I've taken four moose over the years.
Shiras moose from Wyoming
Alaska-Yukon moose from the Hoholitna River area of Alaska
Eastern Canadian moose from Newfoundland
Western Canadian moose from British Columbia
They were shot with a .30-06, a .338WM, and a 7mmRM(2). They aren't particularly hard to kill or to hunt, but during the rut they'll come to you, which is pretty exciting. Moose meat is excellent fare, the best in North America, but unless you are able to drive your pickup to where you hunt, it's too expensive to fly it home. Every family in the north country lives on moose meat all through the winter.