Depends on what weight of bullet you use. The 155 hunting VLD has show massive amounts of fragmentation on deer from a 308 bolt gun. If you increase the weight and slow things down some, they will penetrate deeper and still get good fragmentation. I'll tell you this much. The nastiest wound channels I have ever seen have come from Berger VLD's pushed fast. I shot 2 does in about 2-3 seconds with my 260 Rem and 140 VLD. One was in the shoulder broad side, and I recovered some jacket material in the rear hams. Both had massive exit wounds, like grapefruit or cantaloupe size. Just don't go too light and you'll be good. Keep it 165 to 175 and you'll be good.