I wouldn't hesitate to use a little lighter bullet though, especially in one of the monometals.
A Barnes x bullet 165 is about the same as a 180 lead bullet.
On a light weight 300 you need to shoot the lightest weight that will group well.
My point is to use the lightest bullet you can to keep from punishing your shoulder.
A Barnes x bullet 150 is about the same as a 150 lead bullet.
Think about it and borrow some 180gr and compare it to a 150 grain!!