in mice and forcing prions into them? With this type of decision making logic you shouldn't be eating any processed food or meat from the grocery store. Is that the way you guys roll?




Sunday, June 14, 2015

Larry’s Custom Meats Inc. Recalls Beef Tongue Products That May Contain Specified Risk Materials BSE TSE Prion

http://madcowusda.blogspot.com/2015/06/larrys-custom-meats-inc-recalls-beef.html



terry


terry

Re: CWD in Texas [Re: La Longue Carabine] #5822847 07/08/15 03:28 PM
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Originally Posted By: La Longue Carabine
Originally Posted By: nsmike
Terry spare us the stories about Sporadic CJD it has a very different clinical presentation to vCJD or Mad Cow Disease. Let's confine the discussion to CWD or allied TSE diseases. On the larger scale all prion diseases are related, but the focus of this forum is hunting, lets stick with game animals and their relatives.


I, and I'm sure others, are interested in information pertaining to propabilites of human infection by CWD. If in the coming weeks we find out that deer test positive for CWD in multiple locations in Texas, then deciding whether or not to continue eating wild game meat will be on most hunters' minds. And, everyone should make informed decisions for themselves based on the current data available. I'm glad I read one of the articles Terry posted yesterday, because it has changed my perspective on things and made me ask more questions.


I have a better idea. Why don't you and terry start a CJD thread and let this thread stay on topic? Evidently most of us here aren't influenced much by scare tactics, and are much more interested in the facts as they pertain to CWD.... You know, the original subject of this thread?

Go tell someone else somewhere else that the sky is falling.


Crotchety old bastidge
Re: CWD in Texas [Re: BOBO the Clown] #5822854 07/08/15 03:35 PM
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Originally Posted By: BOBO the Clown
Originally Posted By: La Longue Carabine
Originally Posted By: BOBO the Clown
And so was the CO side and it has rebounded some years and stayed steady others. I find it humors that now CWD is the overall culprit for historic mulie deer decline nation wide...What about elk population growth?


If this herd has the highest CWD infection rate of any population, and their population is declining faster than any other population . . . then there is probably an obvious logical connection there.


What I find interesting is your ignoring the other 30 plus areas with CWD. Some one such as your self that is highly interested in CWD as of a few THF days ago...would exclude non CWD type morality , expecially in a state that has a 90% migration rate, or a desert area that's also fighting Feds over sage grouse regulations and habitat conservation.

With out the historical environmental tends in front of you I guess:
1)it's easy to say yelp it's all CWD
2) CWD explains low recruitment in sage grouse also... No other reseasonable explanation.
3) don't know why all the other CWD hot spots are holding population numbers and/or swing with envorimental trends but this one should be used as an example of what's going to for sure happen....

Fact of the matter is we are now 67 years into the classification of CWD being a clinical disease. That particular area in Wyoming is now 36 years into the discovery of CWD there( which no one still knows if it was imported or finally identified).... We still have deer, we still have elk.

How is Wisconsin deer herd doing now?





Thursday, June 25, 2015

Wisconsin CWD-positive white-tailed deer found on Eau Claire County farm

http://chronic-wasting-disease.blogspot.com/2015/06/wisconsin-cwd-positive-white-tailed.html


Wednesday, March 04, 2015

*** Disease sampling results provide current snapshot of CWD in Wisconsin finding 324 positive detections statewide in 2014

http://chronic-wasting-disease.blogspot.com/2015/03/disease-sampling-results-provide.html


Tuesday, October 07, 2014

*** Wisconsin white-tailed deer tested positive for CWD on a Richland County breeding farm, and a case of CWD has been discovered on a Marathon County hunting preserve

http://chronic-wasting-disease.blogspot.com/2014/10/wisconsin-white-tailed-deer-tested.html


see;

‘’It is interesting to note that, in 2001, the State of Texas shifted its deer management strategies toward the same leanings that Kroll has suggested for Wisconsin. In Texas, the change was brought about via heavy lobbying from the high-fence deer ranching industry. This pressure helped convince the Texas Parks and Wildlife to change their regulations and allow private landowners to select the own deer biologists.’’

nothing like the wolf guarding the henhouse.

Texas just documented another case of CWD, I wonder what the Wisconsin’s Deer Czar (from TEXAS), seems Dr. Dough’s passive approach on CWD is not working out too well.

yep, while the Texas deer czar dr. dough was off to Wisconsin pushing the privately owned shooting pen industry (livestock cervid industry), Texas fell to CWD, and have now documented 7 cases of CWD to date.

IF Texas would test for CWD in the captive industry aggressively, I think we would all be shocked as to what they would find.

for your information...

According to Wisconsin’s White-Tailed Deer Trustee Dr. James Kroll, people who call for more public hunting opportunities are “pining for socialism.” He further states, “(Public) Game management is the last bastion of communism.”

“Game Management,” says James Kroll, driving to his high-fenced, two-hundred-acre spread near Nacogdoches, “is the last bastion of communism.” Kroll, also known as Dr. Deer, is the director of the Forestry Resources Institute of Texas at Stephen F. Austin State University, and the “management” he is referring to is the sort practiced by the State of Texas. The 55-year-old Kroll is the leading light in the field of private deer management as a means to add value to the land. His belief is so absolute that some detractors refer to him as Dr. Dough, implying that his eye is on the bottom line more than on the natural world.

Kroll, who has been the foremost proponent of deer ranching in Texas for more than thirty years, doesn’t mind the controversy and certainly doesn’t fade in the heat. People who call for more public lands are “cocktail conservationists,” he says, who are really pining for socialism. He calls national parks “wildlife ghettos” and flatly accuses the government of gross mismanagement. He argues that his relatively tiny acreage, marked by eight-foot fences and posted signs warning off would-be poachers, is a better model for keeping what’s natural natural while making money off the land.

Dr. Deer Wisconsin Report: Will High-Fence Bias Skew Final Plan?

Categories: Blogs, Daniel Schmidt's Whitetail Wisdom, Deer News, Featured Tags: antler restricitons, dan schmidt, Dr. Deer, james kroll, James Kroll Wisconsin, qdm, quality deer management, texas hunting, wisconsin deer hunting March 29, 2012 According to Wisconsin’s White-Tailed Deer Trustee Dr. James Kroll, people who call for more public hunting opportunities are “pining for socialism.” He further states, “(Public) Game management is the last bastion of communism.”

OPINION BLOG

These are just two insights into the man who has been asked to provide analysis and recommended changes to Wisconsin’s deer management program. Kroll’s insights are from an article entitled “Which Side of the Fence Are You On?” by Joe Nick Patoski for a past edition of Texas Monthly. If nothing more, the article gives an unabashed look into the mind-set that will be providing the Wisconsin DNR with recommendations on how to change their deer management practices. James Kroll (also known as “Deer Dr.”) was appointed to the Wisconsin “deer czar” position last fall. He was hired by the Department of Administration and instructed to complete a review of the state’s deer management program.

Here’s a sample of the article:

“Game Management,” says James Kroll, driving to his high-fenced, two-hundred-acre spread near Nacogdoches, “is the last bastion of communism.” Kroll, also known as Dr. Deer, is the director of the Forestry Resources Institute of Texas at Stephen F. Austin State University, and the “management” he is referring to is the sort practiced by the State of Texas. The 55-year-old Kroll is the leading light in the field of private deer management as a means to add value to the land. His belief is so absolute that some detractors refer to him as Dr. Dough, implying that his eye is on the bottom line more than on the natural world.

Kroll, who has been the foremost proponent of deer ranching in Texas for more than thirty years, doesn’t mind the controversy and certainly doesn’t fade in the heat. People who call for more public lands are “cocktail conservationists,” he says, who are really pining for socialism. He calls national parks “wildlife ghettos” and flatly accuses the government of gross mismanagement. He argues that his relatively tiny acreage, marked by eight-foot fences and posted signs warning off would-be poachers, is a better model for keeping what’s natural natural while making money off the land.

A trip to South Africa six years ago convinced Kroll that he was on the right track. There he encountered areas of primitive, lush wildlife-rich habitats called game ranches. They were privately owned, privately managed, and enclosed by high fences. He noticed how most of the land outside those fences had been grazed to the nub, used up. “Game ranches there derive their income from these animals — viewing them, hunting them, selling their meat,” he says. “There are no losers.” At his own ranch Kroll has set up a smaller version of the same thing. His land is indeed lush, verdant, with pine groves, an abundance of undergrowth, wild orchids, New Jersey tea, jack-in-the-pulpits, and other native plants. He has also set up a full-scale breeding research center and is one of twenty Texas deer breeders using artificial insemination to improve his herd. “We balance sex and age ratio,” he says. “We manage habitat. We control the population and manage for hunting. I want to leave the deer herd better than it was before we came.”

It is interesting to note that, in 2001, the State of Texas shifted its deer management strategies toward the same leanings that Kroll has suggested for Wisconsin. In Texas, the change was brought about via heavy lobbying from the high-fence deer ranching industry. This pressure helped convince the Texas Parks and Wildlife to change their regulations and allow private landowners to select the own deer biologists.

“That has given landowners more freedom,” Kroll told Texas Monthly. “(However,) You still have to let the state on your land to get a wildlife-management permit.” The key difference here is that 98 percent of Texas is comprised of private land. Wisconsin, on the other hand, consists of approximately 34.8 million acres of land, and 25.5 percent of the state’s 638,000 gun-hunters reported hunting on public land at some point during the season (2010, Duey, Rees).

According to the Wisconsin Realtors Association, more than 5.7 million acres of this land, or 16.5 percent, is publicly owned and used for parks, forests, trails, and natural resource protection. [Note: these statistics do not include the public land used for roads, government buildings, military bases, and college/school campuses.] This 5.7 million acres of public land is owned as follows:

Federal government owns approximately 1.5 million acres (4.4 percent of the state’s land area). Almost all of the federal forestland in Wisconsin is located in Chequamegon-Nicolet National Forest.

State government owns approximately 1.6 million acres (4.6 percent of the state’s land area). The land is managed by two agencies, the Board of Commissioners of Public Land (who manages lands granted by federal government) and the DNR (managing land owned by the state).

County government owns approximately 2.6 million acres (7.5 percent of the state’s land area).

Public land is located in 71 of Wisconsin’s 72 counties, with the most public land located in Bayfield County (464,673 acres). [Note: Menominee County does not have any public land, but 98 percent of the land is held in trust by the Menominee Tribe.] Twenty counties have more than 100,000 acres of public land, while only 12 counties have fewer than 10,000 acres.

What does this all mean? My initial reaction, which is one that I predicted when Kroll was named to the state’s deer trustee position, is that his team’s final recommendations — if implemented — will be heavily skewed toward the state’s larger landowners (500+ acres) and folks who own small parcels in areas comprised mostly of private land.

It is also my prediction that the final recommendations (again, if implemented) will do little, if anything, to improve deer herds and deer hunting on Wisconsin’s 5.7 million acres of public land.

Where does this leave the public-land hunter? “It will suck to be you,” said one deer manager who asked to remain anonymous out of fear for his job. “The resources and efforts will go toward improving the private land sector. This is all about turning deer hunting away from the Public Land Doctrine and more toward a European-style of management — like they have in Texas.”

I do, of course, hope these assumptions are wrong. As with all things in life, we should maintain an open mind to change. Life is all about change. However, change for the sake of change is usually a recipe for disaster. Especially when that change is driven by something more than a sincere desire to manage public resources for the greater good.

As noted yesterday (Dr. James Kroll Report: Is That All You Get For Your Money), I will provide more of my opinions and interpretation on this important issue in forthcoming installments of this blog. Read his full preliminary report here.

http://www.texasmonthly.com/story/which-side-fence-are-you

http://www.texasmonthly.com/preview/2002-02-01/feature5

http://www.deeranddeerhunting.com/deer-n...skew-final-plan

snip...see full text ;

Thursday, March 29, 2012

TEXAS DEER CZAR SAYS WISCONSIN DNR NOT DOING ENOUGH ABOUT CWD LIKE POT CALLING KETTLE BLACK

http://chronic-wasting-disease.blogspot.com/2012/03/texas-deer-czar-says-wisconsin-dnr-not.html

Friday, June 01, 2012

*** TEXAS DEER CZAR TO WISCONSIN ASK TO EXPLAIN COMMENTS

http://chronic-wasting-disease.blogspot.com/2012/06/texas-deer-czar-to-wisconsin-ask-to.html

Tuesday, July 10, 2012

Dr. James C. Kroll Texas deer czar final report on Wisconsin

http://chronic-wasting-disease.blogspot.com/2012/07/dr-james-c-kroll-texas-deer-czar-final.html

Wednesday, March 18, 2015

Chronic Wasting Disease CWD Confirmed Texas Trans Pecos March 18, 2015

http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-confirmed.html

Wednesday, March 25, 2015

Chronic Wasting Disease CWD Cases Confirmed In New Mexico 2013 and 2014 UPDATE 2015

http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-cases.html



UPDATED CORRESPONDENCE FROM AUTHORS OF THIS STUDY I.E. COLBY, PRUSINER ET AL, ABOUT MY CONCERNS OF THE DISCREPANCY BETWEEN THEIR FIGURES AND MY FIGURES OF THE STUDIES ON CWD TRANSMISSION TO CATTLE ;

----- Original Message -----

From: David Colby To: flounder9@verizon.net

Cc: stanley@XXXXXXXX

Sent: Tuesday, March 01, 2011 8:25 AM

Subject: Re: FW: re-Prions David W. Colby1,* and Stanley B. Prusiner1,2 + Author Affiliations

Dear Terry Singeltary,

Thank you for your correspondence regarding the review article Stanley Prusiner and I recently wrote for Cold Spring Harbor Perspectives. Dr. Prusiner asked that I reply to your message due to his busy schedule. We agree that the transmission of CWD prions to beef livestock would be a troubling development and assessing that risk is important. In our article, we cite a peer-reviewed publication reporting confirmed cases of laboratory transmission based on stringent criteria. The less stringent criteria for transmission described in the abstract you refer to lead to the discrepancy between your numbers and ours and thus the interpretation of the transmission rate. We stand by our assessment of the literature--namely that the transmission rate of CWD to bovines appears relatively low, but we recognize that even a low transmission rate could have important implications for public health and we thank you for bringing attention to this matter. Warm Regards, David Colby -- David Colby, PhDAssistant Professor Department of Chemical Engineering University of Delaware

===========END...TSS==============

Thursday, July 03, 2014

How Chronic Wasting Disease is affecting deer population and what’s the risk to humans and pets?

http://chronic-wasting-disease.blogspot.com/2014/07/how-chronic-wasting-disease-is.html



PRION CONFERENCE 2014 HELD IN ITALY RECENTLY CWD BSE TSE UPDATE

> First transmission of CWD to transgenic mice over-expressing bovine prion protein gene (TgSB3985)

PRION 2014 - PRIONS: EPIGENETICS and NEURODEGENERATIVE DISEASES – Shaping up the future of prion research

Animal TSE Workshop 10.40 – 11.05 Talk Dr. L. Cervenakova First transmission of CWD to transgenic mice over-expressing bovine prion protein gene (TgSB3985)

http://www.prion2014.org/images/Animal_TSE_workshop.pdf

P.126: Successful transmission of chronic wasting disease (CWD) into mice over-expressing bovine prion protein (TgSB3985)

Larisa Cervenakova,1 Christina J Sigurdson,2 Pedro Piccardo,3 Oksana Yakovleva,1 Irina Vasilyeva,1 Jorge de Castro,1 Paula Saá,1 and Anton Cervenak1 1American Red Cross, Holland Laboratory; Rockville, MD USA; 2University of California; San Diego, CA USA; 3Lab TSE/OBRR /CBER/FDA; Rockville, MD USA

Keywords: chronic wasting disease, transmission, transgenic mouse, bovine prion protein

Background. CWD is a disease affecting wild and farmraised cervids in North America. Epidemiological studies provide no evidence of CWD transmission to humans. Multiple attempts have failed to infect transgenic mice expressing human PRNP gene with CWD. The extremely low efficiency of PrPCWD to convert normal human PrPC in vitro provides additional evidence that transmission of CWD to humans cannot be easily achieved. However, a concern about the risk of CWD transmission to humans still exists. This study aimed to establish and characterize an experimental model of CWD in TgSB3985 mice with the following attempt of transmission to TgHu mice.

Materials and Methods. TgSB3985 mice and wild-type FVB/ NCrl mice were intracranially injected with 1% brain homogenate from a CWD-infected Tga20 mouse (CWD/Tga20). TgSB3985 and TgRM (over-expressing human PrP) were similarly injected with 5% brain homogenates from CWD-infected white-tailed deer (CWD/WTD) or elk (CWD/Elk). Animals were observed for clinical signs of neurological disease and were euthanized when moribund. Brains and spleens were removed from all mice for PrPCWD detection by Western blotting (WB). A histological analysis of brains from selected animals was performed: brains were scored for the severity of spongiform change, astrogliosis, and PrPCWD deposition in ten brain regions.

Results. Clinical presentation was consistent with TSE. More than 90% of TgSB3985 and wild-type mice infected with CWD/Tga20, tested positive for PrPres in the brain but only mice in the latter group carried PrPCWD in their spleens. We found evidence for co-existence or divergence of two CWD/ Tga20 strains based on biochemical and histological profiles. In TgSB3985 mice infected with CWD-elk or CWD-WTD, no animals tested positive for PrPCWD in the brain or in the spleen by WB. However, on neuropathological examination we found presence of amyloid plaques that stained positive for PrPCWD in three CWD/WTD- and two CWD/Elk-infected TgSB3985 mice. The neuropathologic profiles in CWD/WTD- and CWD/Elkinfected mice were similar but unique as compared to profiles of BSE, BSE-H or CWD/Tg20 agents propagated in TgSB3985 mice. None of CWD-infected TgRM mice tested positive for PrPCWD by WB or by immunohistochemical detection.

Conclusions. To our knowledge, this is the first established experimental model of CWD in TgSB3985. We found evidence for co-existence or divergence of two CWD strains adapted to Tga20 mice and their replication in TgSB3985 mice. Finally, we observed phenotypic differences between cervid-derived CWD and CWD/Tg20 strains upon propagation in TgSB3985 mice. Further studies are underway to characterize these strains.

PRION 2014 CONFERENCE

CHRONIC WASTING DISEASE CWD

A FEW FINDINGS ;

Conclusions. To our knowledge, this is the first established experimental model of CWD in TgSB3985. We found evidence for co-existence or divergence of two CWD strains adapted to Tga20 mice and their replication in TgSB3985 mice. Finally, we observed phenotypic differences between cervid-derived CWD and CWD/Tg20 strains upon propagation in TgSB3985 mice. Further studies are underway to characterize these strains.

We conclude that TSE infectivity is likely to survive burial for long time periods with minimal loss of infectivity and limited movement from the original burial site. However PMCA results have shown that there is the potential for rainwater to elute TSE related material from soil which could lead to the contamination of a wider area. These experiments reinforce the importance of risk assessment when disposing of TSE risk materials.

The results show that even highly diluted PrPSc can bind efficiently to polypropylene, stainless steel, glass, wood and stone and propagate the conversion of normal prion protein. For in vivo experiments, hamsters were ic injected with implants incubated in 1% 263K-infected brain homogenate. Hamsters, inoculated with 263K-contaminated implants of all groups, developed typical signs of prion disease, whereas control animals inoculated with non-contaminated materials did not.

Our data establish that meadow voles are permissive to CWD via peripheral exposure route, suggesting they could serve as an environmental reservoir for CWD. Additionally, our data are consistent with the hypothesis that at least two strains of CWD circulate in naturally-infected cervid populations and provide evidence that meadow voles are a useful tool for CWD strain typing.

Conclusion. CWD prions are shed in saliva and urine of infected deer as early as 3 months post infection and throughout the subsequent >1.5 year course of infection. In current work we are examining the relationship of prionemia to excretion and the impact of excreted prion binding to surfaces and particulates in the environment.

Conclusion. CWD prions (as inferred by prion seeding activity by RT-QuIC) are shed in urine of infected deer as early as 6 months post inoculation and throughout the subsequent disease course. Further studies are in progress refining the real-time urinary prion assay sensitivity and we are examining more closely the excretion time frame, magnitude, and sample variables in relationship to inoculation route and prionemia in naturally and experimentally CWD-infected cervids.

Conclusions. Our results suggested that the odds of infection for CWD is likely controlled by areas that congregate deer thus increasing direct transmission (deer-to-deer interactions) or indirect transmission (deer-to-environment) by sharing or depositing infectious prion proteins in these preferred habitats. Epidemiology of CWD in the eastern U.S. is likely controlled by separate factors than found in the Midwestern and endemic areas for CWD and can assist in performing more efficient surveillance efforts for the region.

Conclusions. During the pre-symptomatic stage of CWD infection and throughout the course of disease deer may be shedding multiple LD50 doses per day in their saliva. CWD prion shedding through saliva and excreta may account for the unprecedented spread of this prion disease in nature.

P.28: Modeling prion species barriers and the new host effect using RT-QuIC

Kristen A Davenport, Davin M Henderson, Candace K Mathiason, and Edward A Hoover Prion Research Center; Colorado State University; Fort Collins, CO USA

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious.

Studies of the effects of primary or tertiary prion protein www.landesbioscience.com Prion 37 structures on trans-species prion transmission have relied upon animal bioassays, making the influence of prion protein structure vs. host co-factors (e.g. cellular constituents, trafficking, and innate immune interactions) difficult to dissect.

As an alternative strategy, we are using real-time quaking-induced conversion (RT-QuIC) to investigate the propensity for and the kinetics of trans-species prion conversion. RT-QuIC has the advantage of providing more defined conditions of seeded conversion to study the specific role of native PrP:PrPRES interactions as a component of the species barrier.

We are comparing chronic wasting disease (CWD) and bovine spongiform encephalopathy (BSE) prions by seeding each prion into its native host recPrP (full-length bovine recPrP, or white tail deer recPrP) vs. into the heterologous species.

Upon establishing the characteristics of intra-species and inter-species prion seeding for CWD and BSE prions, we will evaluate the seeding kinetics and cross-species seeding efficiencies of BSE and CWD passaged into a common new host—feline—shown to be a permissive host for both CWD and BSE.

*** We hypothesize that both BSE prions and CWD prions passaged through felines will seed human recPrP more efficiently than BSE or CWD from the original hosts, evidence that the new host will dampen the species barrier between humans and BSE or CWD. The new host effect is particularly relevant as we investigate potential means of trans-species transmission of prion disease.

https://www.landesbioscience.com/journal...d%20Biology.pdf

Chronic Wasting Disease Susceptibility of Four North American Rodents

Chad J. Johnson1*, Jay R. Schneider2, Christopher J. Johnson2, Natalie A. Mickelsen2, Julia A. Langenberg3, Philip N. Bochsler4, Delwyn P. Keane4, Daniel J. Barr4, and Dennis M. Heisey2 1University of Wisconsin School of Veterinary Medicine, Department of Comparative Biosciences, 1656 Linden Drive, Madison WI 53706, USA 2US Geological Survey, National Wildlife Health Center, 6006 Schroeder Road, Madison WI 53711, USA 3Wisconsin Department of Natural Resources, 101 South Webster Street, Madison WI 53703, USA 4Wisconsin Veterinary Diagnostic Lab, 445 Easterday Lane, Madison WI 53706, USA *Corresponding author email: cjohnson@svm.vetmed.wisc.edu

We intracerebrally challenged four species of native North American rodents that inhabit locations undergoing cervid chronic wasting disease (CWD) epidemics. The species were: deer mice (Peromyscus maniculatus), white-footed mice (P. leucopus), meadow voles (Microtus pennsylvanicus), and red-backed voles (Myodes gapperi). The inocula were prepared from the brains of hunter-harvested white-tailed deer from Wisconsin that tested positive for CWD. Meadow voles proved to be most susceptible, with a median incubation period of 272 days. Immunoblotting and immunohistochemistry confirmed the presence of PrPd in the brains of all challenged meadow voles. Subsequent passages in meadow voles lead to a significant reduction in incubation period. The disease progression in red-backed voles, which are very closely related to the European bank vole (M. glareolus) which have been demonstrated to be sensitive to a number of TSEs, was slower than in meadow voles with a median incubation period of 351 days. We sequenced the meadow vole and red-backed vole Prnp genes and found three amino acid (AA) differences outside of the signal and GPI anchor sequences. Of these differences (T56-, G90S, S170N; read-backed vole:meadow vole), S170N is particularly intriguing due its postulated involvement in "rigid loop" structure and CWD susceptibility. Deer mice did not exhibit disease signs until nearly 1.5 years post-inoculation, but appear to be exhibiting a high degree of disease penetrance. White-footed mice have an even longer incubation period but are also showing high penetrance. Second passage experiments show significant shortening of incubation periods. Meadow voles in particular appear to be interesting lab models for CWD. These rodents scavenge carrion, and are an important food source for many predator species. Furthermore, these rodents enter human and domestic livestock food chains by accidental inclusion in grain and forage. Further investigation of these species as potential hosts, bridge species, and reservoirs of CWD is required.

http://chronic-wasting-disease.blogspot.com/2009/08/third-international-cwd-symposium-july.html


please see ;

http://www.cwd-info.org/pdf/3rd_CWD_Symposium_utah.pdf


http://chronic-wasting-disease.blogspot.com/


terry

Re: CWD in Texas [Re: Frio County Hunts] #5822891 07/08/15 04:01 PM
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Kristen A Davenport, Davin M Henderson, Candace K Mathiason, and Edward A Hoover Prion Research Center; Colorado State University; Fort Collins, CO USA

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious.

Studies of the effects of primary or tertiary prion protein www.landesbioscience.com Prion 37 structures on trans-species prion transmission have relied upon animal bioassays, making the influence of prion protein structure vs. host co-factors (e.g. cellular constituents, trafficking, and innate immune interactions) difficult to dissect.

As an alternative strategy, we are using real-time quaking-induced conversion (RT-QuIC) to investigate the propensity for and the kinetics
of trans-species prion conversion. RT-QuIC has the advantage of providing more defined conditions of seeded conversion to study the specific role of native PrP:PrPRES interactions as a component of the species barrier.

We are comparing chronic wasting disease (CWD) and bovine spongiform encephalopathy (BSE) prions by seeding each prion into its native host recPrP (full-length bovine recPrP, or white tail deer recPrP) vs. into the heterologous species.

Upon establishing the characteristics of intra-species and inter-species prion seeding for CWD and BSE prions, we will evaluate the seeding kinetics and cross-species seeding efficiencies of BSE and CWD passaged into a common new host—feline—shown to be a permissive host for both CWD and BSE.


*** We hypothesize that both BSE prions and CWD prions passaged through felines will seed human recPrP more efficiently than BSE or CWD from the original hosts, evidence that the new host will dampen the species barrier between humans and BSE or CWD. The new host effect is particularly relevant as we investigate potential means of trans-species transmission of prion disease.

I assume this is an ongoing study. It's an important one because it seeks to replicate the process that produced vCJD and is the potential path for CWD to breach the species barrier. It should help quantify the real danger of CWD crossing the trans species barrier.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: Frio County Hunts] #5822894 07/08/15 04:02 PM
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In one ear and out the other sleep



Re: CWD in Texas [Re: nsmike] #5822926 07/08/15 04:21 PM
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Folks, just because pathogens share similar transmission vectors does not mean that the pathogen is going to somehow jump species barriers that are in place.

Canine distemper and the flu's have been around for centuries. Flu's effect people as well as canines. But we don't get distemper.

Now, can someone in a lab conjure up some gene combination that would never occur in nature to provide a means of trans specie transmission? Maybe.

But that's not what this thread was supposed to be about. back


Crotchety old bastidge
Re: CWD in Texas [Re: titan2232] #5823046 07/08/15 05:45 PM
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Originally Posted By: titan2232
In one ear and out the other sleep


x2

Re: CWD in Texas [Re: Frio County Hunts] #5823191 07/08/15 07:14 PM
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Wouldn't properly cooking your venison take care of this problem? If you think about it for half a second, there's no telling what hunters have ingested over the years from wild game. I'll take my chances still.

Re: CWD in Texas [Re: jmh004] #5823212 07/08/15 07:34 PM
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Originally Posted By: jmh004
Wouldn't properly cooking your venison take care of this problem? If you think about it for half a second, there's no telling what hunters have ingested over the years from wild game. I'll take my chances still.


No, it's someone like 900 degrees for 4hours... But is it actually a problem



Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5825073 07/09/15 10:25 PM
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Looks like this topic has lost its steam.

Re: CWD in Texas [Re: jmh004] #5825416 07/10/15 02:34 AM
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It's just the lull before the storm. TPWD is designing a strategy that (if rumors are true) will include not only killing all deer in the pen the buck came from, but all pens on the ranch. Even though they are separated by a 30' alley and have never co-mingled. After that, they do have designs on going after all ranches that have had transfers of breeder deer from that ranch (47 is the last number I've heard). Not stocker deer from what I hear, but deer that were put into pens for breeding in licensed breeding facilities.

Also, it's rumored (two different sources) that they have told the landowner that not only can he not take pictures or video the slaughter, but that he can't even be on his own ranch during the slaughter.

I hope that the last rumor above isn't true. For the state's sake. I can assure you it will cost the state more than it can imagine if they try that.

Thank God we've got all the irrelevant links out of the way. Hopefully we can focus on what the test results are from the deer, and use this thread to share relevant information about how the state proceeds.


Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5825437 07/10/15 02:49 AM
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I'd be working on a federal injunction ASAP. That's some BS. I've heard similar. Something don't smell right and it ain't on the private land owner this time.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5825489 07/10/15 03:23 AM
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I have heard the same about the owner. Also some other things that are very disturbing if true.


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Re: CWD in Texas [Re: Frio County Hunts] #5825499 07/10/15 03:29 AM
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CWD in Texas now.......thanks a lot Obama


For it is not the quarry that we truly seek, but the adventure.
Re: CWD in Texas [Re: therancher] #5825500 07/10/15 03:30 AM
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Originally Posted By: therancher

Thank God we've got all the irrelevant links out of the way. Hopefully we can focus on what the test results are from the deer, and use this thread to share relevant information about how the state proceeds.


X100

Re: CWD in Texas [Re: BOBO the Clown] #5825592 07/10/15 04:48 AM
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Originally Posted By: BOBO the Clown
I'd be working on a federal injunction ASAP. That's some BS. I've heard similar. Something don't smell right and it ain't on the private land owner this time.


Yep, according to all that I'm hearing, the owner has crossed all t's and dotted all i's. Volunteered his animals for research, but the state is flat out going in to destroy the herd to prevent research! No reason for the state to do that OR to bully this guy.

From what I hear he's just bending over. We need him to fight.


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Re: CWD in Texas [Re: Frio County Hunts] #5825595 07/10/15 04:52 AM
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It really bothers me that they will not allow researchers to take samples prior to destroying the herd. How can you learn about it if you don't allow research?


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: nsmike] #5825714 07/10/15 12:36 PM
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Originally Posted By: nsmike
It really bothers me that they will not allow researchers to take samples prior to destroying the herd. How can you learn about it if you don't allow research?


Not just that.... Tons of ranches that bought deer from that ranch have offered those deer up for research.... TPWD reply not right now..... Why?

popcorn Somebody has an alternative motive... This ain't stoping at one ranch.....


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOBO the Clown] #5825925 07/10/15 02:40 PM
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Originally Posted By: BOBO the Clown
Originally Posted By: nsmike
It really bothers me that they will not allow researchers to take samples prior to destroying the herd. How can you learn about it if you don't allow research?


Not just that.... Tons of ranches that bought deer from that ranch have offered those deer up for research.... TPWD reply not right now..... Why?

popcorn Somebody has an alternative motive... This ain't stoping at one ranch.....


When you read CWD research one continous theme is that their confidence level is low because of limited samples. It's a catch 22, the researchers don't have enough samples to make real progress, yet when it's identified in a captive herd they're not allowed to take samples.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: Frio County Hunts] #5826215 07/10/15 06:12 PM
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Since the vast majority of deer (if not all) about to be slaughtered will test negative for CWD, is the state going to do the right thing and donate the meat to the needy???


Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5826247 07/10/15 06:31 PM
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Cannot be present on their own land? Is this Texas or Communist Russia? There's no way that's legal. The government can't just throw someone off private property for an amount of time. There were no laws that were broken. I'm sure that ranch's lawyer is about to go to town on that one.

Re: CWD in Texas [Re: jmh004] #5826375 07/10/15 07:48 PM
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Originally Posted By: jmh004
Cannot be present on their own land? Is this Texas or Communist Russia? There's no way that's legal. The government can't just throw someone off private property for an amount of time. There were no laws that were broken. I'm sure that ranch's lawyer is about to go to town on that one.


I agree it sounds too far fetched. And it might be a BS rumor. I'm doing my best to get it confirmed or quashed.


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Re: CWD in Texas [Re: therancher] #5826380 07/10/15 07:50 PM
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Exotic Wildlife Association
Membership Alert


TAHC
Chronic Wasting Disease (CWD) Herd Plan for
Trace-Forward Exposed Herd with Testing of Exposed Animals
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* A trace-forward exposed herd is a herd that has received an animal from a CWD-positive herd within 5 years before the diagnosis of CWD in the positive herd

* Texas Animal Health Commission (TAHC) will issue trace-forward exposed herds a hold order restricting movement of all CWD susceptible species pending an epidemiological investigation by TAHC.

* Note: This plan is subject to modification based on new epidemiological information.

1. All trace-forward exposed animals traced to a herd, regardless of their participation in the TAHC Herd Status Program for Cervidae, should be removed and tested:

* If the animal tested CWD-positive, the herd is considered to be positive and handled using a CWD-positive herd plan.

* If the animal tested "not detected", the TAHC Hold Order may be released. Herds in the TAHC Herd Status Program for Cervidae may have their status restored. Texas Parks and Wildlife Department (TPWD) may have additional requirements to regain "Movement Qualified Status."

2. For trace-forward exposed herds that are participants in the TAHC Herd Status Program for Cervidae shall immediately be placed in Suspended status pending an epidemiological investigation by TAHC.

* If the epidemiological investigation determines that the herd was not commingled with an animal from the CWD-positive herd, the herd will be reinstated to its former status, and the time spent in Suspended status be counted in its herd status.

* Animals are commingled if they have direct contact with each other, have less than 10 feet of physical separation, or share equipment, pasture, or water sources/watershed.

* If the epidemiological investigation determines that the herd was commingled with an animal from the CWD-positive herd, the herd will lose its program status and be designated a CWD-exposed herd. Herd status may be restored if the trace-forward exposed animal(s) is tested "not detected" for CWD.

3. The CWD postmortem testing of trace-forward exposed animals will be performed at the Texas Veterinary Medical Laboratory (TVMDL) in College Station, TX.

* Subject to the availability of funds, the testing of trace-forward exposed animals will be provided by the TAHC. Shipping costs shall be borne by the facility owner.

* Please note: the TVMDL submission form must state "The specimen is from a CWD exposed animal epidemiologically linked to a CWD positive herd." This statement will ensure the testing is appropriately charged to the TAHC.

4. Both obex and medial retropharyngeal lymph nodes in 10% formalin collected from trace-forward exposed animals are required to be tested for CWD. All animal identification (ear tags, tattoos, etc.) shall be submitted with the entire ear attached fresh or frozen, and must be recorded on the corresponding TVMDL submission form. Diagnostic specimens shall be submitted to TVMDL using one of the following procedures and individuals listed below.

* A USDA accredited, TAHC authorized, CWD certified veterinarian can either collect and submit the above specimens in 10% formalin or submit a whole head to TVMDL.

* The facility owner can only submit a whole head to TVMDL.

* A USDA, TAHC, or TPWD regulatory official can either collect and submit the above specimens in 10% formalin or submit a whole head to TVMDL.

5. Prior to the harvest and testing of trace-forward exposed animals that have been liberated to the wild, the property owner must call TPWD Central Dispatch at 512-389-4848 to request authorization. No liberated deer can be harvested during a closed season without prior approval by TPWD.

* Testing and sample submission requirements in Section 4 are applicable.

6. If an exposed animal traced to a herd has died and was not tested for CWD, no longer resides in the herd, cannot be identified, or is otherwise unavailable for testing, a risk evaluation will be conducted to determine the level of CWD risk associated with the length of time the exposed animal was held in trace facilities. This may include a review of all aspects of the producer's management, compliance, and record keeping to determine how best to manage each exposed herd. A herd plan will be established to describe required surveillance activities and management practices. All CWD susceptible species in exposed herds will be put under a TAHC hold order pending CWD test results and epidemiological assessment.
Charly Seale
Executive Director
Exotic Wildlife Association
Mobile-830-928-3158
charly@myewa.org











Exotic Wildlife Association | 105 Henderson Branch Rd W | Ingram | TX | 78025


Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5826407 07/10/15 08:08 PM
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Ok. I just verified (with the landowner) that what we are hearing is true. The state is telling them they can't be present when the deer are killed and that they won't allow it to be filmed.

They are working with legal council and hopefully the state will grow a brain before this gets crazy.

The other rumors about offering the animals for research are all true too.

These folks need the help of the entire industry.


Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5826498 07/10/15 09:11 PM
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I'm no legal expert, but that has to be unconstitutional. Not allow to film or even be on your own property? Who knows what the heck those people could be doing out there with no witnesses. Put CWD aside, this is just flat out wrong.

Re: CWD in Texas [Re: jmh004] #5828400 07/12/15 02:49 PM
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Originally Posted By: jmh004
I'm no legal expert, but that has to be unconstitutional. Not allow to film or even be on your own property? Who knows what the heck those people could be doing out there with no witnesses. Put CWD aside, this is just flat out wrong.



I said the same thing years ago, 'what are these folks capable of doing'?


so, let me show you, from my experience.

now, before going there, remember what our fine federal friends did with tobacco and asbestos. they covered that up for 100 years, and lied to us.


I am reminded of another similar incident. the mad sheep of mad river valley. what a mess that was. now that was all politics. a mistake made by government officials to let the damn sheep in to begin with, when they knew there was an atypical BSE case in Belgium, but they let them in anyway, and then had to back peddle fast. the owners took the blunt of that blunder, but were well paid for it afterward. I fought that case for 10 years via FOIA's, and the producer of the film even sent me the script to proof read for them. I did not agree with the science they were going by, and it _has_ been proven wrong since then, as I told them. but their plight was indeed a disturbing one. I felt for them, their family, their animals, and the Gestapo type tactics that followed.

in short, a decade or so ago, a family with exotic sheep that made cheese imported from Belgium to the USA, some exotic Belgium sheep. right afterward, it was discovered that these sheep should have never been allowed to come to the USA, but they were already here. all this became suspicious to me, so i begin my FOIA's request way back around 2000 or 2001. I believe a plan was put forth to find some suspect cases of TSE prion disease in those sheep. at first, it was stated that they tested some of these sheep and they came up positive with an atypical type TSE. this is what they based their scorched earth policy on, and scorch it they did. but the only problem was, those sheep never had any TSE prion disease, and the feds _knew it all along_. this was a sad story indeed. all the way around. but this is the TSE prion disease and politics at it's worst. what we already know about TSE prion disease is scariest enough, it's what they don't know that scares them so bad.

now I know everyone of these pen owners here are going to jump all over this. but it needs to be told here, this is the other side of this nightmare. it will not end soon. too much money involved, and enough stupid to go around for everyone.

here is this story of 'the mad sheep of mad river valley', the sheep that never were mad, and testing was _manipulated_ by the government...I'm just saying!


I'm going to get a bit long winded again, but this is for your files, if anyone is keeping any. I might disappear some day and good or bad, I want this stuff filed away...terry




From: Terry S. Singeltary Sr.
Sent: Friday, February 20, 2015 12:25 PM
To: BSE-L@LISTS.AEGEE.ORG
Subject: [BSE-L] APHIS Freedom of Information Act (FOIA) Appeal Mouse Bio-Assays 2007-00030-A Sheep Imported From Belgium and the Presence of TSE Prion Disease Kevin Shea to Singeltary 2015

APHIS Freedom of Information Act (FOIA) Appeal Mouse Bio-Assays 2007-00030-A Sheep Imported From Belgium and the Presence of TSE Prion Disease Kevin Shea to Singeltary 2015


Greetings BSE-L Members et al,

you can’t believe what I got in the US Postal mail today. the wife would not pick it up yesterday, because there was a $6.00 charge for a certified letter from USDA Kevin Shea for about 5 pages. I went to the PO today, told the girls in the back that if it’s an affidavit, a warrant, summons, I don’t want it, send it back. but it was certified. scared me. but the curiosity got to me, so i coughed up 6 bucks, and took a chance. low and behold, after my last appeal to this decade plus old quest was turned down, even though I already had the answer from another source, APHIS et al finally stumbled across those old mouse bio-assays. they had them all along.

what the industry sent me first was better, because it had some of the good stuff i.e. redacted.

this all started way back around the year 2,000, when in my opinion, the USDA et al let these sheep in the USA from Belgium, when they should not have because of atypical BSE in Belgium. I started asking for the these mouse bio-assays back in or around 2003 or before, then I had to get official with FOIA, because no one would answer my questions.

well, it’s February 20, 2015, over a decade later, and I don’t know how many denials, here’s what was in the mail yesterday, February 19, 2015 ;

United States Department of Agriculture

Animal and Plant Health Inspection Service Marketing and Regulatory Programs Animal and Plant Health Inspection Service Legislative and Public Affairs Freedom of Information 4700 River Road Unit 50 Riverdale, MD. 20737-1232

FEB 10 2015

Terry S. Singletary Sr. P.O. Box 42 Bacliff, Texas 77518

Re: FOIA Appeal # 2007-00030-A

Dear Mr. Singletary:

This letter is in response to the Freedom of Information Act (FOIA) appeal that you submitted regarding FOIA request 07-566. Your appeal challenged the APHIS FOIA Office's search for the "Mouse Bio-Assays" on the sheep imported from Belgium. We apologize for the delayed response.

The APHIS FOIA Office received your appeal, on July 7, 2007 and assigned it FOIA case number 2007-00030-A.

In response to your appeal, the APHIS FOIA Office performed a second search of records responsive to your initial request. The Agency has since found four (4) pages of responsive records for the "Mouse Bio-Assays" dated October 22,2009. Although these records postdate both your initial request and subsequent appeal by approximately two years; we enclose them in the interest of responsiveness to your request.

We now consider this appeal closed and will take no further action. If you are dissatisfied with this decision, you have the right to judicial review in an appropriate United States District Court in accordance with 5 U.S.C. 552, (2)(4)(B).

Prior to seeking judicial review, you may contact the Office of Government Information Services (OGlS). OGIS was created within the National Archives and Records Administration when the Open Government Act of 2007 amended the FOIA. OGIS provides mediation of FOIA disputes between appellants and federal agencies. Participation in mediation does not affect your right to judicial review. Contact information for OGIS can be found at http:/www.archives.gov/ogis.

Sincerely,

Kevin Shea Administrator Enclosure

snip...end

the next 4 pages is exactly what I received from an industry source way back on Saturday, February 27, 2010. see ;

Saturday, February 27, 2010

FINAL REPORT OF THE TESTING OF THE BELGIAN (VERMONT) SHEEP

February 27, 2010

http://foiamadsheepmadrivervalley.blogspot.com/2010/02/final-report-of-testing-of-belgian.html


see history below ;


From: Terry S. Singeltary Sr.

Sent: Thursday, February 19, 2015 10:04 PM

To: Terry S. Singeltary Sr. Subject: mad sheep mad river valley...NOT...never was

Veterinary Laboratories Agency – Weybridge

New Haw, Addlestone, Surrey KT15 3NB United Kingdom

Telephone +44 (0)1932 341111 Facsimile +44 (0)1932 347046 '

Web site http://www.vla.gov.uk

Veterinary Laboratories Agency

Your ref: MPL-6197-7-37

Our ref: FT1294

This is the FINAL report for contract MPL-6197-7-37 The testing of the Belgian (Vermont) sheep.

Background

Brain homogenate (10% in normal saline) from each case was inoculated intracerebralty into panels of 20 Rlll and 20 Tg338 mice.

FT1294/0001 (Sample 4677) was inoculated into mice on the 14/12/06

FT1294/0011 (Sample 4703) was inoculated into mice on the 20/12/06

Method

The brain from each mouse was examined histologically for any evidence of TSE-related vacuolation, and immunolabelled using anti-PrP antibody Rb486 as described elsewhere1, All slide interpretation was undertaken blind with regard to the clinical status of the mouse, or the source of the inoculum.

Final bioassay results

FT1294/0001 (Sample 4677)

Tg338 mice - All 20 mice are negative by histopathology, and immunohistochemistry

Rlll mice - All 20 mice are negative negative by histopathology, and immunohistochemistry

FT1294/0011 (Sample 4703)

Tg338 mice - All 20 mice are negative by histopathology, and immunohistochemistry

Rlll mice - All 20 mice are negative by histopathology, and immunohrstochernistry

The survival times for these mice can be seen in the figures below. Additional data sets from positive and negative inocula (J Spiropoulos, pers. comm.) have been included for comparison._

1 Beck KE, Chaplin M, Stack M: Sallis RE, Simonini S, Lockey R, Spiropoulos J. Lesion Profiling at Primary Isolation in Rlll Mice Is Insufficient in Distinguishing BSE from Classical Scrapie. Brain Pathol. 2009 epub ahead of print

FINAL report for contract MPL-6197-7-37

VLA is an Executive Agency of the Department for Environment, Food and Rural Affairs (Defra)

snip... (2 pages of charts and graphs of survival and comparison of tg338 data NOT included here...TSS)

CONCLUSION

These mice have survived for long enough to have demonstrated the presence of classical scrapie, atypical scrapie, or ovine BSE if any of these strains was present in the inoculum.

Both samples are negative by bioassay.

Dr. Marion M Simmons

22nd October 2009

February 27, 2010, INVESTIGATION OF MAD SHEEP OF MAD RIVER VALLEY COMPLETE. THEY WERE NOT INFECTED WITH ANY TSE. ...TSS

Greetings again BSE list members,

The investigation of the Mad Sheep of Mad River Valley may be complete now, but, I still have questions.

PLEASE SEE MY FINAL FOIA HERE ;

Monday, September 1, 2008

RE-FOIA OF DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. (PRION DISEASE) OF FOREIGN ORIGIN IN THE UNITED STATES [No. 00-072-1] September 1, 2008

Greetings again BSE-L members,

I had a pleasant surprise this past Saturday. I got an unexpected package from O.I.G. on my old F.O.I.A. request, of the final test results of the infamous mad sheep of mad river valley. IF you all remember, back on Thu, 24 Apr 2008 15:00:20 -0500 I wrote ;

Greetings,

With great disgust, I must report, that after years and years of wrangling over the infamous mad sheep of mad river valley, I have failed in getting an official answer via FOIA on the outcome of the TSE testing of those imported Belgium sheep. The USA Government refuses to tell the public, exactly what the testing outcome was, and in doing so, shows just how corrupt this administration has been. and the excuse given in their answer to my final appeal, which they have now officially denied, was bizarre to say the least ;

"I am denying your FOIA appeal. This is the final agency decision. You may seek judicial review of this decision in the United States district court for the judicial district in which you reside or have your principal place of business or in the District of Columbia, pursuant to 5 U.S.C. & 552(a)(4)(B)."

FOIA OF DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. (PRION DISEASE) OF FOREIGN ORIGIN IN THE UNITED STATES [Docket No. 00-072-1] ...snip...end...TSS

NOW, out of the wild blue, AFTER them telling me they denied my FOIA appeal for the final time, any further action would have to be judicial review in the United States district court, I get 25+ pages, a lot of redacted names, etc, but this is the first time they sent me anything about this in the 6 years of waiting for my FOIA request. IT will take me a long time to get this online due to the fact you cannot hardly read it, very poor quality and eligibility of text. BUT, the just of it is, somebody (REDACTED) screwed those tests up. I will work to get all the data online next week or so, but it is odd how much they were concerned for human and animal health from an atypical scrapie of foreign origin back then, but yet when we document it here in the USA, you don't hear a word about it. it's a completely different story.

IN SHORT ;

August 15, 2000

OIG case # NY-3399-56 REDACTED, VT

''Enclosed is OIG's notification that they have scheduled an investigation of the following individual. REDACTED is alleged to have provided possibly inaccurate test results involving diseased sheep. However, because the results were determined to be inconclusive, no actual violation was actually committed.''

snip...

IN SHORT ;

August 15, 2000

OIG case # NY-3399-56 REDACTED, VT

''Enclosed is OIG's notification that they have scheduled an investigation of the following individual. REDACTED is alleged to have provided possibly inaccurate test results involving diseased sheep. However, because the results were determined to be inconclusive, no actual violation was actually committed.''

snip...

[only bush et al could have interpreted it that way. don't all criminals wish this is the way the system worked. ...tss]

JULY, 28, 2000

Case Opening Memorandum

snip...

An investigation regarding the subject identified below will be conduced and a report submitted at the conclusion of the investigation. If you have or should later receive additional information concerning this matter, please forward it to this office.

If you believe that administrative action should be taken before all criminal and other legal matters are completed, please coordinate that action with this office in order not to jeopardize the ongoing investigation.

The fact that this subject is under investigation should not be discussed with anyone who does not have a need to know and all inquiries on the investigation should be referred to the office of Inspector General.

snip...end

FOR OFFICIAL USE ONLY FEBRUARY 7, 2002

SUBJECT OIG CASE NY-3399-56 REDACTED VT HEALTH/SANITATION VIOLATION

TO: William Buisch, Regional Director Eastern Region, VS Raleigh, NC

Enclosed is the official investigation report on REDACTED. If you will recall, REDACTED is alleged to have provided possible inaccurate test results involving diseased sheep.

OIG is closing their file upon issuance of the Report of Investigation (copy enclosed). We are, therefore, also closing our case file.

REDACTED

Resource Management Systems and Evaluation Staff

Enclosure

cc:

REDACTED IES, Riverdale, MD (w/cy of incoming)

APHIS:RMSES: REDACTED 2/7/02 "NY-3399-56-REDACTED Closure''

END...TSS

NOW, the question is, who screwed those test up, and was it done on purpose, just to cover someone's [censored] for letting those sheep in here in the first place ???

WHICH tests were compromised, one of them, all of them, and, can we trust the outcome of any of these test under the circumstances here ???

i.e.

"It is significant that four of the sheep which first tested positive on REDACTED Western blot tests, thereby providing the type of confirmation the plaintiffs argue is lacking on the current record."

UNDER what circumstances were these test compromised ???

MY basic, simple question, was not answered in layman term, i.e. exactly what strain of TSE did those sheep have ???

IS this the best we can do ???

>>>"REDACTED is alleged to have provided possibly inaccurate test results involving diseased sheep. However, because the results were determined to be inconclusive, no actual violation was actually committed.''<<<

PLEASE SEE FULL TEXT HERE ;

http://foiamadsheepmadrivervalley.blogspot.com/2010/02/final-report-of-testing-of-belgian.html

Saturday, February 27, 2010

*** FINAL REPORT OF THE TESTING OF THE BELGIAN (VERMONT) SHEEP February 27, 2010 IN SHORT ; August 15, 2000 OIG case # NY-3399-56 REDACTED, VT ''Enclosed is OIG's notification that they have scheduled an investigation of the following individual. REDACTED is alleged to have provided possibly inaccurate test results involving diseased sheep. However, because the results were determined to be inconclusive, no actual violation was actually committed.''

FINAL REPORT OF THE TESTING OF THE BELGIAN (VERMONT) SHEEP February 27, 2010

(10 YEARS LATER, FOIA, none of the sheep had any TSE at all...tss)

http://foiamadsheepmadrivervalley.blogspot.com/2010/02/final-report-of-testing-of-belgian.html

Thursday, April 24, 2008

RE-FOIA OF DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. OF FOREIGN ORIGIN IN THE UNITED STATES [Docket No. 00-072-1]

http://foiamadsheepmadrivervalley.blogspot.com/2008/04/re-foia-of-declaration-of-extraordinary.html

Monday, September 1, 2008 RE-FOIA OF DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. (PRION DISEASE) OF FOREIGN ORIGIN IN THE UNITED STATES [No. 00-072-1]

http://foiamadsheepmadrivervalley.blogspot.com/2008/09/re-foia-of-declaration-of-extraordinary.html

FOIA MAD SHEEP MAD RIVER VALLEY

Tuesday, November 13, 2007

DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. (PRION DISEASE) OF FOREIGN ORIGIN IN THE UNITED STATES [Docket No. 00-072-1]

To: Garfield.O.Daley@aphis.usda.gov

CC: phyllis.Fong@usda.gov; bse-L@aegee.org;

Re: FOIA APPEAL 07-566 DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. (PRION DISEASE) OF FOREIGN ORIGIN IN THE UNITED STATES [Docket No. 00-072-1]

November 13, 2007

Greetings Garfield O. Daley, Acting FOIA Director, and USDA et al,

SNIP

for those interested, please see full text answer below received from USDA et al below on latest appeal ;

http://foiamadsheepmadrivervalley.blogspot.com/2007/11/declaration-of-extraordinary-emergency.html

http://foiamadsheepmadrivervalley.blogspot.com/

http://scrapie-usa.blogspot.com/2009_01_01_archive.html


6. WHAT happened to the test results and MOUSE BIO-ASSAYS of those


> imported sheep from Belgium that were confiscated and slaughtered from the

> Faillace's, what sort of TSE did these animals have ? Imported

> Belgium/Netherlands Sheep Test Results Background Factsheet Veterinary

> Services April 2002 APHIS ...snip...

>

> 7. WHY is it that the Farm of the Mad Sheep of Mad River Valley were

> quarantined for 5 years, but none of these farms from Texas and Alabama

> with Atypical TSE in the Bovine, they have not been quarantined for 5

> years, why not, with the real risk of BSE to sheep, whom is to say this

> was not BSE ? (see later results via FOIA below...TSS)...snip



http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf


From: TSS (216-119-138-157.ipset18.wt.net)
Subject: Re: More on the Mad Sheep from Mad River Valley
Date: August 12, 2000 at 8:44 am PST

In Reply to: More on the Mad Sheep from Mad River Valley posted by Terry S. Singeltary Sr. on August 12, 2000 at 8:42 am:

######### Bovine Spongiform Encephalopathy #########

>BSE-suspected Vermont Sheep Get Another
>Reprieve, USDA Backs Off Slaughter Order
>
>BURLINGTON, Vt., August 10 (United Press International) -- Two
>flocks of exotic sheep scheduled for slaughter this week in Vermont
>because of fears some of the animals might be infected with a form
>of the deadly mad cow disease have won yet another reprieve.
>
>The U.S. Department of Agriculture has temporarily backed off plans
>to seize and destroy the animals, the Burlington Free Press reported
>Thursday.
>

Actually something else happened in the interim:


Vermont sheep still grazing as lawyers reach deal


Thu, Aug 10, 2000 Reuters


BURLINGTON, Vt., Aug 10 (Reuters) - Lawyers for owners of Vermont sheep
suspected of having a neurological ailment similar to mad cow disease
struck a deal with prosecutors on Thursday for a fuller court hearing on
the animals' fate.


Under the agreement, lawyers for the farmers will forgo afederal
appeals case in return for a more detailed hearing
Under the agreement, lawyers for the farmers will forgo afederal
appeals case in return for a more detailed hearing in a lower court, said
Tom Amidon, who represents sheep farmer Houghton Freeman.
"So the sheep are on the farm awhile," Amidon said. He hoped a new
hearing would allow for closer examination of claims by the U.S.
Agriculture Department, which wants to seize and eliminate the 350 sheep
under scrutiny as a health precaution.


U.S. District Judge Garvan Murtha ruled last week the Agriculture
Department could carry out its plan. But the farmers planned to appeal
before Thursday's agreement changed the legal picture.
"We will drop our appeal to the second circuit and in return the U.S.
attorneys office in Vermont will allow us to hold a fuller court hearing,"
Amidon said.


Four sheep on Vermont farms near Warren, Vermont, tested positive last
month for a disease known as TSE or transmissible spongiform
encephalopathy, according to USDA officials.


TSE can cause scrapie, a fatal disease in sheep. It is also part of a
family of diseases that includes deadly BSE, also known as bovine
spongiform encephalopathy or mad cow disease.


No cases of BSE or mad cow disease have ever been found in the United
States, but the human form of the disease is blamed for 75 deaths in
Britain during the 1980s.


Breeding pairs for the two flocks of diary sheep came from Belgium and
the Netherlands in the mid-90s.


Amidon said the Belgian government has sent a letter to the USDA
requesting the return of all 350 sheep and that Freeman had already lined
up a plane to transport them. Whether that will eventually occur remains

############ http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html ############


tss

Re: CWD in Texas [Re: flounder] #5828421 07/12/15 03:11 PM
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Mr. Flounder, I'm concerned for your health.

You just posted that there were no positives in the mouse study... as proof that all prion related diseases are something for us all to be terrified of.

You also just used an example that (in your mind, which seems pretty far from reality right now) is related to the current cwd issue. I can assure you it is the opposite.

In your example the govt. was immagined to be covering up for industry (asbestos, tobacco, and belgium sheep). In the cwd issue in texas the exact opposite is occuring. The govt. is actively working to DESTROY an industry.

I guess in your mind we all have cjd and cwd, are on the way to total destruction and God knows belgium and europe are all dead and we are just seeing holograms when we visit there right???

Please get help. And you don't have to report the results of that help here. up


Crotchety old bastidge
Re: CWD in Texas [Re: therancher] #5828551 07/12/15 04:49 PM
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Originally Posted By: therancher
Mr. Flounder, I'm concerned for your health.

You just posted that there were no positives in the mouse study... as proof that all prion related diseases are something for us all to be terrified of.

You also just used an example that (in your mind, which seems pretty far from reality right now) is related to the current cwd issue. I can assure you it is the opposite.

In your example the govt. was immagined to be covering up for industry (asbestos, tobacco, and belgium sheep). In the cwd issue in texas the exact opposite is occuring. The govt. is actively working to DESTROY an industry.

I guess in your mind we all have cjd and cwd, are on the way to total destruction and God knows belgium and europe are all dead and we are just seeing holograms when we visit there right???

Please get help. And you don't have to report the results of that help here. up




nope, you missed the relevance of the post all together bang

Re: CWD in Texas [Re: Frio County Hunts] #5828699 07/12/15 07:12 PM
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I'm a little confused myself on that one.

Re: CWD in Texas [Re: Frio County Hunts] #5828749 07/12/15 08:19 PM
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I think flounder was trying to say that; the government has totally screwed things up in the past and don't want to have anyone in a position to be able to prove it.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: jmh004] #5828774 07/12/15 08:41 PM
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Originally Posted By: jmh004
I'm a little confused myself on that one.


my point was missed entirely.

my point was _what the government is capable of doing_ with reference to the cwd tse prion aka mad cow type disease.

in reference to captive farmers, livestock, cwd tse prion aka mad cow type disease, I referenced another similar incident, long ago, with another TSE prion disease, politics behind it, and what indeed the government is _capable_ of doing, because they did it, when they were wrong from the beginning, and knew it, just to cover up an import blunder with a TSE prion disease.

I would be upset as well if I could not be on my own land to witness and film the slaughter of my own animals.

my point I suppose was to show you both sides of the fence with the politics from the tse prion disease, and like it or not, that is what CWD is.

you can't have the industry running things, and you can't let the government do it all with out checks and balances from the scientist and the people.


here's their story, maybe some of you will see here what i meant ;


http://jmyarlott.com/Articles/Mad%20Sheep/


and where we are today 2015 ;



Sunday, July 12, 2015

Insights into CWD and BSE species barriers using real-time conversion

http://transmissiblespongiformencephalop...se-species.html



kind regards, terry

Re: CWD in Texas [Re: nsmike] #5828777 07/12/15 08:43 PM
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Originally Posted By: nsmike
I think flounder was trying to say that; the government has totally screwed things up in the past and don't want to have anyone in a position to be able to prove it.



banana clap flehan

Re: CWD in Texas [Re: flounder] #5829787 07/13/15 03:11 PM
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My apologies Mr Flounder. I missed the key paragraph in your post that changed the meaning completely.

I'm not in the breeding industry btw. I'm in the hunting industry though, and I'm concerned that the state is following the fed example you cited, and I question the validity of the initial test. It could have been on purpose, it could have been an honest CoC issue.

But, the scorched earth policy will forever hide the truth.


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Re: CWD in Texas [Re: Frio County Hunts] #5830820 07/14/15 12:54 AM
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So apparently everyone is in Austin making their case. Breeders are being led by a lawyer who's has one of the best breeding ranches in Texas. The other side is being led by the Bass family. They have a huge hunting operation that's low fence. So HF vs LF, old money vs new money. However you want to look at it.

Re: CWD in Texas [Re: Frio County Hunts] #5831753 07/14/15 07:05 PM
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Tuesday, July 14, 2015

Texas Parks and Wildlife Commission Special Meeting Thursday on Chronic Wasting Disease CWD

http://chronic-wasting-disease.blogspot.com/2015/07/texas-parks-and-wildlife-commission.html

Re: CWD in Texas [Re: Frio County Hunts] #5831755 07/14/15 07:06 PM
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HOW DID THAT TEXAD DEER CZAR DR. DOUGH DO FOR WISCONSIN ???




Tuesday, July 14, 2015

TWO Escaped Captive Deer on the loose in Eau Claire County Wisconsin CWD postive farm Yellow ear tag

http://chronic-wasting-disease.blogspot.com/2015/07/two-escaped-captive-deer-on-loose-in.html





terry

Re: CWD in Texas [Re: Frio County Hunts] #5832272 07/15/15 12:39 AM
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He did quite a bit actually. Have you seen the deer up there?

Re: CWD in Texas [Re: flounder] #5832442 07/15/15 02:47 AM
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Originally Posted By: flounder
HOW DID THAT TEXAD DEER CZAR DR. DOUGH DO FOR WISCONSIN ???




Tuesday, July 14, 2015

TWO Escaped Captive Deer on the loose in Eau Claire County Wisconsin CWD postive farm Yellow ear tag

http://chronic-wasting-disease.blogspot.com/2015/07/two-escaped-captive-deer-on-loose-in.html





terry


He actually did a lot. Of course, folks who don't know squat and think the sky is falling might differ. But when Kroll went up their the dnr had gone Bat ch** crazy and had decided to try and kill all the deer in a few counties on the ignorant thought that that was a good idea to "control the spread of CWD". Even idiots can learn I guess, because they aren't doing that anymore.


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Re: CWD in Texas [Re: Frio County Hunts] #5832777 07/15/15 02:09 PM
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I know this is technically off topic but for those believers here, yet another mystery mankind, science, common sense, and vast amounts of interpretation and data can't get a handle on. Like most problems in our country we cannot agree on. Sometimes there are factors outside of our control or understanding no matter how intelligent or redneck or otherwise we are. Not saying that CWD or other issues may never be explained just that sometimes God works in mysterious ways. That despite our beliefs may not be what we think or feel is happening or right.

I am also impressed with knowledge, concern, and relatively friendly banter that has gone on in this thread. There was a little name calling and back and forth. Ultimately I think anyone who read this thread is better educated. Lf, hf, dr, redneck, old money, new money, no money, we gotta get along to make progress, and the more debate, conversation and more minds at work the better.

In my opinion CWD remains a challenge and a concern. What is God's will in all of this... who knows?

As for the constant bending of our great country's Constitution on a regular basis these days I hope we all stand up against any injustice. Those who have been put in bad situation financially and otherwise by all of this I hope for the best and easiest remediation possible.

Thanks for all the good reading and shared knowledge. Keep up the good work THF.

This sentence illustrates to me the God factor in our world:

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious.

All the [/i]
si-entistfic [i]
lingo ends in the sentence just ends with it is really a mystery.


-Those who say money can't buy happiness never bought a dog.

Re: CWD in Texas [Re: MoBettaHuntR] #5832914 07/15/15 04:12 PM
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Originally Posted By: MoBettaHuntR
I know this is technically off topic but for those believers here, yet another mystery mankind, science, common sense, and vast amounts of interpretation and data can't get a handle on. Like most problems in our country we cannot agree on. Sometimes there are factors outside of our control or understanding no matter how intelligent or redneck or otherwise we are. Not saying that CWD or other issues may never be explained just that sometimes God works in mysterious ways. That despite our beliefs may not be what we think or feel is happening or right.

I am also impressed with knowledge, concern, and relatively friendly banter that has gone on in this thread. There was a little name calling and back and forth. Ultimately I think anyone who read this thread is better educated. Lf, hf, dr, redneck, old money, new money, no money, we gotta get along to make progress, and the more debate, conversation and more minds at work the better.

In my opinion CWD remains a challenge and a concern. What is God's will in all of this... who knows?

As for the constant bending of our great country's Constitution on a regular basis these days I hope we all stand up against any injustice. Those who have been put in bad situation financially and otherwise by all of this I hope for the best and easiest remediation possible.

Thanks for all the good reading and shared knowledge. Keep up the good work THF.

This sentence illustrates to me the God factor in our world:

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious.

All the [/i]
si-entistfic [i]
lingo ends in the sentence just ends with it is really a mystery.


And that's exactly why it makes absolutely no logical sense to refuse the Pattersons offer to let them do research on this perfect sample. You don't solve mysteries by destroying your perfect sample population.


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Re: CWD in Texas [Re: therancher] #5833222 07/15/15 08:30 PM
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Originally Posted By: therancher
Originally Posted By: MoBettaHuntR
I know this is technically off topic but for those believers here, yet another mystery mankind, science, common sense, and vast amounts of interpretation and data can't get a handle on. Like most problems in our country we cannot agree on. Sometimes there are factors outside of our control or understanding no matter how intelligent or redneck or otherwise we are. Not saying that CWD or other issues may never be explained just that sometimes God works in mysterious ways. That despite our beliefs may not be what we think or feel is happening or right.

I am also impressed with knowledge, concern, and relatively friendly banter that has gone on in this thread. There was a little name calling and back and forth. Ultimately I think anyone who read this thread is better educated. Lf, hf, dr, redneck, old money, new money, no money, we gotta get along to make progress, and the more debate, conversation and more minds at work the better.

In my opinion CWD remains a challenge and a concern. What is God's will in all of this... who knows?

As for the constant bending of our great country's Constitution on a regular basis these days I hope we all stand up against any injustice. Those who have been put in bad situation financially and otherwise by all of this I hope for the best and easiest remediation possible.

Thanks for all the good reading and shared knowledge. Keep up the good work THF.

This sentence illustrates to me the God factor in our world:

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious.

All the [/i]
si-entistfic [i]
lingo ends in the sentence just ends with it is really a mystery.


And that's exactly why it makes absolutely no logical sense to refuse the Pattersons offer to let them do research on this perfect sample. You don't solve mysteries by destroying your perfect sample population.


Well said. cheers


Marc C. Helfrich
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Re: CWD in Texas [Re: Frio County Hunts] #5833409 07/15/15 10:55 PM
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Decision day is tomorrow in Austin. Should be interesting either way.

Re: CWD in Texas [Re: MoBettaHuntR] #5833444 07/15/15 11:21 PM
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Great post

Last edited by jmh004; 07/15/15 11:26 PM.
Re: CWD in Texas [Re: Frio County Hunts] #5833575 07/16/15 01:24 AM
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Very interesting read....
THE SKY IS NOT FALLING


Are idiots multiplying faster than normal people?[Linked Image]
Re: CWD in Texas [Re: Frio County Hunts] #5833705 07/16/15 03:11 AM
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Well this is from that guy, that according to some, has decimated the deer in Wisconsin. So what can we really get from this?

Re: CWD in Texas [Re: stxranchman] #5833742 07/16/15 03:51 AM
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Originally Posted By: stxranchman
Very interesting read....
THE SKY IS NOT FALLING


up Common Sense .. a breath of fresh air....

Last edited by SheepHunter; 07/16/15 03:53 AM.

Lucky 7 Exotic Ranch located in Eden, Tx. Well managed self sustaining herds roaming our 3,000 acre ranch. First Class Lodging, Ranch style meals and qualified guides. 30+ species.
Re: CWD in Texas [Re: Frio County Hunts] #5833752 07/16/15 03:59 AM
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I quit reading at "gorilla war"

Re: CWD in Texas [Re: LuckyHunter] #5833818 07/16/15 05:12 AM
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Originally Posted By: SheepHunter
Originally Posted By: stxranchman
Very interesting read....
THE SKY IS NOT FALLING


up Common Sense .. a breath of fresh air....


cheers texas


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Re: CWD in Texas [Re: spitfire] #5834123 07/16/15 02:24 PM
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Originally Posted By: spitfire
I quit reading at "gorilla war"


I don't let spelling errors keep me from learning.


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Re: CWD in Texas [Re: therancher] #5834126 07/16/15 02:26 PM
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This has some very interesting and pertinent info.

https://m.youtube.com/watch?v=1_ltc3dNsPk&feature=youtu.be


Crotchety old bastidge
Re: CWD in Texas [Re: therancher] #5834144 07/16/15 02:34 PM
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Originally Posted By: therancher
Originally Posted By: spitfire
I quit reading at "gorilla war"


I don't let spelling errors keep me from learning.



Re: CWD in Texas [Re: Frio County Hunts] #5834437 07/16/15 05:32 PM
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Rare report of deer disease in Texas causes stir

Houston Chronicle

Rare report of deer disease in Texas causes stir, especially since it’s the 8 case of CWD documented in Texas, and the first case of CWD in Captive deer.

here is how I would have titled this article, and why.

Shannon Tompkins Finally Breaks Silence on Texas First Captive CWD Case and Starts Off Spreading False Information About Risk Factors. ...

Thursday, July 16, 2015

http://chronic-wasting-disease.blogspot.com/2015/07/rare-report-of-deer-disease-in-texas.html

Re: CWD in Texas [Re: Frio County Hunts] #5834529 07/16/15 06:17 PM
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So are you saying CWD is not rare in Texas? I would think one positive test out of who knows how many deer is pretty rare. These links that you post are always hard to follow. They don't seem to have a sense of direction. Just FYI, not trying to start anything.

Last edited by jmh004; 07/16/15 06:19 PM.
Re: CWD in Texas [Re: Frio County Hunts] #5834534 07/16/15 06:19 PM
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This is a little far afield of CWD, but it shows that a monoclonal antibody, can stop a folded protein (prion) disease in its tracks. http://www.medpagetoday.com/Neurology/GeneralNeurology/52625 All the more reason to do as much research as possible.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: Frio County Hunts] #5834812 07/16/15 08:51 PM
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A few more positive tests show up, and the entire industry is serious jeopardy. Given CWD's propensity to spread readily in penned herds, I'd find it hard to believe more animals won't test positive.

Re: CWD in Texas [Re: Frio County Hunts] #5834826 07/16/15 08:57 PM
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Sound like they had a compromise in Austin. Tpwd will not slaughter the entire heard. They will kill and test the 29 deer closest to the positive deer. If they get another positive test, they move on to the next closest deer, and so on. A vast majority of breeders can move deer again. The only ranches that cant yet are the ones that bought and sold deer to and from that ranch in Medina.

Apparently the commissioners who made the decision were swayed by a vet who gave testimony about a live test that is 97% accurate. The vet said Texas can lead the nation in CWD research by using science, not slaughtering hundreds of animals.

So it sounds like the breeders won this one. Hopefully Texas does lead the nation in research of this disease. God knows it has the opportunity to do so with all the deer on farms in this state.

Re: CWD in Texas [Re: flounder] #5834868 07/16/15 09:19 PM
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Originally Posted By: flounder

Rare report of deer disease in Texas causes stir

Houston Chronicle

Rare report of deer disease in Texas causes stir, especially since it’s the 8 case of CWD documented in Texas, and the first case of CWD in Captive deer.

here is how I would have titled this article, and why.

Shannon Tompkins Finally Breaks Silence on Texas First Captive CWD Case and Starts Off Spreading False Information About Risk Factors. ...

Thursday, July 16, 2015

http://chronic-wasting-disease.blogspot.com/2015/07/rare-report-of-deer-disease-in-texas.html



This is like the pot calling the kettle black. You posting on your blog that humans are at serious risk is false as well because you have absolutely no facts to back that up.


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Re: CWD in Texas [Re: Frio County Hunts] #5834873 07/16/15 09:26 PM
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Blogs are extremely credible sources too. Vlogs are good too.

Re: CWD in Texas [Re: jmh004] #5834877 07/16/15 09:28 PM
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Originally Posted By: jmh004
So are you saying CWD is not rare in Texas? I would think one positive test out of who knows how many deer is pretty rare. These links that you post are always hard to follow. They don't seem to have a sense of direction. Just FYI, not trying to start anything.



there have been 8 confirmed cases of cwd in Texas to date that have been documented. documented is key word...kind regards, terry

Re: CWD in Texas [Re: Pitchfork Predator] #5834883 07/16/15 09:30 PM
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Originally Posted By: Pitchfork Predator
Originally Posted By: flounder

Rare report of deer disease in Texas causes stir

Houston Chronicle

Rare report of deer disease in Texas causes stir, especially since it’s the 8 case of CWD documented in Texas, and the first case of CWD in Captive deer.

here is how I would have titled this article, and why.

Shannon Tompkins Finally Breaks Silence on Texas First Captive CWD Case and Starts Off Spreading False Information About Risk Factors. ...

Thursday, July 16, 2015

http://chronic-wasting-disease.blogspot.com/2015/07/rare-report-of-deer-disease-in-texas.html



This is like the pot calling the kettle black. You posting on your blog that humans are at serious risk is false as well because you have absolutely no facts to back that up.



*** LATE-BREAKING ABSTRACTS PRION 2015 CONFERENCE ***

O18

Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection.

==================

***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection.***

==================

P.105: RT-QuIC models trans-species prion transmission

Kristen Davenport, Davin Henderson, Candace Mathiason, and Edward Hoover Prion Research Center; Colorado State University; Fort Collins, CO USA

The propensity for trans-species prion transmission is related to the structural characteristics of the enciphering and heterologous PrP, but the exact mechanism remains mostly mysterious. Studies of the effects of primary or tertiary prion protein structures on trans-species prion transmission have relied primarily upon animal bioassays, making the influence of prion protein structure vs. host co-factors (e.g. cellular constituents, trafficking, and innate immune interactions) difficult to dissect. As an alternative strategy, we used real-time quakinginduced conversion (RT-QuIC) to investigate trans-species prion conversion.

To assess trans-species conversion in the RT-QuIC system, we compared chronic wasting disease (CWD) and bovine spongiform encephalopathy (BSE) prions, as well as feline CWD (fCWD) and feline spongiform encephalopathy (FSE). Each prion was seeded into each host recombinant PrP (full-length rPrP of white-tailed deer, bovine or feline). We demonstrated that fCWD is a more efficient seed for feline rPrP than for white-tailed deer rPrP, which suggests adaptation to the new host.

Conversely, FSE maintained sufficient BSE characteristics to more efficiently convert bovine rPrP than feline rPrP. Additionally, human rPrP was competent for conversion by CWD and fCWD. ***This insinuates that, at the level of protein:protein interactions, the barrier preventing transmission of CWD to humans is less robust than previously estimated.

================

***This insinuates that, at the level of protein:protein interactions, the barrier preventing transmission of CWD to humans is less robust than previously estimated.***

================

https://prion2015.files.wordpress.com/2015/05/programguide1.pdf

Re: CWD in Texas [Re: Frio County Hunts] #5834885 07/16/15 09:32 PM
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Ok, so 8 confirmed cases against the millions of deer in Texas. Sounds unbelievably rare to me.

Re: CWD in Texas [Re: Pitchfork Predator] #5834888 07/16/15 09:32 PM
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Originally Posted By: Pitchfork Predator
Originally Posted By: flounder

Rare report of deer disease in Texas causes stir

Houston Chronicle

Rare report of deer disease in Texas causes stir, especially since it’s the 8 case of CWD documented in Texas, and the first case of CWD in Captive deer.

here is how I would have titled this article, and why.

Shannon Tompkins Finally Breaks Silence on Texas First Captive CWD Case and Starts Off Spreading False Information About Risk Factors. ...

Thursday, July 16, 2015

http://chronic-wasting-disease.blogspot.com/2015/07/rare-report-of-deer-disease-in-texas.html



This is like the pot calling the kettle black. You posting on your blog that humans are at serious risk is false as well because you have absolutely no facts to back that up.


part 2 ;


HUMANS

In conclusion, an analysis of dietary histories revealed statistical associations between various meats/animal products and INCREASED RISK OF CJD. When some account was taken of possible confounding, the association between VEAL EATING AND RISK OF CJD EMERGED AS THE STRONGEST OF THESE ASSOCIATIONS STATISTICALLY. ...

snip...

In the study in the USA, a range of foodstuffs were associated with an increased risk of CJD, including liver consumption which was associated with an apparent SIX-FOLD INCREASE IN THE RISK OF CJD. By comparing the data from 3 studies in relation to this particular dietary factor, the risk of liver consumption became non-significant with an odds ratio of 1.2 (PERSONAL COMMUNICATION, PROFESSOR A. HOFMAN. ERASMUS UNIVERSITY, ROTTERDAM). (???...TSS)

snip...see full report ;

http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/yb/1994/08/00004001.pdf

Thursday, October 10, 2013

*************CJD REPORT 1994 increased risk for consumption of veal and venison and lamb**************

http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-report-1994-increased-risk-for.html

CJD9/10022

October 1994

Mr R.N. Elmhirst Chairman British Deer Farmers Association Holly Lodge Spencers Lane BerksWell Coventry CV7 7BZ

Dear Mr Elmhirst,

CREUTZFELDT-JAKOB DISEASE (CJD) SURVEILLANCE UNIT REPORT

Thank you for your recent letter concerning the publication of the third annual report from the CJD Surveillance Unit. I am sorry that you are dissatisfied with the way in which this report was published.

The Surveillance Unit is a completely independant outside body and the Department of Health is committed to publishing their reports as soon as they become available. In the circumstances it is not the practice to circulate the report for comment since the findings of the report would not be amended. In future we can ensure that the British Deer Farmers Association receives a copy of the report in advance of publication.

The Chief Medical Officer has undertaken to keep the public fully informed of the results of any research in respect of CJD. This report was entirely the work of the unit and was produced completely independantly of the the Department.

The statistical results reqarding the consumption of venison was put into perspective in the body of the report and was not mentioned at all in the press release. Media attention regarding this report was low key but gave a realistic presentation of the statistical findings of the Unit. This approach to publication was successful in that consumption of venison was highlighted only once by the media ie. in the News at one television proqramme.

I believe that a further statement about the report, or indeed statistical links between CJD and consumption of venison, would increase, and quite possibly give damaging credence, to the whole issue. From the low key media reports of which I am aware it seems unlikely that venison consumption will suffer adversely, if at all.

http://web.archive.org/web/20030511010117/http://www.bseinquiry.gov.uk/files/yb/1994/10/00003001.pdf

Thursday, October 10, 2013

*** CJD REPORT 1994 increased risk for consumption of veal and venison and lamb

http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-report-1994-increased-risk-for.html

PLUS, THE CDC DID NOT PUT THIS WARNING OUT FOR THE WELL BEING OF THE DEER AND ELK ;

Thursday, May 26, 2011

Travel History, Hunting, and Venison Consumption Related to Prion Disease Exposure, 2006-2007 FoodNet Population Survey Journal of the American Dietetic Association Volume 111, Issue 6 , Pages 858-863, June 2011. http://transmissiblespongiformencephalop...nd-venison.html

NOR IS THE FDA recalling this CWD positive elk meat for the well being of the dead elk ;

Wednesday, March 18, 2009

Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II

http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html

now, let’s see what the authors said about this casual link, personal communications years ago. see where it is stated NO STRONG evidence. so, does this mean there IS casual evidence ???? “Our conclusion stating that we found no strong evidence of CWD transmission to humans”

From: TSS (216-119-163-189.ipset45.wt.net) Subject: CWD aka MAD DEER/ELK TO HUMANS ???

Date: September 30, 2002 at 7:06 am PST From: "Belay, Ermias"

To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"

Sent: Monday, September 30, 2002 9:22 AM

Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Dear Sir/Madam,

In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD. That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.

Ermias Belay, M.D. Centers for Disease Control and Prevention

-----Original Message-----

From:

Sent: Sunday, September 29, 2002 10:15 AM

To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV

Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS

Thursday, April 03, 2008

A prion disease of cervids: Chronic wasting disease

2008 1: Vet Res. 2008 Apr 3;39(4):41 A prion disease of cervids: Chronic wasting disease Sigurdson CJ.

snip...

*** twenty-seven CJD patients who regularly consumed venison were reported to the Surveillance Center***,

snip... full text ;

http://chronic-wasting-disease.blogspot.com/2008/04/prion-disease-of-cervids-chronic.html

*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).

https://www.landesbioscience.com/journals/prion/article/28124/?nocache=112223249

*** The potential impact of prion diseases on human health was greatly magnified by the recognition that interspecies transfer of BSE to humans by beef ingestion resulted in vCJD. While changes in animal feed constituents and slaughter practices appear to have curtailed vCJD, there is concern that CWD of free-ranging deer and elk in the U.S. might also cross the species barrier. Thus, consuming venison could be a source of human prion disease. Whether BSE and CWD represent interspecies scrapie transfer or are newly arisen prion diseases is unknown. Therefore, the possibility of transmission of prion disease through other food animals cannot be ruled out. There is evidence that vCJD can be transmitted through blood transfusion. There is likely a pool of unknown size of asymptomatic individuals infected with vCJD, and there may be asymptomatic individuals infected with the CWD equivalent. These circumstances represent a potential threat to blood, blood products, and plasma supplies.

http://cdmrp.army.mil/prevfunded/nprp/NPRP_Summit_Final_Report.pdf


kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5834890 07/16/15 09:33 PM
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You can stop posting the exact same thing over and over again too. We got it!

Re: CWD in Texas [Re: jmh004] #5834892 07/16/15 09:33 PM
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Originally Posted By: jmh004
Ok, so 8 confirmed cases against the millions of deer in Texas. Sounds unbelievably rare to me.


Thank you sir.



Re: CWD in Texas [Re: jmh004] #5834898 07/16/15 09:36 PM
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Originally Posted By: jmh004
Ok, so 8 confirmed cases against the millions of deer in Texas. Sounds unbelievably rare to me.



remember what I said, the key word there was _documented_ cases of cwd in Texas to date, is at 8 cases. CWD has been waltzing across the border into Texas around the WSMR for over a decade, and the testing in captives and the wild is not sufficient, in my opinion, and please don't give me the bs that these farmers are testing all their captive deer. they do NOT test the escapees. ...



Tuesday, July 14, 2015

TWO Escaped Captive Deer on the loose in Eau Claire County Wisconsin CWD postive farm Yellow ear tag

http://chronic-wasting-disease.blogspot.com/2015/07/two-escaped-captive-deer-on-loose-in.html


kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5834900 07/16/15 09:38 PM
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Indeed they have potential....so does the earth to destroy itself from within..

I'm sorry about what happened to your mother and my condolences. But you are running way off the track comparing beef that were fed beef that produced an anomaly that killed a very few people when looking at population numbers.

Please stop it. And let's get the train back on the track.


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Re: CWD in Texas [Re: jmh004] #5834909 07/16/15 09:41 PM
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Originally Posted By: jmh004
Sound like they had a compromise in Austin. Tpwd will not slaughter the entire heard. They will kill and test the 29 deer closest to the positive deer. If they get another positive test, they move on to the next closest deer, and so on. A vast majority of breeders can move deer again. The only ranches that cant yet are the ones that bought and sold deer to and from that ranch in Medina.

Apparently the commissioners who made the decision were swayed by a vet who gave testimony about a live test that is 97% accurate. The vet said Texas can lead the nation in CWD research by using science, not slaughtering hundreds of animals.

So it sounds like the breeders won this one. Hopefully Texas does lead the nation in research of this disease. God knows it has the opportunity to do so with all the deer on farms in this state.



if that is true, Texas just opened up the door for cwd tse prion disease to be trucked/spread to every state that has anything to do with Texas. but that's not unusual, they did this with BSE tse prion as well. nothing knew, just political and corporate junk science at it's best, and Texas is full of that. it's what happens when you let corporations run the government. good luck with that. ...


kind regards, terry


Last edited by flounder; 07/16/15 09:42 PM.
Re: CWD in Texas [Re: Pitchfork Predator] #5834919 07/16/15 09:46 PM
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Originally Posted By: Pitchfork Predator
Indeed they have potential....so does the earth to destroy itself from within..

I'm sorry about what happened to your mother and my condolences. But you are running way off the track comparing beef that were fed beef that produced an anomaly that killed a very few people when looking at population numbers.

Please stop it. And let's get the train back on the track.



I believe you are wrong in your assumptions sir. please see ;



O.05: Transmission of prions to primates after extended silent incubation periods: Implications for BSE and scrapie risk assessment in human populations

Emmanuel Comoy, Jacqueline Mikol, Valerie Durand, Sophie Luccantoni, Evelyne Correia, Nathalie Lescoutra, Capucine Dehen, and Jean-Philippe Deslys Atomic Energy Commission; Fontenay-aux-Roses, France

Prion diseases (PD) are the unique neurodegenerative proteinopathies reputed to be transmissible under field conditions since decades. The transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that an animal PD might be zoonotic under appropriate conditions. Contrarily, in the absence of obvious (epidemiological or experimental) elements supporting a transmission or genetic predispositions, PD, like the other proteinopathies, are reputed to occur spontaneously (atpical animal prion strains, sporadic CJD summing 80% of human prion cases). Non-human primate models provided the first evidences supporting the transmissibiity of human prion strains and the zoonotic potential of BSE. Among them, cynomolgus macaques brought major information for BSE risk assessment for human health (Chen, 2014), according to their phylogenetic proximity to humans and extended lifetime. We used this model to assess the zoonotic potential of other animal PD from bovine, ovine and cervid origins even after very long silent incubation periods. We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period, with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014), is the third potentially zoonotic PD (with BSE and L-type BSE), ***thus questioning the origin of human sporadic cases. We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.

===============

***thus questioning the origin of human sporadic cases...TSS

===============


ALSO, PLEASE SEE ;

31 Jan 2015 at 20:14 GMT

*** Ruminant feed ban for cervids in the United States? ***

31 Jan 2015 at 20:14 GMT

http://www.plosone.org/annotation/listThread.action?root=85351

http://chronic-wasting-disease.blogspot.com/

Saturday, May 30, 2015

PRION 2015 ORAL AND POSTER CONGRESSIONAL ABSTRACTS

https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf

http://transmissiblespongiformencephalopathy.blogspot.com/2015/05/prion-2015-oral-and-poster.html


kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5834924 07/16/15 09:48 PM
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Wow, bitter much? Sounds like Texas just looked and what other states have done in the past and saw that none of that actually worked. Kudos to the state for not listening to people who are paranoid and post links from blogs like they're Bill Nye the Science Guy. If people don't like how the state is run, there's always the option to move to California or Russia.

Re: CWD in Texas [Re: jmh004] #5834930 07/16/15 09:50 PM
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Originally Posted By: jmh004
Sound like they had a compromise in Austin. Tpwd will not slaughter the entire heard. They will kill and test the 29 deer closest to the positive deer. If they get another positive test, they move on to the next closest deer, and so on. A vast majority of breeders can move deer again. The only ranches that cant yet are the ones that bought and sold deer to and from that ranch in Medina.

Apparently the commissioners who made the decision were swayed by a vet who gave testimony about a live test that is 97% accurate. The vet said Texas can lead the nation in CWD research by using science, not slaughtering hundreds of animals.

So it sounds like the breeders won this one. Hopefully Texas does lead the nation in research of this disease. God knows it has the opportunity to do so with all the deer on farms in this state.


cheers texas


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Re: CWD in Texas [Re: Frio County Hunts] #5834939 07/16/15 09:56 PM
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Terry,

I suggest you evaluate what your doing. It's not effective or convincing.

It's become irritating.

kind regards,

Marc


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Re: CWD in Texas [Re: jmh004] #5834940 07/16/15 09:57 PM
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Originally Posted By: jmh004
Wow, bitter much? Sounds like Texas just looked and what other states have done in the past and saw that none of that actually worked. Kudos to the state for not listening to people who are paranoid and post links from blogs like they're Bill Nye the Science Guy. If people don't like how the state is run, there's always the option to move to California or Russia.


yep, that's working out real well for Wisconsin. ...


Wednesday, March 04, 2015

Disease sampling results provide current snapshot of CWD in Wisconsin finding 324 positive detections statewide in 2014

http://chronic-wasting-disease.blogspot.com/2015/03/disease-sampling-results-provide.html


Wisconsin : 436 Deer Have Escaped From Farms to Wild

Date: March 18, 2003 Source: Milwaukee Journal Sentinel

Contacts: LEE BERGQUIST lbergquist@journalsentinel.com

State finds violations, lax record keeping at many sites, report says A state inspection of private deer farms, prompted by the discovery of chronic wasting disease, found that 436 white-tailed deer escaped into the wild, officials said Tuesday

The Department of Natural Resources found that captive deer have escaped from one-third of the state's 550 deer farms over the lifetime of the operations. The agency also uncovered hundreds of violations and has sought a total of 60 citations or charges against deer farm operators.

Hundreds of deer escape

The DNR found a total of 671 deer that escaped farms - 436 of which were never found - because of storm-damaged fences, gates being left open or the animals jumping over or through fences.

In one example in Kewaunee County, a deer farmer's fence was knocked down in a summer storm. Ten deer escaped, and the farmer told the DNR he had no intention of trying to reclaim them. The DNR found five of the deer, killed them and cited the farmer for violation of a regulation related to fencing.

Another deer farmer near Mishicot, in Manitowoc County, released all nine of his whitetails last summer after he believed the discovery of chronic wasting disease was going to drive down the market for captive deer.

The DNR found 24 instances of unlicensed deer farms and issued 19 citations.

Game Farms Inspected

A summary of the findings of the Department of Natural Resources' inspection of 550 private white-tailed deer farms in the state: The deer farms contained at least 16,070 deer, but the DNR believes there are more deer in captivity than that because large deer farms are unable to accurately count their deer. 671 deer had escaped from game farms, including 436 that were never found.

24 farmers were unlicensed. One had been operating illegally since 1999 after he was denied a license because his deer fence did not meet minimum specifications.

Records maintained by operators ranged from "meticulous documentation to relying on memory." At least 227 farms conducted various portions of their deer farm business with cash. Over the last three years, 1,222 deer died on farms for various reasons. Disease testing was not performed nor required on the majority of deer. Farmers reported doing business with people in 22 other states and one Canadian province. ..

http://www.cwd-info.org/index.php/fuseaction/news.detail/ID/4eb67da18ca2c69fce5b5f2eaad058e8

How’s that Texas Deer Czar expert Dr. Dough that Governor Scott Walker hired, how is that working for you now in Wisconsin $$$

Escaped Captive Deer on the loose in Eau Claire County

By Central Office July 14, 2015 Contact(s): Bill Hogseth, DNR Wildlife Biologist, Eau Claire & Chippewa counties, 715-839-3771 Harvey Halvorsen, DNR Area Wildlife Supervisor, 715-684-2914 Ext. 113 Tami Ryan, DNR Wildlife Health Section Chief, 608-266-3143

EAU CLAIRE, Wis. -- The state Department of Natural Resources is requesting the help of residents of Fairchild and Augusta and the surrounding areas to be on the lookout for two escaped ear-tagged captive white-tailed deer from a local captive deer facility.

On June 24 the Department of Agriculture, Trade, & Consumer Protection [PDF] (exit DNR ) announced a captive white-tailed deer from a breeding farm in Eau Claire County has tested positive for chronic wasting disease.

In early May, the farm owner reported that multiple captive bucks escaped the facility when a tree fell on the fence causing a breach. Most of the escaped bucks were recovered with two still remaining out on the landscape.

"We need landowners and the public to be on the lookout for any deer that appear to have an ear tag. These captive escapes are a potential health risk to the local wild deer herd and should be removed from the landscape," said DNR wildlife biologist Bill Hogseth.

Ear tag Yellow plastic ear-tags are likely to be on these two bucks. WDNR Photo

Landowners are asked to check trail camera images for any ear-tagged deer. The DNR would like to be notified if you record any images of ear-tagged deer or if you observe any. While yellow plastic ear-tags like the one pictured are most common and likely to be on these two bucks, please report any deer tagged with any size, shape or color of ear-tag.

If it is after hours, or a biologist isn't available please contact the department's hotline at 1-800-847-9367. The information will be forwarded to the local conservation warden.

Anyone interested in learning more about CWD in Wisconsin can search the DNR website, dnr.wi.gov, for keyword "CWD").

Last Revised: Tuesday, July 14, 2015

http://dnr.wi.gov/news/releases/article/?id=3650

http://datcp.wi.gov/news/



CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) FarmUpdate DECEMBER 2011The CWD infection rate was nearly 80%, the highest ever in a North American captive herd. RECOMMENDATION: That the Board approve the purchase of 80acres of land for $465,000 for the Statewide Wildlife Habitat Program inPortage County and approve the restrictions on public use of the site.SUMMARY:

http://dnr.wi.gov/about/nrb/2011/december/12-11-2b2.pdf




kind regards, terry



Last edited by flounder; 07/16/15 09:58 PM. Reason: added link to dnr buckhorn flats
Re: CWD in Texas [Re: Frio County Hunts] #5834948 07/16/15 10:00 PM
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Dude, please stop posting the same posts repeatedly. We got it, really.

Re: CWD in Texas [Re: Frio County Hunts] #5835354 07/17/15 01:54 AM
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Here is a long read that I received in an email from a testimony that was given on Monday in Austin. He is just stating facts as he sees them.
Quote:
Testimony before Texas House of Representatives Committee on Culture Recreation & Tourism
Monday July 13, 1 pm
Mister Chairman Guillen
Madam Vice Chair Dukes
Esteemed members of the Committee:
Representatives Frullo,Larson,Marquez,Murray, and Smith. QALadies and gentlemen:
Thank you for inviting me to appear before this august body today.
My name is Greg Stewart.
I live in the world of translational medicine and infectious disease. I come from a long line of
physicians and my children continue that tradition. Both currently are in medical school. One is a
senior. The other is in a clinician scientist training (MD/PhD combined) program.
First you have asked me to qualify myself for this role.
I submitted for your review a short synopsis of a much longer curriculum vitae. This you can
peruse at your leisure. My legal residence is in rural Oconee County, Georgia. I work in Texas
between two and three months per year. So howdy!
I hold a Masters of Science in livestock and poultry. I hold a PhD in medical microbiology which
was heavily loaded with pathology, diagnostics, laboratory techniques, and epidemiology.
I hold a Doctor of Veterinary Medicine degree and am licensed to practice in this state and
others. I'm a former faculty member of University of Georgia's College of Veterinary Medicine.
My home department there is called the Department of Population Medicine.I have worked as a
clinician in a very specialized training program for graduate veterinarians and was an integral
part of its diagnostic laboratory system.
I have been for 38 years a servant to production animal medicine. I have been blessed to be able
to design, implement, and supervise "specific pathogen free" programs on multiple species on all
seven continents. This involved surveillance, diagnostics, pathogenesis, biosecurity, genetic
susceptibility, understanding of multiplicity of infection, and modes of transmission.
My family are shepherds. We are primary breeders of fine single purpose meat sheep.
In my veterinary practice we deal daily with decisions, questions, comments, and government
compliance issues relating to a Transmissible Spongiform Encephalopathy(TSE) agent called
scrapie(sheep and goats) and another TSE called Chronic Wasting Disease of Cervids (CWD).
These are also called prion diseases. We routinely test all of our own breeding stock for genetic
resistance to scrapie and the older ewes are tested post mortem for scrapie. There is an USDA
surveillance program governing this agent just as there is one governing Chronic Wasting
Disease. CWD is the subject of this hearing.
I help teach a class with the College of Veterinary Medicine UGA each year in which we train
graduating veterinarians about TSEs and how to monitor flocks and herds using rectal biopsy,
genetic susceptibility testing, and immunohistochemical (IHC) techniques used on collected post
mortem tissues.
For the past seventeen years I have served the Texas small ruminant industry (sheep, goats, and
deer) in various capacities relating to wellness, nutrition, herd health, and reproduction. The
cervid industry is served by our practice in ten or more states each year. We have contributed
considerable resources to public education about CWD. Our website,www.southernvet.co,
contains a reasonably current lecture on the subject. We have cooperated with several television
producers to educate the general public about CWD. We stay current with most newly published
material on the topic. I am knowledgeable of the USDA-APHIS CWD program. I have,for four
years, served as a technical resource for members of Georgia's House of Representatives and
Senate in their evaluation of the risks and benefits of deer farming as they contemplate it.
Secondly you have asked about recommendations about how to eradicate or control CWD.
Let us confine our remarks to management and control because I know of no location or agency
in North America that would lay claim to eradication. In fact, those who have tried are now
changing their strategy towards management and control.
In any "management and control" program, stakeholders must lay down some operational
paradigms and get agreement upon them before that program can be successful.
1. There must be agreement amongst ALL that the work and the plan must be objective and
science based.
2. ALL must agree that "time is of the essence" in dealing with quarantines, release of
quarantines, notifications, and laboratory testing.
3. ALL should agree that if better knowledge and understanding of the disease agent can be
gleaned in the exercise , that we are obligated to seek that knowledge so long as it doesn't
co-opt the program, endanger other at risk animals, or the public health.
4. There must be agreement that bureaucratic turf and competing agency agenda have NO
role in disease control strategies that have as their highest priority objectivity and good
science.
5. The public is a stakeholder and public education about the risks and benefits of the
control program is crucial. There should be ONE assigned, knowledgeable, qualified,
unified voice that is the source of that education and other releases to the public from the
state government.
6. ALL should agree that “the fix" of the problem should NOT be more deadly or
devastating than the disease.
7. ALL must agree to respect the dignity of the animals involved and respect the dignity of
the ranchers involved who have cared for these animals throughout their lives. We must
respect the dignity of the human animal bond. If we do not, we will lessen ourselves in
eyes of the public and our creator. There is precedent for these concerns that arises from
the mass slaughter of animals in the Foot and Mouth Disease outbreak in the UK. If
animals are sacrificed and they will be, we must seek ALL possible knowledge that
furthers our understanding of the disease otherwise that animal's life has been assigned
lesser value than it should have been. All sacrificed animals should be genotyped at
codons 95 & 96 and that information catalogued with its unique DNA information about
parentage.Each should undergo state of the art antemortem testing prior to be being
sacrificed. Retropharyngeal lymph nodes,palatine tonsil, and obex should be harvested
post mortem. As these ranches are visited, biosecurity should play a leading role in
countering transmission from one ranch to another and out to the general environs.
People and equipment are highly efficient fomites and vectors.
The refereed published evidence about CWD contains a plethora of information about the
disease called CWD. Simply put prion diseases are actually proteins that become misfolded.
They create problems when normal conformation changes because structure in protein is part of
function.Vast expenditures have been let in a quest for understanding. My mission here is not to
regurgitate these reviews but to try to put a few things in perspective for your deliberations.
We must seek actual risk and not theoretical risk.
Routes of infection. There are major differences in natural routes of exposure to CWD, such as
ingestion, and unnatural or artificial routes of infection, such as injection of infected material into
the brain of a target species. Our priorities should be on natural routes of exposure.
Exposure does not mean infection.
The incubation period of CWD is quite long compared to viral or bacterial or fungal etiologies.
A positive diagnosis made by IHC staining of tissues occurs long before any clinical signs of the
disease are evident.
We don't completely understand the agent or all the modes of transmission. We are learning
more each year. The agent can be spread by live animal to animal contact, through contaminated
soil, urine, feces, saliva, and recently it appears that plants can uptake the prion from either
contaminated soil or by contaminated sprays or washings of leaves and that the dose found in the
plant matter thereafter is sufficient for transmission by the natural oral route.
Dead carcasses of positive animals or body parts thereof can be sources of infection.
CWD is not highly infectious. Sometimes natural exposure to the agent for 90 days straight is
barely enough to transmit disease. Mathiason et al. 2009 PLoS ONE
4(6)e5916,doi:10.1371/journal.pone.005916
Most TSE computer models have failed the test of accuracy over time. The early predictions
from the BSE models in Europe predicted 54,000 human deaths from variant CJD. The total
stands at less than 150 several decades later.( Each life lost was missed by someone and was a
tragedy).
The early computer models for CWD predicted that it would decimate the nation’s entire herd.
Computer models were very efficient in genning up fear, public outcry, and research funding.
Cases of CWD are terminal when followed to the end of the course of the disease. Most CWD
positive deer die before ever exhibiting clinical symptoms.
Certain genotypes coding for long incubation periods or resistance to infection may be being
selected for in the wild. This may in time strengthen the nation’s deer herd.
CWD does not affect other livestock by natural transmission methods. No evidence exists to
refute this statement.
There is NO evidence that eating venison from positive deer is a public health hazard. A case
history of a large number of individuals who were accidentally fed venison from a positive deer
is recorded from the Verona Fire Department in Oneida, NY. Those individuals have all been
followed for ten years and the study terminated this year with no incidence of zoonotic disease.
Man has likely been eating scrapie positive meat from sheep or goats for over 200 years.
Australia is free of scrapie and the incidence of human TSEs is no different there than in
countries that have scrapie.
There is NO evidence that CWD or any other TSE can be transmitted by semen or embryos.
There are case studies and very efficient models of CWD management and control strategies that
have been used by other states, e.g. PA,NY.
The pathology of CWD and BSE in the brains of infected subjects is distinct from each other.
The incidence of CWD in free range cervids is higher than the incidence in captive cervids by a
fourfold factor based on USDA statistics.
CWD respects no borders. CWD positive mule deer walked across the TX-NM border several
years ago.
There is no difference in harvest rates between infected and non infected individuals. Grear et al.
2006 quoted by Kroll, James C. White paper CWD : the issues at hand. July 2013
CWD has a higher incidence in males than in females.
TSEs as disease agents are RARE.
Rabies in deer is very rare. CWD is more rare than cervid rabies.
Examples, by contrast, of highly infectious diseases of deer that are very virulent and cause
significant mortality would include epizootic hemorrhagic disease( EHD), a viral agent, and in
south Texas, Anthrax, a bacterial infection caused by Bacillus anthracis. Anthrax is also a potent
public health risk.
The rate of infection or at least the progression of the disease is slowed in animals that have
unique amino acid sequences at various loci in their genetic code. Some species of cervids are
more susceptible than others. The mule deer appears up to ten times more susceptible than the
whitetail.
In other species TSEs are documented that are spontaneous or sporadic in nature, i.e. there is no
casual epidemiology. The normal proteins that are present in healthy bodies apparently change
and begin to misfold. In fact with the most well studied human TSE, Creutzfeldt-Jakob Disease
(CJD), approximately 80 % of the cases are sporadic/spontaneous. The incidence of this disease
is rare also. Approximately one case per million persons is well documented. Other TSEs are
familial in man. In CJD, genotype plays a critical role in susceptibility.
Task three:
How do we balance the interests of the deer breeding industry with preventing the spread of the
disease?
The deer breeding industry is ranked among the top ten agricultural commodities in the state of
Texas. Recent surveys place its value at over at over $1 billion per annum and it is an integral
part of the multibillion dollar hunting industry.
There are currently several models that have been used effectively for control.There is a national
model. Based on known incubation periods, a five year trace back and trace forward period
seems to be reasonable.
The comments herein are based on science, known elements of the disease, coupled with
experience.
As I understand the numbers:
A 2.0+ year old buck was the index case. He was raised on the index ranch. There were 126 deer
that entered the index facility. 26 remain there.
Priority one:
Freeze movement of any connected ranch inbound or outbound for now.Allow unrelated ranches
in TX to sign affidavits attesting to unrelatedness and apply for “movement qualified”.
Geography and proximity have less value than relatedness. Ranchers who are unrelated and who
only release stockers to their own high fence property that is contiguous to their pens are of
lowest priority.
Test antemortem and post mortem all of the inbound group or account for them. This can be
easily done by transfer permit computer search. Likely some of the 100 that came in and left
have been tested prior to June 30,2015.
Test all remaining deer at index facility.
Analyze results. If all results are “not detected/not positive” we may be documenting a
spontaneous case of CWD or one transmitted by carrion eaters, predators, or via contaminated
plant matter shipped in and used as forage.
If the index ranch suffers any positives then downstream ranches move into heightened priority
status and are dealt with in the same manner as the index ranch.
If results are “not detected/not positive” on the index ranch, the downstream ranches are now the
remaining concern .
In the meantime, any downstream ranch that voluntarily sacrifices those related animals in toto
via official means and tissue collections and whose test results are returned as “not detected/not
positive” should be able to apply for “ movement qualified”. The balance of downstream
individuals should be livability verified or confirmed dead and tested by rectal biopsy and codon
testing at position 95/96 if deemed an additional risk by authorities.
If any downstream animal turns up positive then that facility now becomes activated for
additional investigation using the same logic as above.
Respectfully submitted.


Are idiots multiplying faster than normal people?[Linked Image]
Re: CWD in Texas [Re: Frio County Hunts] #5835356 07/17/15 01:55 AM
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CWD.....Decision up same post over & over

Last edited by SheepHunter; 07/17/15 02:37 AM.

Lucky 7 Exotic Ranch located in Eden, Tx. Well managed self sustaining herds roaming our 3,000 acre ranch. First Class Lodging, Ranch style meals and qualified guides. 30+ species.
Re: CWD in Texas [Re: Frio County Hunts] #5835363 07/17/15 01:58 AM
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That's good stuff right there. No evidence of humans being infected from consuming meat from an infected deer. I think the state did a stand up job at looking at all the facts.

Re: CWD in Texas [Re: Frio County Hunts] #5835686 07/17/15 12:31 PM
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Thanks stxranchman. Nice to see a post from someone with facts and common sense solutions. This makes me proud to be a Texan to see we don't follow, we lead. cheers texas


Marc C. Helfrich
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Re: CWD in Texas [Re: Frio County Hunts] #5835690 07/17/15 12:34 PM
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Amen!

Re: CWD in Texas [Re: Frio County Hunts] #5835839 07/17/15 02:17 PM
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Friday, July 17, 2015

TPW Commission Holds Special Meeting on Chronic Wasting Disease

http://chronic-wasting-disease.blogspot.com/2015/07/tpw-commission-holds-special-meeting-on.html


kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5835857 07/17/15 02:29 PM
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You really shouldn't attach your blather to official links. It's bad form IMO.

Really? "Texas fell to mad cow disease"??

I guess I slept thru that.


Crotchety old bastidge
Re: CWD in Texas [Re: therancher] #5835872 07/17/15 02:37 PM
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kind of a big deal
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Originally Posted By: therancher
You really shouldn't attach your blather to official links. It's bad form IMO.

Really? "Texas fell to mad cow disease"??

I guess I slept thru that.


A UK immigrant died of vCJD earlier this year. He relocated to TX but still traveled a lot to the UK and Middle East


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: BOBO the Clown] #5836145 07/17/15 05:24 PM
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Originally Posted By: BOBO the Clown
Originally Posted By: therancher
You really shouldn't attach your blather to official links. It's bad form IMO.

Really? "Texas fell to mad cow disease"??

I guess I slept thru that.


A UK immigrant died of vCJD earlier this year. He relocated to TX but still traveled a lot to the UK and Middle East


Yeah, and I'm fairly certain you and I agree that "Texas fell to mad cow disease" is probably a tad extreme in that description.

And imbedding his blather in technical linked information is IMO poor form.

Last edited by therancher; 07/17/15 05:30 PM.

Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5836156 07/17/15 05:32 PM
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And then some...

Not saying I would cry over another mad cow scare. Made a lot of money last time it temporarily depressed the market


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: LuckyHunter] #5836181 07/17/15 05:46 PM
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Originally Posted By: SheepHunter
CWD.....Decision up same post over & over


clap funny clip


Marc C. Helfrich
Retirement Planner

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Re: CWD in Texas [Re: BOBO the Clown] #5837667 07/18/15 10:40 PM
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Originally Posted By: BOBO the Clown
Originally Posted By: therancher
You really shouldn't attach your blather to official links. It's bad form IMO.

Really? "Texas fell to mad cow disease"??

I guess I slept thru that.


A UK immigrant died of vCJD earlier this year. He relocated to TX but still traveled a lot to the UK and Middle East



Sunday, November 23, 2014 Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas in June 2014 confirmed as USA case NOT European

Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas

Updated: October 7, 2014

CDC and the Texas Department of State Health Services (DSHS) have completed the investigation of the recently reported fourth vCJD case in the United States. It confirmed that the case was in a US citizen born outside the Americas and indicated that the patient's exposure to the BSE/vCJD agent most likely occurred before he moved to the United States; the patient had resided in Kuwait, Russia and Lebanon. The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia. The specific overseas country where this patient’s infection occurred is less clear largely because the investigation did not definitely link him to a country where other known vCJD cases likely had been infected.

http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm

>>>the patient had resided in Kuwait, Russia and Lebanon.

>>>The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia.

NOW we all know why the state of Texas or the CDC did not want to report this case, because it was a home grown case of nvCJD right here in Texas?...tss

Monday, June 02, 2014

Confirmed Variant CJD Case in Texas

http://vcjd.blogspot.com/2014/06/confirmed-variant-cjd-case-in-texas.html Saturday, July 18, 2015

SPONTANEOUS TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY TSE PRION AKA MAD COW TYPE DISEASE, DOES IT EXIST NATURALLY IN THE FIELD?

http://transmissiblespongiformencephalop...spongiform.html

Re: CWD in Texas [Re: therancher] #5837684 07/18/15 10:57 PM
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Originally Posted By: therancher
You really shouldn't attach your blather to official links. It's bad form IMO.

Really? "Texas fell to mad cow disease"??

I guess I slept thru that.



I guess you did sleep through the Texas mad cow case that was finally confirmed after the great state of Texas tried covering it up. took 7 months and an act of congress to get that mad cow case finally confirmed. see for yourself ;


1st mad cow that got away $$$

FOR IMMEDIATE RELEASE Statement May 4, 2004 Media Inquiries: 301-827-6242 Consumer Inquiries: 888-INFO-FDA

Statement on Texas Cow With Central Nervous System Symptoms

On Friday, April 30 th , the Food and Drug Administration learned that a cow with central nervous system symptoms had been killed and shipped to a processor for rendering into animal protein for use in animal feed.

FDA, which is responsible for the safety of animal feed, immediately began an investigation. On Friday and throughout the weekend, FDA investigators inspected the slaughterhouse, the rendering facility, the farm where the animal came from, and the processor that initially received the cow from the slaughterhouse.

FDA's investigation showed that the animal in question had already been rendered into "meat and bone meal" (a type of protein animal feed). Over the weekend FDA was able to track down all the implicated material. That material is being held by the firm, which is cooperating fully with FDA.

http://www.fda.gov/bbs/topics/news/2004/NEW01061.html


ONE HUNDRED EIGHTH CONGRESS

COMMITTEE ON GOVERNMENT REFORM

May 13,2004

The Honorable Ann M. Veneman Secretary of Agriculture Department of Agriculture1400 Independence Avenue, SW Washington, DC 20250

Dear Madam Secretary:

I am writing to express concern that the recent failure of the U.S. Department of Agriculture (USDA) to test a Texas cow with neurological syrnptoms for bovine spongifonnencephalopathy (BSE) may reflect wider problems in the surveillance program. USDA apparently does not keep track of how many cows condemned for central nervous system symptoms are tested for BSE nor does it require that suspect carcasses be held pending testing...

FULL TEXT ;

http://oversight.house.gov/documents/20040607142914-86912.pdf


The 2nd mad cow that almost got away, brain samples laid up somewhere for 7 months, so the BSE MRR risk policy, so the BSE MRR risk policy, the legal trading of all strains of TSE prions was ratified. after an act of Congress and scientist from around the world complaining about it to the OIG, the sample was finally sent to Weybridge and CONFIRMED. ...


Release No. 0336.05 Contact: USDA Jim Rogers 202-690-4755 FDA Rae Jones 301-827- 6242

Printable version Email this page

U.S. Department of Agriculture (USDA) Food and Drug Administration (FDA)

Investigation Results of Texas Cow That Tested Positive for Bovine Spongiform Encephalopathy (BSE) Aug. 30, 2005

The U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) and the U.S. Department of Health and Human Services' Food and Drug Administration (FDA) have completed their investigations regarding a cow that tested positive for bovine spongiform encephalopathy (BSE) in June 2005. The agencies conducted these investigations in collaboration with the Texas Animal Health Commission and the Texas Feed and Fertilizer Control Service.

Our results indicate that the positive animal, called the index animal, was born and raised on a ranch (termed the "index farm") in Texas. It was a cream colored Brahma cross approximately 12 years old at the time of its death. It was born prior to the implementation of the 1997 feed ban instituted by FDA to help minimize the risk that a cow might consume feed contaminated with the agent thought to cause BSE. The animal was sold through a livestock sale in November of 2004 and transported to a packing plant. The animal was dead upon arrival at the packing plant and was then shipped to a pet food plant where it was sampled for BSE. The plant did not use the animal in its product, and the carcass was destroyed in November 2004.

APHIS attempted to trace all adult animals that left the index farm after 1990, as well as all progeny born within 2 years of the index animal's death. Together, these animals are called animals of interest.

During the course of the investigation, USDA removed and tested a total of 67 animals of interest from the farm where the index animal's herd originated. All of these animals tested negative for BSE. 200 adult animals of interest were determined to have left the index farm. Of these 200, APHIS officials determined that 143 had gone to slaughter, two were found alive (one was determined not to be of interest because of its age and the other tested negative), 34 are presumed dead, one is known dead and 20 have been classified as untraceable. In addition to the adult animals, APHIS was looking for two calves born to the index animal. Due to record keeping and identification issues, APHIS had to trace 213 calves. Of these 213 calves, 208 entered feeding and slaughter channels, four are presumed to have entered feeding and slaughter channels and one calf was untraceable.

To determine whether contaminated feed could have played a role in the index animal's infection, FDA and the Texas Feed and Fertilizer Control Service conducted a feed investigation with two main objectives: 1) to identify all protein sources in the animal=s feed history that could potentially have been the source of the BSE agent, and 2) to verify that cattle leaving the herd after 1997 were identified by USDA as animals of interest and were rendered in compliance with the 1997 BSE/ruminant feed rule.

The feed history investigation identified 21 feeds or feed supplements that were used on the farm since 1990. These feed ingredients were purchased from three retail feed stores and were manufactured at nine feed mills. This investigation found that no feed or feed supplements used on the farm since 1997 were formulated to contain prohibited mammalian protein. Due to this finding, FDA has concluded that the animal was most likely infected prior to the 1997 BSE/ruminant feed rule.

The investigation into the disposition of herd mates from this farm involved visits to nine slaughter plants and eight rendering plants. The investigation found that all of the rendering plants were operating in compliance with the BSE/ruminant feed rule. A review of the inspection history of each of these rendering firms found no violations of the FDA feed ban rule.

APHIS and FDA are very pleased with the results of their investigations, which show the animals of interest did not present a threat to livestock and that the ruminant feed rule is being followed. The U.S. maintains an interlocking system of safeguards designed to prevent BSE from entering the human and animal food chain. USDA also remains vigilant in its attempt to find BSE in the United States. To date, there have been more than 450,000 animals tested in the last 14 months and only two BSE positive animals found in this country.

For more information on USDA's epidemiological investigation and a copy of the report, please visit the APHIS website at http://www.aphis.usda.gov/lpa/issues/bse/bse.html or

http://www.aphis.usda.gov/lpa/issues/bse/epi-updates/bse_final_epidemiology_report.pdf

For more information on FDA's feed investigation, please visit the FDA's website at

http://www.fda.gov/cvm/texasfeedrpt.htm

Last Modified: 08/31/2005

http://www.usda.gov/wps/portal/usdahome?contentidonly=true&contentid=2005/08/0336.xml

Aug 30, 2005 USDA Texas BSE Investigation—Final Epidemiology Report

http://www.aphis.usda.gov/newsroom/hot_issues/bse/downloads/bse_final_epi_report8-05.pdf


TSS REPORT ON 2ND TEJAS MAD COW Mon, 22 Nov 2004 17:12:15 -0600 (the one that did NOT get away, thanks to the Honorable Phyllis Fong)


-------- Original Message --------

Subject: Re: BSE 'INCONCLUSIVE' COW from TEXAS ???

Date: Mon, 22 Nov 2004 17:12:15 –0600

From: "Terry S. Singeltary Sr." To: Carla Everett References: <[log in to unmask]> <[log in to unmask] us>

Greetings Carla,still hear a rumor;

Texas single beef cow not born in Canada no beef entered the food chain?

and i see the TEXAS department of animal health is ramping up forsomething, but they forgot a url for update?I HAVE NO ACTUAL CONFIRMATION YET...can you confirm???terry

==============================

-------- Original Message --------

Subject: Re: BSE 'INCONCLUSIVE' COW from TEXAS ???

Date: Fri, 19 Nov 2004 11:38:21 –0600

From: Carla Everett To: "Terry S. Singeltary Sr." References: <[log in to unmask]>

The USDA has made a statement, and we are referring all callers to the USDA web site. We have no information about the animal being in Texas. Carla

At 09:44 AM 11/19/2004, you wrote:

>Greetings Carla,

>>i am getting unsubstantiated claims of this BSE 'inconclusive' cow is from

>TEXAS. can you comment on this either way please?

>>thank you,

>Terry S. Singeltary Sr.

>>

===================

-------- Original Message --------

Subject: Re: BSE 'INCONCLUSIVE' COW from TEXAS ???

Date: Mon, 22 Nov 2004 18:33:20 -0600 From: Carla Everett

To: "Terry S. Singeltary Sr." References: <[log in to unmask]> <[log in to unmask] us> <[log in to unmask]> <[log in to unmask] us> <[log in to unmask]>

our computer department was working on a place holder we could postUSDA's announcement of any results. There are no results to be announced tonightby NVSL, so we are back in a waiting mode and will post the USDA announcement when we hear something.

At 06:05 PM 11/22/2004, you wrote:>why was the announcement on your TAHC site removed?

>>Bovine Spongiform Encephalopathy:

>November 22: Press Release title here

>>star image More BSE information

>>>>terry

>>Carla Everett wrote:

>>>no confirmation on the U.S.' inconclusive test...

>>no confirmation on location of animal.

>>>>>>

==========================

THEN, 7+ MONTHS OF COVER-UP BY JOHANN ET AL! no doubt about it now $$$

NO, it's not pretty, hell, im not pretty, but these are the facts, take em or leave em, however, you cannot change them.

with kindest regards,

I am still sincerely disgusted and tired in sunny Bacliff, Texas USA 77518

Terry S. Singeltary Sr.

FULL 130 LASHINGS TO USDA BY OIG again

http://www.usda.gov/oig/webdocs/50601-10-KC.pdf

Link: TSS

http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0612&L=sanet-mg&T=0&P=23557


News Release Texas Animal Health Commission Box l2966 * Austin, Texas 78711 * (800) 550-8242 * FAX (512) 719-0719 Bob Hillman, DVM * Executive Director For info, contact Carla Everett, information officer, at 1-800-550-8242, ext. 710, or ceverett@tahc.state.tx.us

For immediate release---

State-Federal Team Responds to Texas BSE Case

The US Department of Agriculture announced June 29 that genetic testing has verified that an aged cow that tested positive for Bovine Spongiform Encephalopathy or BSE originated from a Texas beef cattle herd. Tissues for laboratory testing were initially collected from the animal in November 2004, and the carcass was incinerated and did not enter the human food, animal feed or fertilizer supply system. While tests in November indicated the animal did not have BSE, retesting in England in June confirmed the animal had the disease. The Texas Animal Health Commission (TAHC), the state’s livestock and poultry health regulatory agency, and USDA have jointly assigned a state-federal team to conduct the epidemiological investigation and response.

“The TAHC and US Department of Agriculture’s Veterinary Services are working with a complement of experts from federal and state animal health, food safety, public health and feed regulatory agencies to ensure the continued safety and wholesomeness of our meat supply,” said Dr. Bob Hillman, Texas state veterinarian and executive director of the TAHC, the state’s livestock and poultry health regulatory agency. “Epidemiological investigations are thorough and focus on verifying the herd of origin, and when, where and how the animal and potentially, any herd mates, were exposed to the abnormal prion, or disease agent, that causes BSE. Additionally, epidemiology investigations trace the infected animal’s movement and herd mates. Animals potentially exposed to the disease will be depopulated, with proper disposal. The animals will not be introduced into the human or animal food chain.”

The USDA’s BSE testing protocol requires testing of emaciated or injured cattle, cattle that exhibit central nervous system disorder, cattle unable to rise or to walk normally, and cattle that die of unknown causes. Since June 1, 2004, brain tissue samples from more than 394,000 cattle have been tested in the U.S. and were negative for BSE. Of those, 38,320 were tested in Texas, Dr. Hillman noted. BSE surveillance has been conducted in the U.S. since l990.

The U.S. has taken preventive measures against the introduction of BSE since l989, when prohibitions were placed on cattle and other ruminants from BSE-affected countries, noted Dr. Hillman. In 1997, the importation ban was extended to all of Europe.

Dr. Hillman said the U.S. Food and Drug Administration (FDA) in 1997 banned the use of ruminant-derived protein (from animals such as cattle and sheep) in feed for cattle and other ruminants. There is no evidence that BSE spreads from live animal to animal in the herd, but cattle can be exposed by eating feed that contains rendered protein from infected animals. “These measures taken by the USDA and the FDA are safeguards that work to protect livestock, and ultimately, our meat supply,” he said.

--30--

http://www.tahc.state.tx.us/news/pr/2005/2005Jun30_BSE_Positive_Results.pdf

THE USDA JUNE 2004 ENHANCED BSE SURVEILLANCE PROGRAM WAS TERRIBLY FLAWED ;

CDC DR. PAUL BROWN TSE EXPERT COMMENTS 2006

In an article today for United Press International, science reporter Steve Mitchell writes:

Analysis: What that mad cow means

By STEVE MITCHELL UPI Senior Medical Correspondent

WASHINGTON, March 15 (UPI) -- The U.S. Department of Agriculture was quick to assure the public earlier this week that the third case of mad cow disease did not pose a risk to them, but what federal officials have not acknowledged is that this latest case indicates the deadly disease has been circulating in U.S. herds for at least a decade.

The second case, which was detected last year in a Texas cow and which USDA officials were reluctant to verify, was approximately 12 years old.

These two cases (the latest was detected in an Alabama cow) present a picture of the disease having been here for 10 years or so, since it is thought that cows usually contract the disease from contaminated feed they consume as calves. The concern is that humans can contract a fatal, incurable, brain-wasting illness from consuming beef products contaminated with the mad cow pathogen.

"The fact the Texas cow showed up fairly clearly implied the existence of other undetected cases," Dr. Paul Brown, former medical director of the National Institutes of Health's Laboratory for Central Nervous System Studies and an expert on mad cow-like diseases, told United Press International. "The question was, 'How many?' and we still can't answer that."

Brown, who is preparing a scientific paper based on the latest two mad cow cases to estimate the maximum number of infected cows that occurred in the United States, said he has "absolutely no confidence in USDA tests before one year ago" because of the agency's reluctance to retest the Texas cow that initially tested positive.

USDA officials finally retested the cow and confirmed it was infected seven months later, but only at the insistence of the agency's inspector general.

"Everything they did on the Texas cow makes everything they did before 2005 suspect," Brown said.

Despite this, Brown said the U.S. prevalence of mad cow, formally known as bovine spongiform encephalopathy, or BSE, did not significantly threaten human or cattle health.

"Overall, my view is BSE is highly unlikely to pose any important risk either in cattle feed or human feed," he said.

However, Jean Halloran of Consumers Union in Yonkers, N.Y., said consumers should be troubled by the USDA's secrecy and its apparent plan to dramatically cut back the number of mad cow tests it conducts.

"Consumers should be very concerned about how little we know about the USDA's surveillance program and the failure of the USDA to reveal really important details," Halloran told UPI. "Consumers have to be really concerned if they're going to cut back the program," she added.

Last year the USDA tested more than 300,000 animals for the disease, but it has proposed, even in light of a third case, scaling back the program to 40,000 tests annually.

"They seem to be, in terms of actions and policies, taking a lot more seriously the concerns of the cattle industry than the concerns of consumers," Halloran said. "It's really hard to know what it takes to get this administration to take action to protect the public."

The USDA has insisted that the safeguards of a ban on incorporating cow tissue into cattle feed (which is thought to spread the disease) and removal of the most infectious parts of cows, such as the brain and spinal cord, protect consumers. But the agency glosses over the fact that both of these systems have been revealed to be inadequately implemented.

The feed ban, which is enforced by the Food and Drug Administration, has been criticized by the Government Accountability Office in two reports, the most recent coming just last year. The GAO said the FDA's enforcement of the ban continues to have weaknesses that "undermine the nation's firewall against BSE."

USDA documents released last year showed more than 1,000 violations of the regulations requiring the removal of brains and spinal cords in at least 35 states, Puerto Rico and the Virgin Islands, with some plants being cited repeatedly for infractions. In addition, a violation of similar regulations that apply to beef exported to Japan is the reason why Japan closed its borders to U.S. beef in January six weeks after reopening them.

Other experts also question the adequacy of the USDA's surveillance system. The USDA insists the prevalence of mad cow disease is low, but the agency has provided few details of its surveillance program, making it difficult for outside experts to know if the agency's monitoring plan is sufficient.

"It's impossible to judge the adequacy of the surveillance system without having a breakdown of the tested population by age and risk status," Elizabeth Mumford, a veterinarian and BSE expert at Safe Food Solutions in Bern, Switzerland, a company that provides advice on reducing mad cow risk to industry and governments, told UPI.

"Everybody would be happier and more confident and in a sense it might be able to go away a little bit for (the USDA) if they would just publish a breakdown on the tests," Mumford added.

UPI requested detailed records about animals tested under the USDA's surveillance plan via the Freedom of Information Act in May 2004 but nearly two years later has not received any corresponding documents from the agency, despite a federal law requiring agencies to comply within 30 days. This leaves open the question of whether the USDA is withholding the information, does not have the information or is so haphazardly organized that it cannot locate it.

Mumford said the prevalence of the disease in U.S. herds is probably quite low, but there have probably been other cases that have so far gone undetected. "They're only finding a very small fraction of that low prevalence," she said.

Mumford expressed surprise at the lack of concern about the deadly disease from American consumers. "I would expect the U.S. public to be more concerned," she said.

Markus Moser, a molecular biologist and chief executive officer of Prionics, a Swiss firm that manufactures BSE test kits, told UPI one concern is that if people are infected, the mad cow pathogen could become "humanized" or more easily transmitted from person to person.

"Transmission would be much easier, through all kinds of medical procedures" and even through the blood supply, Moser said.

© Copyright 2006 United Press International, Inc. All Rights Reserved

http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060315-055557-1284r

http://www.upi.com/Science_News/2003/12/...47861072816318/

CDC - Bovine Spongiform Encephalopathy and Variant Creutzfeldt ... Dr. Paul Brown is Senior Research Scientist in the Laboratory of Central Nervous System ... Address for correspondence: Paul Brown, Building 36, Room 4A-05, ...

http://www.cdc.gov/ncidod/eid/vol7no1/brown.htm

PAUL BROWN COMMENT TO ME ON THIS ISSUE

Tuesday, September 12, 2006 11:10 AM

"Actually, Terry, I have been critical of the USDA handling of the mad cow issue for some years, and with Linda Detwiler and others sent lengthy detailed critiques and recommendations to both the USDA and the Canadian Food Agency." ........TSS

http://madcowtesting.blogspot.com/2009/07/mad-cow-cover-up-usa-masked-as-sporadic.html

OR, what the Honorable Phyllis Fong of the OIG found ;

Audit Report Animal and Plant Health Inspection Service Bovine Spongiform Encephalopathy (BSE) Surveillance Program ­ Phase II and Food Safety and Inspection Service

Controls Over BSE Sampling, Specified Risk Materials, and Advanced Meat Recovery Products - Phase III

Report No. 50601-10-KC January 2006

Finding 2 Inherent Challenges in Identifying and Testing High-Risk Cattle Still Remain

http://www.usda.gov/oig/webdocs/50601-10-KC.pdf

Subject: USDA OIG SEMIANNUAL REPORT TO CONGRESS FY 2007 1st Half (bogus BSE sampling FROM HEALTHY USDA CATTLE)

Date: June 21, 2007 at 2:49 pm PST

Owner and Corporation Plead Guilty to Defrauding Bovine Spongiform Encephalopathy (BSE) Surveillance Program

An Arizona meat processing company and its owner pled guilty in February 2007 to charges of theft of Government funds, mail fraud, and wire fraud. The owner and his company defrauded the BSE Surveillance Program when they falsified BSE Surveillance Data Collection Forms and then submitted payment requests to USDA for the services. In addition to the targeted sample population (those cattle that were more than 30 months old or had other risk factors for BSE), the owner submitted to USDA, or caused to be submitted, BSE obex (brain stem) samples from healthy USDA-inspected cattle. As a result, the owner fraudulently received approximately $390,000. Sentencing is scheduled for May 2007.

snip...

Topics that will be covered in ongoing or planned reviews under Goal 1 include:

soundness of BSE maintenance sampling (APHIS),

implementation of Performance-Based Inspection System enhancements for specified risk material (SRM) violations and improved inspection controls over SRMs (FSIS and APHIS),

snip...

The findings and recommendations from these efforts will be covered in future semiannual reports as the relevant audits and investigations are completed.

4 USDA OIG SEMIANNUAL REPORT TO CONGRESS FY 2007 1st Half

http://www.usda.gov/oig/webdocs/sarc070619.pdf

THIS is just ONE month report, of TWO recalls of prohibited banned MBM, which is illegal, mixed with 85% blood meal, which is still legal, but yet we know the TSE/BSE agent will transmit blood. we have this l-BSE in North America that is much more virulent and there is much concern with blood issue and l-BSE as there is with nvCJD in humans. some are even starting to be concerned with sporadic CJD and blood, and there are studies showing transmission there as well. ... this is one month recall page, where 10 MILLION POUNDS OF BANNED MAD COW FEED WENT OUT INTO COMMERCE, TO BE FED OUT. very little of the product that reaches commerce is ever returned via recall, very, very little. this was 2007, TEN YEARS AFTER THE AUGUST 4, 1997, PARTIAL AND VOLUNTARY MAD COW FEED BAN IN THE USA, that was nothing but ink on paper. i have listed the tonnage of mad cow feed that was in ALABAMA in one of the links too, this is where the infamous g-h-BSEalabama case was, a genetic relation matching the new sporadic CJD in the USA. seems this saga just keeps getting better and better.......$$$

10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN COMMERCE USA 2007

snip...see full text ;

Tuesday, November 02, 2010

IN CONFIDENCE

The information contained herein should not be disseminated further except on the basis of "NEED TO KNOW".

BSE - ATYPICAL LESION DISTRIBUTION (RBSE 92-21367) statutory (obex only) diagnostic criteria CVL 1992

http://bse-atypical.blogspot.com/2010/11/bse-atypical-lesion-distribution-rbse.html

2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006

http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html


I'm just saying...

Re: CWD in Texas [Re: Frio County Hunts] #5837692 07/18/15 11:03 PM
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whew!.. I need a burger after that long reply! grin

Re: CWD in Texas [Re: Frio County Hunts] #5837895 07/19/15 02:18 AM
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Flounder, no one here believes Texas fell to mad cow. Stop posting non sense links. Take off your tin foil hat and relax.

That being said, ranch in medina tried getting the tpwd to sign an agreement on the amount of deer they would kill. Tpwd declined, shocking, so basically the situation is right where it started.

Re: CWD in Texas [Re: flounder] #5838022 07/19/15 04:43 AM
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Flounder, you do realize that more people die of drowning in 5 gallon buckets in Texas each year than die of CJD right?

So, I guess "Texas 'fell' to 5 gallon buckets" too?

Quitit!


Crotchety old bastidge
Re: CWD in Texas [Re: flounder] #5838058 07/19/15 06:18 AM
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Originally Posted By: flounder



CDC and the Texas Department of State Health Services (DSHS) have completed the investigation of the recently reported fourth vCJD case in the United States. It confirmed that the case was in a US citizen born outside the Americas and indicated that the patient's exposure to the BSE/vCJD agent most likely occurred before he moved to the United States; the patient had resided in Kuwait, Russia and Lebanon. The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia. The specific overseas country where this patient’s infection occurred is less clear largely because the investigation did not definitely link him to a country where other known vCJD cases likely had been infected.


Bold, italics, and underline mine.

Did you even read what you posted? Read the part that I bolded, underlined and put in italics.

You might want to take a lesson or two on how to effectively post instead of cutting and pasting pages of stuff that nobody will read. If a post is not succinct no one will read it regardless of what is posted. In fact it appears you do not even read your own posts as the section I highlighted nullifies your point.

Last edited by Hirogen; 07/19/15 06:22 AM.

Never violate a woman, nor harm a child. Do not lie, cheat or steal. These things are for lesser men. Protect the weak against the evil strong. And never allow thoughts of gain to lead you into the pursuit of evil.

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Re: CWD in Texas [Re: therancher] #5838299 07/19/15 04:01 PM
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Originally Posted By: therancher
Flounder, you do realize that more people die of drowning in 5 gallon buckets in Texas each year than die of CJD right?

So, I guess "Texas 'fell' to 5 gallon buckets" too?

Quitit!



someone posted ;



>>>A UK immigrant died of vCJD earlier this year. He relocated to TX but still traveled a lot to the UK and Middle East <<<



I just corrected what was posted about this cases being from the UK or Saudi, it wasn't, and officials have not a clue where it was sourced, this nvCJD very well could be sourced from the USA. just saying...


>>>The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia. <<<

http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm



>>>The specific overseas country where this patient’s infection occurred is less clear largely because the investigation did not definitely link him to a country where other known vCJD cases likely had been infected. <<<



http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm



kind regards, terry

Re: CWD in Texas [Re: flounder] #5838301 07/19/15 04:05 PM
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Originally Posted By: flounder
Originally Posted By: therancher
Flounder, you do realize that more people die of drowning in 5 gallon buckets in Texas each year than die of CJD right?

So, I guess "Texas 'fell' to 5 gallon buckets" too?

Quitit!



someone posted ;



>>>A UK immigrant died of vCJD earlier this year. He relocated to TX but still traveled a lot to the UK and Middle East <<<



I just corrected what was posted about this cases being from the UK or Saudi, it wasn't, and officials have not a clue where it was sourced, this nvCJD very well could be sourced from the USA. just saying...


>>>The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia. <<<

http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm



>>>The specific overseas country where this patient’s infection occurred is less clear largely because the investigation did not definitely link him to a country where other known vCJD cases likely had been infected. <<<



http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm



kind regards, terry




Yeah, not sure why you replied to my post. Since it has nothing to do with your reply.


Crotchety old bastidge
Re: CWD in Texas [Re: flounder] #5838307 07/19/15 04:08 PM
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Originally Posted By: flounder
Originally Posted By: therancher
Flounder, you do realize that more people die of drowning in 5 gallon buckets in Texas each year than die of CJD right?

So, I guess "Texas 'fell' to 5 gallon buckets" too?

Quitit!



someone posted ;



>>>A UK immigrant died of vCJD earlier this year. He relocated to TX but still traveled a lot to the UK and Middle East <<<



I just corrected what was posted about this cases being from the UK or Saudi, it wasn't, and officials have not a clue where it was sourced, this nvCJD very well could be sourced from the USA. just saying...


>>>The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia. <<<

http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm



>>>The specific overseas country where this patient’s infection occurred is less clear largely because the investigation did not definitely link him to a country where other known vCJD cases likely had been infected. <<<



http://www.cdc.gov/ncidod/dvrd/vcjd/other/confirmed-case-in-texas.htm



kind regards, terry




Middle East sources beef all over with big part being from the EU. Especially kiwuit

Only way for US beef to have mad cow Is if it is imported from Canada!!!

There for at this time it's impossible of US sourced beef to have mad cow.....Unless mad cow is a genetic mutation

Re: CWD in Texas [Re: Hirogen] #5838308 07/19/15 04:11 PM
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Originally Posted By: Hirogen
Originally Posted By: flounder



CDC and the Texas Department of State Health Services (DSHS) have completed the investigation of the recently reported fourth vCJD case in the United States. It confirmed that the case was in a US citizen born outside the Americas and indicated that the patient's exposure to the BSE/vCJD agent most likely occurred before he moved to the United States; the patient had resided in Kuwait, Russia and Lebanon. The completed investigation did not support the patient's having had extended travel to European countries, including the United Kingdom, or travel to Saudi Arabia. The specific overseas country where this patient’s infection occurred is less clear largely because the investigation did not definitely link him to a country where other known vCJD cases likely had been infected.


Bold, italics, and underline mine.

Did you even read what you posted? Read the part that I bolded, underlined and put in italics.

You might want to take a lesson or two on how to effectively post instead of cutting and pasting pages of stuff that nobody will read. If a post is not succinct no one will read it regardless of what is posted. In fact it appears you do not even read your own posts as the section I highlighted nullifies your point.


I see I was late. But I was going to tell you that flounder posts the stuff in bold above to point out the "lies".

Of course, it should be obvious to you and i that Texas has been decimated by cjd (and CWD). People are dying all around us from it!

It's the cause of all cancers and heart attacks and strokes! Why, I'll bet flounder has documented proof that it causes the majority of fatal auto accidents!

Dear God in Texas heaven we're all doomed!!!!


Crotchety old bastidge
Re: CWD in Texas [Re: Frio County Hunts] #5838358 07/19/15 04:53 PM
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Evidence That Transmissible Mink Encephalopathy Results from Feeding Infected Cattle


Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME.

snip...

The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...



http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/mb/m09/tab05.pdf


http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/mb/m09a/tab01.pdf


http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/yb/1987/06/10004001.pdf



kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5838365 07/19/15 05:00 PM
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In Confidence - Perceptions of unconventional slow virus diseases of animals in the USA - APRIL-MAY 1989 - G A H Wells

3. Prof. A. Robertson gave a brief account of BSE. The US approach was to accord it a very low profile indeed. Dr. A Thiermann showed the picture in the ''Independent'' with cattle being incinerated and thought this was a fanatical incident to be avoided in the US at all costs. ...

http://web.archive.org/web/20060307063531/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf


kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5838368 07/19/15 05:06 PM
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BSE was a special case that went through virulence amplification by being contantly cycled through the feed system. The use of rendered mammals, for mammal feeds, has been illegal for a long time, so there is no relevance of TME from BSE infected cattle, to this discussion.


for every stereotype there's a prototype don't be the prototype
Re: CWD in Texas [Re: Frio County Hunts] #5838375 07/19/15 05:15 PM
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And 18 plus years later....US still bans protein made from cows, sheep, deer, and other so-called ruminants in feed for other ruminants.


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: nsmike] #5838378 07/19/15 05:17 PM
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Originally Posted By: nsmike
BSE was a special case that went through virulence amplification by being contantly cycled through the feed system. The use of rendered mammals, for mammal feeds, has been illegal for a long time, so there is no relevance of TME from BSE infected cattle, to this discussion.



we are still feeding animal protein to cattle and deer, and it's still perfectly legal to feed it to cervids. as late as one decade post mad cow feed ban of August 1997, in 2007 some 10,000,000 pounds of banned blood laced meat and bone meal went out into public. with the year 2013 and 2014 mad cow feed ban still failing terribly. the oral route of cwd to deer is very real, and feed is a likely source as well...just saying.


Date: March 21, 2007 at 2:27 pm PST

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm


Terry S. Singeltary Sr.

*** See attached file(s) No documents available. Attachments View All (1) Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed On-Farm Terry Singeltary Comment View Attachment:

http://www.regulations.gov/#!documentDetail;D=FDA-2014-D-1180-0003


Sunday, April 5, 2015

*** Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed On-Farm Draft Guidance FDA-2014-D-1180 ***

http://madcowfeed.blogspot.com/2015/04/guidance-for-industry-ensuring-safety.html


Comment from Terry Singeltary Sr.

This is a Comment on the Animal and Plant Health Inspection Service (APHIS) Notice: Agency Information Collection Activities; Proposals, Submissions, and Approvals: Bovine Spongiform Encephalopathy; Importation of Animals and Animal Products


For related information, Open Docket Folder Docket folder icon snip...end


31 Jan 2015 at 20:14 GMT

*** Ruminant feed ban for cervids in the United States? ***

31 Jan 2015 at 20:14 GMT

http://www.plosone.org/annotation/listThread.action?root=85351


Tuesday, December 23, 2014

FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2014 BSE TSE PRION

http://madcowusda.blogspot.com/2014/12/fda-part-589-substances-prohibited-from.html


2013

Sunday, December 15, 2013

FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE

http://madcowusda.blogspot.com/2013/12/fda-part-589-substances-prohibited-from.html


DOCKET-- 03D-0186 -- FDA Issues Draft Guidance on Use of Material From Deer and Elk in Animal Feed; Availability Date: Fri, 16 May 2003 11:47:37 0500 EMC 1 Terry S. Singeltary Sr. Vol #: 1

http://www.fda.gov/ohrms/dockets/dailys/03/Jun03/060903/060903.htm

http://www.fda.gov/ohrms/dockets/dailys/03/oct03/100203/100203.htm


PLEASE SEE FULL TEXT SUBMISSION ;

http://madcowfeed.blogspot.com/2008/07/docket-03d-0186-fda-issues-draft.html


Sunday, July 12, 2015

Insights into CWD and BSE species barriers using real-time conversion

http://transmissiblespongiformencephalop...se-species.html

*** Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.

http://transmissiblespongiformencephalop...tential-of.html



kind regards, terry

Re: CWD in Texas [Re: flounder] #5838387 07/19/15 05:24 PM
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Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus )

Christina J. Sigurdson1, Elizabeth S. Williams2, Michael W. Miller3, Terry R. Spraker1,4, Katherine I. O'Rourke5 and Edward A. Hoover1

Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523- 1671, USA1 Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, University of Wyoming, Laramie, WY 82070, USA 2 Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526-2097, USA3 Colorado State University Veterinary Diagnostic Laboratory, 300 West Drake Road, Fort Collins, CO 80523-1671, USA4 Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, 337 Bustad Hall, Washington State University, Pullman, WA 99164-7030, USA5

Author for correspondence: Edward Hoover.Fax +1 970 491 0523. e-mail ehoover@lamar.colostate.edu

Mule deer fawns (Odocoileus hemionus) were inoculated orally with a brain homogenate prepared from mule deer with naturally occurring chronic wasting disease (CWD), a prion-induced transmissible spongiform encephalopathy. Fawns were necropsied and examined for PrP res, the abnormal prion protein isoform, at 10, 42, 53, 77, 78 and 80 days post-inoculation (p.i.) using an immunohistochemistry assay modified to enhance sensitivity. PrPres was detected in alimentary-tract-associated lymphoid tissues (one or more of the following: retropharyngeal lymph node, tonsil, Peyer's patch and ileocaecal lymph node) as early as 42 days p.i. and in all fawns examined thereafter (53 to 80 days p.i.). No PrPres staining was detected in lymphoid tissue of three control fawns receiving a control brain inoculum, nor was PrPres detectable in neural tissue of any fawn. PrPres-specific staining was markedly enhanced by sequential tissue treatment with formic acid, proteinase K and hydrated autoclaving prior to immunohistochemical staining with monoclonal antibody F89/160.1.5. These results indicate that CWD PrP res can be detected in lymphoid tissues draining the alimentary tract within a few weeks after oral exposure to infectious prions and may reflect the initial pathway of CWD infection in deer. The rapid infection of deer fawns following exposure by the most plausible natural route is consistent with the efficient horizontal transmission of CWD in nature and enables accelerated studies of transmission and pathogenesis in the native species.

snip...

These results indicate that mule deer fawns develop detectable PrP res after oral exposure to an inoculum containing CWD prions. In the earliest post-exposure period, CWD PrPres was traced to the lymphoid tissues draining the oral and intestinal mucosa (i.e. the retropharyngeal lymph nodes, tonsil, ileal Peyer's patches and ileocaecal lymph nodes), which probably received the highest initial exposure to the inoculum. Hadlow et al. (1982) demonstrated scrapie agent in the tonsil, retropharyngeal and mesenteric lymph nodes, ileum and spleen in a 10-month-old naturally infected lamb by mouse bioassay. Eight of nine sheep had infectivity in the retropharyngeal lymph node. He concluded that the tissue distribution suggested primary infection via the gastrointestinal tract. The tissue distribution of PrPres in the early stages of infection in the fawns is strikingly similar to that seen in naturally infected sheep with scrapie. These findings support oral exposure as a natural route of CWD infection in deer and support oral inoculation as a reasonable exposure route for experimental studies of CWD.

snip...

http://vir.sgmjournals.org/cgi/content/full/80/10/2757

Susceptibility of European Red Deer (Cervus elaphus elaphus) to Alimentary Challenge with Bovine Spongiform Encephalopathy

Abstract

European red deer (Cervus elaphus elaphus) are susceptible to the agent of bovine spongiform encephalopathy, one of the transmissible spongiform encephalopathies, when challenged intracerebrally but their susceptibility to alimentary challenge, the presumed natural route of transmission, is unknown. To determine this, eighteen deer were challenged via stomach tube with a large dose of the bovine spongiform encephalopathy agent and clinical signs, gross and histological lesions, presence and distribution of abnormal prion protein and the attack rate recorded. Only a single animal developed clinical disease, and this was acute with both neurological and respiratory signs, at 1726 days post challenge although there was significant (27.6%) weight loss in the preceding 141 days. The clinically affected animal had histological lesions of vacuolation in the neuronal perikaryon and neuropil, typical of transmissible spongiform encephalopathies. Abnormal prion protein, the diagnostic marker of transmissible encephalopathies, was primarily restricted to the central and peripheral nervous systems although a very small amount was present in tingible body macrophages in the lymphoid patches of the caecum and colon. Serial protein misfolding cyclical amplification, an in vitro ultra-sensitive diagnostic technique, was positive for neurological tissue from the single clinically diseased deer. All other alimentary challenged deer failed to develop clinical disease and were negative for all other investigations. These findings show that transmission of bovine spongiform encephalopathy to European red deer via the alimentary route is possible but the transmission rate is low. Additionally, when deer carcases are subjected to the same regulations that ruminants in Europe with respect to the removal of specified offal from the human food chain, the zoonotic risk of bovine spongiform encephalopathy, the cause of variant Creutzfeldt-Jakob disease, from consumption of venison is probably very low.

snip...

Discussion This investigation resulted in the first and only known case, to date, of clinical disease or accumulation of abnormal PrPd in any cervid species due to oral challenge with BSE. The increase in incubation period compared to European red deer challenged with BSE intra-cerebrally (1060 days) [33] compared to oral challenge (1727 days) is approximately 60% and similar to the differences observed in incubation periods for sheep or goats when challenged with TSE agents by these two routes [40,41]. The neurological clinical signs observed could be broadly related to the spongiform encephalopathy and the accumulation of PrPd in that the restlessness, stereotypic head movements and pacing may be due to compromise of the nucleus accumbens [42], found in the striatum, and the laboured breathing due to the lesions in the medulla, where the respiratory centre is located [43]. Alternatively, the laboured and audible mouth breathing may have been due to, or contributed to by, compromise of either of the recurrent laryngeal nerves resulting in some degree of laryngeal paralysis but we were unable to determine this. Apart from the gradual loss of body weight, the speed of onset of clinical signs and progression was very rapid but animal welfare requirements precluded any further longitudinal study of these. The clinical signs described for this animal are broadly similar to those reported for clinical BSE in European red deer challenged via the intracerebral route [33], clinical cases of CWD in deer [44] and clinical cases of BSE in cattle [45].

snip...see full text ;

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116094

I strenuously once again urge the FDA and its industry constituents, to make it MANDATORY that all ruminant feed be banned to all ruminants, and this should include all cervids as soon as possible for the following reasons...

======

In the USA, under the Food and Drug Administrations BSE Feed Regulation (21 CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from deer and elk is prohibited for use in feed for ruminant animals. With regards to feed for non-ruminant animals, under FDA law, CWD positive deer may not be used for any animal feed or feed ingredients. For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system.

***However, this recommendation is guidance and not a requirement by law.

======

31 Jan 2015 at 20:14 GMT

*** Ruminant feed ban for cervids in the United States? ***

31 Jan 2015 at 20:14 GMT

http://www.plosone.org/annotation/listThread.action?root=85351

Friday, December 14, 2012

DEFRA U.K. What is the risk of Chronic Wasting Disease CWD being introduced into Great Britain? A Qualitative Risk Assessment October 2012

snip...

In the USA, under the Food and Drug Administration’s BSE Feed Regulation (21 CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from deer and elk is prohibited for use in feed for ruminant animals. With regards to feed for non-ruminant animals, under FDA law, CWD positive deer may not be used for any animal feed or feed ingredients. For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law.

Animals considered at high risk for CWD include:

1) animals from areas declared to be endemic for CWD and/or to be CWD eradication zones and

2) deer and elk that at some time during the 60-month period prior to slaughter were in a captive herd that contained a CWD-positive animal.

Therefore, in the USA, materials from cervids other than CWD positive animals may be used in animal feed and feed ingredients for non-ruminants.

The amount of animal PAP that is of deer and/or elk origin imported from the USA to GB can not be determined, however, as it is not specified in TRACES. It may constitute a small percentage of the 8412 kilos of non-fish origin processed animal proteins that were imported from US into GB in 2011.

Overall, therefore, it is considered there is a __greater than negligible risk___ that (nonruminant) animal feed and pet food containing deer and/or elk protein is imported into GB.

There is uncertainty associated with this estimate given the lack of data on the amount of deer and/or elk protein possibly being imported in these products.

snip...

36% in 2007 (Almberg et al., 2011). In such areas, population declines of deer of up to 30 to 50% have been observed (Almberg et al., 2011). In areas of Colorado, the prevalence can be as high as 30% (EFSA, 2011). The clinical signs of CWD in affected adults are weight loss and behavioural changes that can span weeks or months (Williams, 2005). In addition, signs might include excessive salivation, behavioural alterations including a fixed stare and changes in interaction with other animals in the herd, and an altered stance (Williams, 2005). These signs are indistinguishable from cervids experimentally infected with bovine spongiform encephalopathy (BSE). Given this, if CWD was to be introduced into countries with BSE such as GB, for example, infected deer populations would need to be tested to differentiate if they were infected with CWD or BSE to minimise the risk of BSE entering the human food-chain via affected venison.

snip...

The rate of transmission of CWD has been reported to be as high as 30% and can approach 100% among captive animals in endemic areas (Safar et al., 2008).

snip...

In summary, in endemic areas, there is a medium probability that the soil and surrounding environment is contaminated with CWD prions and in a bioavailable form. In rural areas where CWD has not been reported and deer are present, there is a greater than negligible risk the soil is contaminated with CWD prion.

snip...

In summary, given the volume of tourists, hunters and servicemen moving between GB and North America, the probability of at least one person travelling to/from a CWD affected area and, in doing so, contaminating their clothing, footwear and/or equipment prior to arriving in GB is greater than negligible. For deer hunters, specifically, the risk is likely to be greater given the increased contact with deer and their environment. However, there is significant uncertainty associated with these estimates.

snip...

Therefore, it is considered that farmed and park deer may have a higher probability of exposure to CWD transferred to the environment than wild deer given the restricted habitat range and higher frequency of contact with tourists and returning GB residents.

snip...

http://webarchive.nationalarchives.gov.uk/20130822084033/http://www.defra.gov.uk/animal-diseases/files/qra_chronic-wasting-disease-121029.pdf



kind regards, terry



Originally Posted By: flounder
Originally Posted By: nsmike
BSE was a special case that went through virulence amplification by being contantly cycled through the feed system. The use of rendered mammals, for mammal feeds, has been illegal for a long time, so there is no relevance of TME from BSE infected cattle, to this discussion.



we are still feeding animal protein to cattle and deer, and it's still perfectly legal to feed it to cervids. as late as one decade post mad cow feed ban of August 1997, in 2007 some 10,000,000 pounds of banned blood laced meat and bone meal went out into public. with the year 2013 and 2014 mad cow feed ban still failing terribly. the oral route of cwd to deer is very real, and feed is a likely source as well...just saying.


Date: March 21, 2007 at 2:27 pm PST

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm


Terry S. Singeltary Sr.

*** See attached file(s) No documents available. Attachments View All (1) Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed On-Farm Terry Singeltary Comment View Attachment:

http://www.regulations.gov/#!documentDetail;D=FDA-2014-D-1180-0003


Sunday, April 5, 2015

*** Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed On-Farm Draft Guidance FDA-2014-D-1180 ***

http://madcowfeed.blogspot.com/2015/04/guidance-for-industry-ensuring-safety.html


Comment from Terry Singeltary Sr.

This is a Comment on the Animal and Plant Health Inspection Service (APHIS) Notice: Agency Information Collection Activities; Proposals, Submissions, and Approvals: Bovine Spongiform Encephalopathy; Importation of Animals and Animal Products


For related information, Open Docket Folder Docket folder icon snip...end


31 Jan 2015 at 20:14 GMT

*** Ruminant feed ban for cervids in the United States? ***

31 Jan 2015 at 20:14 GMT

http://www.plosone.org/annotation/listThread.action?root=85351


Tuesday, December 23, 2014

FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2014 BSE TSE PRION

http://madcowusda.blogspot.com/2014/12/fda-part-589-substances-prohibited-from.html


2013

Sunday, December 15, 2013

FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE

http://madcowusda.blogspot.com/2013/12/fda-part-589-substances-prohibited-from.html


DOCKET-- 03D-0186 -- FDA Issues Draft Guidance on Use of Material From Deer and Elk in Animal Feed; Availability Date: Fri, 16 May 2003 11:47:37 0500 EMC 1 Terry S. Singeltary Sr. Vol #: 1

http://www.fda.gov/ohrms/dockets/dailys/03/Jun03/060903/060903.htm

http://www.fda.gov/ohrms/dockets/dailys/03/oct03/100203/100203.htm


PLEASE SEE FULL TEXT SUBMISSION ;

http://madcowfeed.blogspot.com/2008/07/docket-03d-0186-fda-issues-draft.html


Sunday, July 12, 2015

Insights into CWD and BSE species barriers using real-time conversion

http://transmissiblespongiformencephalop...se-species.html

*** Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.

http://transmissiblespongiformencephalop...tential-of.html



kind regards, terry

Re: CWD in Texas [Re: Frio County Hunts] #5838687 07/19/15 09:58 PM
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PLEASE troll ANYMORE


Lucky 7 Exotic Ranch located in Eden, Tx. Well managed self sustaining herds roaming our 3,000 acre ranch. First Class Lodging, Ranch style meals and qualified guides. 30+ species.
Re: CWD in Texas [Re: Frio County Hunts] #5838933 07/20/15 01:37 AM
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With all the links that flounder has posted...how in the heck are we as humans still alive today and can wildlife numbers continue to grow at the rates they do? confused2 I will bolt since the sky is falling.


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Re: CWD in Texas [Re: Frio County Hunts] #5850673 07/27/15 09:43 PM
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Update on the CWD situation. TPWD discovered that the farm in Medina had sold some deer to a ranch in Mexico awhile back. So, because of that, this has become a Federal issue. The Feds had a meeting with the owners and basically told them what the deal was. All the deer on the Medina ranch are being killed. I heard through the grapevine that so far, over half of the deer have been killed and tested for CWD. And so far, not one has tested positive for CWD. It will be really interesting to hear the explanation if there are no more positive tests that come off that ranch.

Re: CWD in Texas [Re: jmh004] #5850697 07/27/15 09:57 PM
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Originally Posted By: jmh004
Update on the CWD situation. TPWD discovered that the farm in Medina had sold some deer to a ranch in Mexico awhile back. So, because of that, this has become a Federal issue. The Feds had a meeting with the owners and basically told them what the deal was. All the deer on the Medina ranch are being killed. I heard through the grapevine that so far, over half of the deer have been killed and tested for CWD. And so far, not one has tested positive for CWD. It will be really interesting to hear the explanation if there are no more positive tests that come off that ranch.


No they will just say it didn't make it through its incubation period.... You control via fear, not facts or science

Such a waste of resources and an A+ testing facility


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5850712 07/27/15 10:05 PM
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I have heard over the weekend that well over 50 over the deer sold to other breeders have been slaughtered by the breeder pen owners who got them and all were taken in for testing. None of them have tested positive for CWD.


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Re: CWD in Texas [Re: jmh004] #5850721 07/27/15 10:09 PM
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Originally Posted By: jmh004
Update on the CWD situation. TPWD discovered that the farm in Medina had sold some deer to a ranch in Mexico awhile back. So, because of that, this has become a Federal issue. The Feds had a meeting with the owners and basically told them what the deal was. All the deer on the Medina ranch are being killed. I heard through the grapevine that so far, over half of the deer have been killed and tested for CWD. And so far, not one has tested positive for CWD. It will be really interesting to hear the explanation if there are no more positive tests that come off that ranch.


If Feds are involved the rest of those deer are as good as gone. They cast a really wide net.

Re: CWD in Texas [Re: jmh004] #5851209 07/28/15 02:46 AM
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Originally Posted By: jmh004
Update on the CWD situation. TPWD discovered that the farm in Medina had sold some deer to a ranch in Mexico awhile back. So, because of that, this has become a Federal issue. The Feds had a meeting with the owners and basically told them what the deal was. All the deer on the Medina ranch are being killed. I heard through the grapevine that so far, over half of the deer have been killed and tested for CWD. And so far, not one has tested positive for CWD. It will be really interesting to hear the explanation if there are no more positive tests that come off that ranch.

Interesting, I just heard that they have not killed any deer yet the Medina pens. They are going to start in the morning and kill over 35. 29 of those will be in the pen where the buck was that had CWD and then rest are related to that buck.


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Re: CWD in Texas [Re: Frio County Hunts] #5851509 07/28/15 01:05 PM
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According to my source, there's only about 50 deer left.

Re: CWD in Texas [Re: Frio County Hunts] #5851517 07/28/15 01:08 PM
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That is surprising to hear that Mexico would allow deer to be imported into the country.

And doesn't make alot of sense they would need to do that for a deer herd in Mexico.


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Re: CWD in Texas [Re: Pitchfork Predator] #5851558 07/28/15 01:35 PM
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Originally Posted By: Pitchfork Predator
That is surprising to hear that Mexico would allow deer to be imported into the country.

And doesn't make alot of sense they would need to do that for a deer herd in Mexico.



They sure don't have any issue with TB & tick fever cattle walking across to say hi to us....


Bottom line, never trust a man whose uncle was eaten by cannibals.-Sen Joni Ernst
Re: CWD in Texas [Re: Frio County Hunts] #5851567 07/28/15 01:40 PM
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......or their citizens. But try to bring things over there is usually expensive by the time you pay everybody off.


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Re: CWD in Texas [Re: Frio County Hunts] #5852300 07/28/15 09:14 PM
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state of Texas euthanized 35 deer Tuesday at a breeding facility in Medina County

http://www.mysanantonio.com/news/local/a...nch-6410354.php

I kindly submit the following for your files...

> The state of Texas euthanized 35 deer Tuesday at a breeding facility in Medina County so they can be tested for chronic wasting disease.

WHY ONLY 35 DEER? this is insane. if they don’t slaughter and test every one of those deer for CWD, including the fawns, especially from the index herd, then it’s business as usually in Texas. no telling how much CWD has been trucked from one captive facility to another inside of Texas, from who knows where. besides that, TAHC has known since 2001 that CWD was waltzing across Texas from New Mexico, because I told them it was, not that it mattered. CWD was discovered in 2012 right where I had told them it was in 2001-2002.

IF the state of Texas does not get serious real fast with CWD, and test all those deer, that 5 year plan is a ticking time bomb waiting to happen.

Here are two examples of what waiting can look like with CWD ;

http://chronic-wasting-disease.blogspot.com/2015/07/texas-kills-35-deer-at-medina-county.html

Re: CWD in Texas [Re: jmh004] #5852602 07/29/15 12:17 AM
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Originally Posted By: jmh004
According to my source, there's only about 50 deer left.

They just started today in Patterson's pens with 35 deer closely related to that buck or in the same pen as he was.


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Re: CWD in Texas [Re: Frio County Hunts] #5852730 07/29/15 02:04 AM
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So do they plan on killing the entire herd?

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