There is a 22caliber Suppressor that will handle the 22-250 that I believe was called VAPOR and if not mistaken made by SRT.
Most companies will just say use their 30 caliber though.
"Anyone taking up handloading necessarily plays with unknown factors and takes chances. But so does anyone who drives a car,goes to a cocktail party,eats in a restaurant,or gets married."
Jack O'Connor 1963