I have made an annual prairie dog trip since 2010.
Here's what I know.
-High volume, high speed shooting
-Barrels get hot, hot, hot!
-Shots from 5 yards to as far as you can spot them.
-Usually lots of mirage
-Not much to bounce a range finder laser off of
So, absolutely take the .223 and try to shoot it most. You have about 2500 rounds before your Creedmoor barrel is done, so keep that in mind when taking it on a prairie dog trip. I always leave mine at home for this very reason. If I take it, I will use it, and before I turn around I will have shot up a 50 round box of hand loads.
I take a .22-250 pushing 75 gr A-maxes @ 3200 fps. 500 rounds of that in two days is my normal.
But hey, if you feel like making some real long shots on the little critters the 6.5 Creedmoor is one of the best cartridges to do it with.
I have a video camera rig for this year. The camera mounts to the scope tube with pan and cant adjustment available. Hopefully it will work this year and I can film making prairie dogs cartwheel ten feet in the air.